ID   LEC3_CROVR              Reviewed;         224 AA.
AC   P86626;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 3.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Mannose-specific lectin 3;
DE   Contains:
DE     RecName: Full=Mannose-specific lectin 3 chain 1;
DE   Contains:
DE     RecName: Full=Mannose-specific lectin 3 chain 2;
OS   Crocus vernus (Dutch crocus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Iridaceae;
OC   Crocoideae; Croceae; Crocus.
OX   NCBI_TaxID=87752;
RN   [1] {ECO:0000305}
RP   X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS), AND DISULFIDE BONDS.
RC   TISSUE=Corm;
RA   Akrem A., Meyer A., Perbandt M., Voelter W., Buck F., Betzel C.;
RL   Submitted (MAY-2010) to UniProtKB.
CC   -!- FUNCTION: Mannose-specific lectin. Has weak agglutinating activity
CC       towards trypsin-treated erythrocytes from rabbit but not from human (By
CC       similarity). {ECO:0000250|UniProtKB:Q9FVA1}.
CC   -!- SUBUNIT: Heterotetramer of 2 domain 1 and 2 domain 2 chains arranged as
CC       a dimer of domain 1/domain 2 heterodimers. {ECO:0000250}.
CC   -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is:
CC       5.18, its MW is: 48 kDa.
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DR   PDB; 3MEZ; X-ray; 1.94 A; A/C=1-110, B/D=112-223.
DR   PDBsum; 3MEZ; -.
DR   AlphaFoldDB; P86626; -.
DR   SMR; P86626; -.
DR   UniLectin; P86626; -.
DR   EvolutionaryTrace; P86626; -.
DR   GO; GO:0005537; F:mannose binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.90.10.10; -; 2.
DR   InterPro; IPR001480; Bulb-type_lectin_dom.
DR   InterPro; IPR036426; Bulb-type_lectin_dom_sf.
DR   SMART; SM00108; B_lectin; 2.
DR   SUPFAM; SSF51110; SSF51110; 2.
DR   PROSITE; PS50927; BULB_LECTIN; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Hemagglutinin; Lectin; Mannose-binding;
KW   Repeat.
FT   CHAIN           1..111
FT                   /note="Mannose-specific lectin 3 chain 1"
FT                   /id="PRO_0000395438"
FT   CHAIN           112..224
FT                   /note="Mannose-specific lectin 3 chain 2"
FT                   /id="PRO_0000395439"
FT   DOMAIN          2..111
FT                   /note="Bulb-type lectin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00038,
FT                   ECO:0000305"
FT   DOMAIN          117..222
FT                   /note="Bulb-type lectin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00038"
FT   DISULFID        30..52
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00038,
FT                   ECO:0000269|Ref.1"
FT   DISULFID        145..170
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00038,
FT                   ECO:0000269|Ref.1"
FT   STRAND          4..6
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          16..19
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          22..26
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          32..35
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          53..56
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          62..65
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          73..79
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          88..91
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          97..100
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          102..106
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          117..121
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          125..127
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          131..134
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          137..141
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          147..151
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   TURN            152..155
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          156..160
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          171..174
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          180..183
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          189..192
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          198..200
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          203..206
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          212..215
FT                   /evidence="ECO:0007829|PDB:3MEZ"
FT   STRAND          217..222
FT                   /evidence="ECO:0007829|PDB:3MEZ"
SQ   SEQUENCE   224 AA;  24454 MW;  94C963051247B7C6 CRC64;
     DNNVLLTGDV IHTDNQLSYE SAAFVMQGDC NLVLYNEAGG FQSNTHGRGV DCTLRLNNRG
     QLEIHSANSN TPVWVYPRSV NTVRGNYAAT LGPDQHVTIY GPAIWSTPAA ANIPRVRNVL
     FSSQVMYDNA QLATRDYSLV MRDDCNLVLT KGSKTNIVWE SGTSGRGQHC FMRLGHSGEL
     DITDDRLNTV FVSNTVGQEG DYVLILQING QAVVYGPAVW STAA