ID   LEC2_LATOC              Reviewed;          53 AA.
AC   P12307;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Mannose/glucose-specific lectin alpha 2 chain;
DE            Short=Lol II;
OS   Lathyrus ochrus (Cyprus-vetch) (Pisum ochrus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Fabeae; Lathyrus.
OX   NCBI_TaxID=3858;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6383863; DOI=10.1016/0014-5793(84)80573-6;
RA   Richardson M., Rouge P., Sousa-Cavada B., Yarwood A.;
RT   "The amino acid sequences of the alpha 1 and alpha 2 subunits of the
RT   isolectins from seeds of Lathyrus ochrus (L) DC.";
RL   FEBS Lett. 175:76-81(1984).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS).
RX   PubMed=1404396; DOI=10.1016/0022-2836(92)90233-a;
RA   Bourne Y., Nesa M.P., Rouge P., Mazurier J., Legrand D., Spik G.,
RA   Montreuil J., Cambillau C.;
RT   "Crystallization and preliminary X-ray diffraction study of Lathyrus ochrus
RT   isolectin II complexed to the human lactotransferrin N2 fragment.";
RL   J. Mol. Biol. 227:938-941(1992).
CC   -!- SUBUNIT: Tetramer of two alpha and two beta chains.
CC   -!- INTERACTION:
CC       P12307; P04122; NbExp=2; IntAct=EBI-16210416, EBI-9019549;
CC   -!- SIMILARITY: Belongs to the leguminous lectin family. {ECO:0000305}.
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DR   PIR; B25989; B25989.
DR   PDB; 1LGB; X-ray; 3.30 A; B=1-53.
DR   PDB; 1LGC; X-ray; 2.80 A; B/D/F=1-53.
DR   PDBsum; 1LGB; -.
DR   PDBsum; 1LGC; -.
DR   AlphaFoldDB; P12307; -.
DR   SMR; P12307; -.
DR   DIP; DIP-6191N; -.
DR   IntAct; P12307; 2.
DR   EvolutionaryTrace; P12307; -.
DR   GO; GO:0005537; F:mannose binding; IEA:UniProtKB-KW.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000985; Lectin_LegA_CS.
DR   InterPro; IPR001220; Legume_lectin_dom.
DR   Pfam; PF00139; Lectin_legB; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS00308; LECTIN_LEGUME_ALPHA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Lectin; Mannose-binding.
FT   CHAIN           1..53
FT                   /note="Mannose/glucose-specific lectin alpha 2 chain"
FT                   /id="PRO_0000105103"
FT   STRAND          2..9
FT                   /evidence="ECO:0007829|PDB:1LGC"
FT   HELIX           12..14
FT                   /evidence="ECO:0007829|PDB:1LGC"
FT   STRAND          18..27
FT                   /evidence="ECO:0007829|PDB:1LGC"
FT   STRAND          29..31
FT                   /evidence="ECO:0007829|PDB:1LGC"
FT   STRAND          34..46
FT                   /evidence="ECO:0007829|PDB:1LGC"
SQ   SEQUENCE   53 AA;  5929 MW;  06E19AB22BFDE101 CRC64;
     ETSYTLNEVV PLKEFVPEWV RIGFSATTGA EFAAHEVLSW YFNSELSVTS SSN