ID   LEC3_CAEEL              Reviewed;         297 AA.
AC   Q09581; Q9GNP6;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 3.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=32 kDa beta-galactoside-binding lectin lec-3;
DE   AltName: Full=32 kDa GBP;
GN   Name=lec-3; ORFNames=ZK892.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hirabayashi J., Hayama K., Kasai K.;
RT   "Novel galectins found in C. elegans.";
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Binds galactose. {ECO:0000250}.
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DR   EMBL; AB038504; BAB11969.1; -; mRNA.
DR   EMBL; Z48638; CAA88570.2; -; Genomic_DNA.
DR   PIR; T28073; T28073.
DR   RefSeq; NP_496159.1; NM_063758.5.
DR   AlphaFoldDB; Q09581; -.
DR   SMR; Q09581; -.
DR   BioGRID; 39877; 11.
DR   DIP; DIP-26079N; -.
DR   STRING; 6239.ZK892.1f; -.
DR   PaxDb; Q09581; -.
DR   EnsemblMetazoa; ZK892.1a.1; ZK892.1a.1; WBGene00002266.
DR   EnsemblMetazoa; ZK892.1a.2; ZK892.1a.2; WBGene00002266.
DR   GeneID; 174557; -.
DR   UCSC; ZK892.1a; c. elegans.
DR   CTD; 174557; -.
DR   WormBase; ZK892.1a; CE24743; WBGene00002266; lec-3.
DR   eggNOG; KOG3587; Eukaryota.
DR   InParanoid; Q09581; -.
DR   Reactome; R-CEL-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   Reactome; R-CEL-8957275; Post-translational protein phosphorylation.
DR   PRO; PR:Q09581; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00002266; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; Q09581; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; HDA:WormBase.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0016936; F:galactoside binding; IBA:GO_Central.
DR   CDD; cd00070; GLECT; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR001079; Galectin_CRD.
DR   PANTHER; PTHR11346; PTHR11346; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 2.
DR   SMART; SM00908; Gal-bind_lectin; 2.
DR   SMART; SM00276; GLECT; 2.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS51304; GALECTIN; 2.
PE   2: Evidence at transcript level;
KW   Lectin; Reference proteome; Repeat.
FT   CHAIN           1..297
FT                   /note="32 kDa beta-galactoside-binding lectin lec-3"
FT                   /id="PRO_0000076958"
FT   DOMAIN          11..142
FT                   /note="Galectin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   DOMAIN          151..290
FT                   /note="Galectin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   BINDING         224..230
FT                   /ligand="a beta-D-galactoside"
FT                   /ligand_id="ChEBI:CHEBI:28034"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   297 AA;  33641 MW;  A48FCED3D8644082 CRC64;
     MAEPKSFNIP YRSKLTERIE PGQTLIIRGK TIDESKRFNI NLHKDSPDFS GNDVPLHLSI
     RFDEGKIVYN AYTKGTWGKE ERAKNPIKKG DDFDIRIRAH DSKFQVSINH KEVKNFEHRI
     PLNSVSHLSI DGDVVLNHVQ WGGKYYPVPY ESGIAADGLV PGKTLVVYGT PEKKAKKFNI
     NLLKKNGDIA LHFNPRFDEK ANGFMCAKPT PGSVVRNSLV NGEWGNEERE GKNPFERLTA
     FDLEIRNEEF AFQIFVNGER FASYAHRVDP HDIAGLQIQG DIELTGIQVV NNQPAQE