ID   AREA_PENCH              Reviewed;         725 AA.
AC   Q01582;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Nitrogen regulatory protein areA;
DE            Short=Nitrogen regulator nre;
GN   Name=AREA; Synonyms=NRE;
OS   Penicillium chrysogenum (Penicillium notatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=5076;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7788718; DOI=10.1007/bf00313429;
RA   Haas H., Bauer B., Redl B., Stoeffler G., Marzluf G.A.;
RT   "Molecular cloning and analysis of nre, the major nitrogen regulatory gene
RT   of Penicillium chrysogenum.";
RL   Curr. Genet. 27:150-158(1995).
CC   -!- FUNCTION: Major nitrogen regulatory protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; U02612; AAA83400.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q01582; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00202; ZnF_GATA; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 1.
DR   Pfam; PF00320; GATA; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 1.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Metal-binding; Nitrate assimilation; Nucleus;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..725
FT                   /note="Nitrogen regulatory protein areA"
FT                   /id="PRO_0000083467"
FT   ZN_FING         525..549
FT                   /note="GATA-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          429..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          479..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          574..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..499
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..624
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        656..671
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   725 AA;  76848 MW;  45C24148F81F8D43 CRC64;
     MRLSDQVSPA GPDPSHDMNL DATSDPMNLD DFIVPFDSPA EHSAHPSVDR NFAATPTGSI
     PIKSRKDHAM TDSSTAASFP HPPQDQRTNS EFGYVPRRVR KTSVDERQFF AGLSVPTRKR
     PAEASPQVPP VSNAMMAHSS ELSAALPDYS LDHHLLLLLF LAMAQWAPPT SSPSHAFQHS
     LRLDTYGINE DHGLNSAGPY QQNFHFSPSD SPMTAGNPFS SLYAQTPLAS SLNSTEFFSP
     PPSGYQSTVS TPQPIYEGEQ SIFFSDAPSA ESHTQRRIPN YIQQRQSNLS ASLQPRYMYN
     MSNGESHPGS AVTGPPTTNM SGFSVPQHVN PSQVLGHGEF STTAPASSMF TFGGDSDNED
     DDGNFGERGG ITMPNDFASL DESVDMSAGL HWDGGFPGSV QSLPGFSAQT RKHVTIGSTD
     MIDGPLEWNQ GGTLGRAHGS AASVSEVRNQ NQDPRRYGKV PRTASTPNAA ALLRQSLNGS
     ASGLPTNHPS PSTLPESGLS SRCLPARQPG GLKNGSTNAG PEPACTNCFT QTTPLWRRNP
     EGQPLCNACG LFLKLHGVVR PLSLKTDVIK KRNRSSANTL TVGTSRSSKK SSRKNSIQHA
     PSTSISSRMN TSESPPSING SSTLGKPGVV PIAAAPPKSG PPAGVAQARA GVQVAPRRQR
     RLEKAPAGSE PDADDSPKSA APPSRSKVVP LAPAMAPPAA ANPANHSIAG GQGASQEWEW
     LTMSL