ID   LEC6_TACTR              Reviewed;         221 AA.
AC   P82151;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Lectin L6;
OS   Tachypleus tridentatus (Japanese horseshoe crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Merostomata;
OC   Xiphosura; Limulidae; Tachypleus.
OX   NCBI_TaxID=6853;
RN   [1]
RP   PROTEIN SEQUENCE, DISULFIDE BONDS, AND FUNCTION.
RC   TISSUE=Hemocyte;
RX   PubMed=7782311; DOI=10.1074/jbc.270.24.14493;
RA   Saito T., Kawabata S., Hirata M., Iwanaga S.;
RT   "A novel type of limulus lectin-L6. Purification, primary structure, and
RT   antibacterial activity.";
RL   J. Biol. Chem. 270:14493-14499(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-17.
RX   PubMed=8282718; DOI=10.1093/oxfordjournals.jbchem.a124173;
RA   Shigenaga T., Takayenoki Y., Kawasaki S., Seki N., Muta T., Toh Y., Ito A.,
RA   Iwanaga S.;
RT   "Separation of large and small granules from horseshoe crab (Tachypleus
RT   tridentatus) hemocytes and characterization of their components.";
RL   J. Biochem. 114:307-316(1993).
CC   -!- FUNCTION: Lipopolysaccharide-binding protein with Gram-negative
CC       antibacterial activity. Binds zinc and calcium.
CC       {ECO:0000269|PubMed:7782311}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Note=L-
CC       granules.
CC   -!- TISSUE SPECIFICITY: Hemocytes.
CC   -!- SIMILARITY: Belongs to the tectonin family. {ECO:0000305}.
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DR   PIR; PC1318; PC1318.
DR   AlphaFoldDB; P82151; -.
DR   SMR; P82151; -.
DR   GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR   Pfam; PF19193; Tectonin; 1.
DR   SMART; SM00706; TECPR; 6.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Calcium; Cytoplasmic vesicle;
KW   Direct protein sequencing; Disulfide bond; Lectin; Metal-binding; Repeat;
KW   Zinc.
FT   CHAIN           1..221
FT                   /note="Lectin L6"
FT                   /id="PRO_0000221475"
FT   REPEAT          1..38
FT                   /note="1"
FT   REPEAT          39..75
FT                   /note="2"
FT   REPEAT          76..113
FT                   /note="3"
FT   REPEAT          114..150
FT                   /note="4"
FT   REPEAT          151..188
FT                   /note="5"
FT   REPEAT          189..221
FT                   /note="6"
FT   REGION          1..221
FT                   /note="6 X approximate tandem repeats"
FT   DISULFID        32..36
FT                   /evidence="ECO:0000269|PubMed:7782311"
FT   DISULFID        108..112
FT                   /evidence="ECO:0000269|PubMed:7782311"
FT   DISULFID        183..187
FT                   /evidence="ECO:0000269|PubMed:7782311"
SQ   SEQUENCE   221 AA;  24410 MW;  59C97CF736DF4962 CRC64;
     VQWHQIPGKL MHITATPHFL WGVNSNQQIY LCRQPCYDGQ WTQISGSLKQ VDADDHEVWG
     VNRNDDIYKR PVDGSGSWVR VSGKLKHVSA SGYGYIWGVN SNDQIYKCPK PCNGAWTQVN
     GRLKQIDGGQ SMVYGVNSAN AIYRRPVDGS GSWQQISGSL KHITGSGLSE VFGVNSNDQI
     YRCTKPCSGQ WSLIDGRLKQ CDATGNTIVG VNSVDNIYRS G