ID   LECA_PHYAM              Reviewed;          64 AA.
AC   P84282;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Lectin-A;
DE   AltName: Full=PL-A;
DE   Flags: Fragments;
OS   Phytolacca americana (American pokeweed) (Phytolacca decandra).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Phytolaccaceae; Phytolacca.
OX   NCBI_TaxID=3527;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND GLYCOSYLATION.
RC   TISSUE=Root {ECO:0000269|PubMed:7772833};
RX   PubMed=7772833; DOI=10.1271/bbb.59.683;
RA   Kino M., Yamaguchi K., Umekawa H., Funatsu G.;
RT   "Purification and characterization of three mitogenic lectins from the
RT   roots of pokeweed (Phytolacca americana).";
RL   Biosci. Biotechnol. Biochem. 59:683-688(1995).
CC   -!- FUNCTION: N-acetyl-D-glucosamine binding lectin. Shows low
CC       hemagglutinating activity towards human erythrocytes. Has low mitogenic
CC       activity towards human peripheral blood lymphocytes.
CC       {ECO:0000250|UniProtKB:Q9AYP9, ECO:0000269|PubMed:7772833}.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:7772833}.
CC   -!- CAUTION: The order of the last 3 peptides shown is unknown.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P84282; -.
DR   SMR; P84282; -.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0008061; F:chitin binding; ISS:UniProtKB.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0045840; P:positive regulation of mitotic nuclear division; IDA:UniProtKB.
DR   Gene3D; 3.30.60.10; -; 1.
DR   InterPro; IPR001002; Chitin-bd_1.
DR   InterPro; IPR036861; Endochitinase-like_sf.
DR   Pfam; PF00187; Chitin_bind_1; 1.
DR   SUPFAM; SSF57016; SSF57016; 1.
PE   1: Evidence at protein level;
KW   Chitin-binding; Direct protein sequencing; Glycoprotein; Hemagglutinin;
KW   Lectin; Mitogen; Repeat.
FT   CHAIN           1..>64
FT                   /note="Lectin-A"
FT                   /id="PRO_0000124811"
FT   DOMAIN          1..20
FT                   /note="Chitin-binding type-1 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00261"
FT   DOMAIN          <22..>45
FT                   /note="Chitin-binding type-1 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00261"
FT   NON_CONS        8..9
FT                   /evidence="ECO:0000305"
FT   NON_CONS        21..22
FT                   /evidence="ECO:0000305"
FT   NON_CONS        30..31
FT                   /evidence="ECO:0000305"
FT   NON_CONS        45..46
FT                   /evidence="ECO:0000305"
FT   NON_CONS        48..49
FT                   /evidence="ECO:0000305"
FT   NON_CONS        55..56
FT                   /evidence="ECO:0000305"
FT   NON_TER         64
FT                   /evidence="ECO:0000303|PubMed:7772833"
SQ   SEQUENCE   64 AA;  7036 MW;  EC7778A975895625 CRC64;
     APECGREAHC GDDCQSQVVT RDFDDRTCPK LLCCSKDGWC GNTDANWRCG VDFGRTCPND
     LCCS