AREG_RAT
ID AREG_RAT Reviewed; 243 AA.
AC P24338;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Amphiregulin;
DE Short=AR;
DE AltName: Full=Schwannoma-derived growth factor;
DE Short=SDGF;
DE Flags: Precursor;
GN Name=Areg; Synonyms=Sdgf;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=2234093; DOI=10.1038/348257a0;
RA Kimura H., Fischer W.H., Schubert D.;
RT "Structure, expression and function of a schwannoma-derived growth
RT factor.";
RL Nature 348:257-260(1990).
CC -!- FUNCTION: Ligand of the EGF receptor/EGFR. Autocrine growth factor as
CC well as a mitogen for a broad range of target cells including
CC astrocytes, Schwann cells and fibroblasts.
CC -!- SUBUNIT: The immature precursor interacts with CNIH. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
CC -!- SIMILARITY: Belongs to the amphiregulin family. {ECO:0000305}.
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DR EMBL; X55183; CAA38967.1; -; mRNA.
DR PIR; S13296; S13296.
DR RefSeq; NP_058819.1; NM_017123.1.
DR AlphaFoldDB; P24338; -.
DR SMR; P24338; -.
DR STRING; 10116.ENSRNOP00000003703; -.
DR GlyGen; P24338; 3 sites.
DR PaxDb; P24338; -.
DR Ensembl; ENSRNOT00000003703; ENSRNOP00000003703; ENSRNOG00000002754.
DR GeneID; 29183; -.
DR KEGG; rno:29183; -.
DR UCSC; RGD:2149; rat.
DR CTD; 374; -.
DR RGD; 2149; Areg.
DR eggNOG; ENOG502S0KA; Eukaryota.
DR GeneTree; ENSGT00940000160696; -.
DR HOGENOM; CLU_096527_1_0_1; -.
DR InParanoid; P24338; -.
DR OMA; CHHDYFG; -.
DR OrthoDB; 1444868at2759; -.
DR PhylomeDB; P24338; -.
DR TreeFam; TF332773; -.
DR Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
DR Reactome; R-RNO-177929; Signaling by EGFR.
DR Reactome; R-RNO-179812; GRB2 events in EGFR signaling.
DR Reactome; R-RNO-180292; GAB1 signalosome.
DR Reactome; R-RNO-180336; SHC1 events in EGFR signaling.
DR Reactome; R-RNO-182971; EGFR downregulation.
DR Reactome; R-RNO-204005; COPII-mediated vesicle transport.
DR Reactome; R-RNO-212718; EGFR interacts with phospholipase C-gamma.
DR Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
DR Reactome; R-RNO-5694530; Cargo concentration in the ER.
DR Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Reactome; R-RNO-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-RNO-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-RNO-9009391; Extra-nuclear estrogen signaling.
DR PRO; PR:P24338; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000002754; Expressed in duodenum and 10 other tissues.
DR Genevisible; P24338; RN.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IDA:RGD.
DR GO; GO:0008083; F:growth factor activity; IDA:RGD.
DR GO; GO:0048018; F:receptor ligand activity; ISO:RGD.
DR GO; GO:0030297; F:transmembrane receptor protein tyrosine kinase activator activity; ISO:RGD.
DR GO; GO:0007417; P:central nervous system development; NAS:RGD.
DR GO; GO:0060598; P:dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis; ISO:RGD.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IDA:RGD.
DR GO; GO:0060750; P:epithelial cell proliferation involved in mammary gland duct elongation; ISO:RGD.
DR GO; GO:0038134; P:ERBB2-EGFR signaling pathway; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0014009; P:glial cell proliferation; IDA:RGD.
DR GO; GO:0060749; P:mammary gland alveolus development; ISO:RGD.
DR GO; GO:0060744; P:mammary gland branching involved in thelarche; ISO:RGD.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IDA:RGD.
DR GO; GO:0031175; P:neuron projection development; IMP:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:RGD.
DR GO; GO:0045741; P:positive regulation of epidermal growth factor-activated receptor activity; IBA:GO_Central.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR GO; GO:0042327; P:positive regulation of phosphorylation; IDA:RGD.
DR GO; GO:0051591; P:response to cAMP; IEP:RGD.
DR GO; GO:0032355; P:response to estradiol; ISO:RGD.
DR GO; GO:0051384; P:response to glucocorticoid; IMP:RGD.
DR GO; GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR015497; EGF_rcpt_ligand.
DR PANTHER; PTHR10740; PTHR10740; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 1: Evidence at protein level;
KW Cytokine; Direct protein sequencing; Disulfide bond; EGF-like domain;
KW Glycoprotein; Growth factor; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..96
FT /id="PRO_0000007478"
FT CHAIN 97..243
FT /note="Amphiregulin"
FT /id="PRO_0000007479"
FT TRANSMEM 190..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 133..173
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 55..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..135
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 236
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 137..150
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 145..161
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 163..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 243 AA; 26633 MW; F59A8173D4921599 CRC64;
MRTPSLSLAL SVLSLLVLGS GHYAAGLELN GTSSGKGEPS SGDHSAGGLV VSEVSTISEM
PSGSELSTGD YDYSEEYDNE PQISGYIVDD SVRVEQVIKP KENKTEGEKS SEKPKRKKKG
GKGGKGRRNR KKKKNPCAAK FQNFCIHGEC RYIENLEVVT CHCHQDYFGE RCGEKTMKTQ
KKDDSDLSKI ALAAIIVFVS AVSVAAIGII TAVLLRKRFF REYEEAEERR RLRQENGTAH
AIA
