ID   LECB1_ARTIN             Reviewed;          20 AA.
AC   P18671;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Agglutinin beta-1 chain;
DE   AltName: Full=Jacalin beta-1 chain;
OS   Artocarpus integer (Jack fruit) (Artocarpus integrifolia).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Moraceae; Artocarpus.
OX   NCBI_TaxID=3490;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Seed;
RX   PubMed=2705782; DOI=10.1016/0003-9861(89)90542-0;
RA   Young N.M., Johnston R.A.Z., Szabo A.G., Watson D.C.;
RT   "Homology of the D-galactose-specific lectins from Artocarpus integrifolia
RT   and Maclura pomifera and the role of an unusual small polypeptide
RT   subunit.";
RL   Arch. Biochem. Biophys. 270:596-603(1989).
RN   [2]
RP   PROTEIN SEQUENCE.
RX   PubMed=1599414; DOI=10.1042/bj2840095;
RA   Mahanta S.K., Sanker S., Prasad Rao N.V.S.A.V., Swamy M.J., Surolia A.;
RT   "Primary structure of a Thomsen-Friedenreich-antigen-specific lectin,
RT   jacalin [Artocarpus integrifolia (jack fruit) agglutinin]. Evidence for the
RT   presence of an internal repeat.";
RL   Biochem. J. 284:95-101(1992).
RN   [3]
RP   PROTEIN SEQUENCE.
RX   PubMed=8427879; DOI=10.1016/0304-4165(93)90139-y;
RA   Ngoc L.D., Brillard M., Hoebeke J.;
RT   "The alpha- and beta-subunits of the jacalins are cleavage products from a
RT   17-kDa precursor.";
RL   Biochim. Biophys. Acta 1156:219-222(1993).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (2.43 ANGSTROMS).
RX   PubMed=8673603; DOI=10.1038/nsb0796-596;
RA   Sakaranarayanan R., Sekar S., Banerjee R., Sharma V., Surolia A.,
RA   Vijayan M.;
RT   "A novel mode of carbohydrate recognition in jacalin, a Moraceae plant
RT   lectin with a beta-prism fold.";
RL   Nat. Struct. Biol. 3:596-603(1996).
CC   -!- FUNCTION: D-galactose-specific lectin, binds the T-antigen structure
CC       Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin).
CC       Potent and selective stimulant of distinct T- and B-cell functions.
CC       Shows a unique ability to specifically recognize IgA-1 from human
CC       serum.
CC   -!- SUBUNIT: Tetramer of four alpha chains associated with two or four beta
CC       chains.
CC   -!- SIMILARITY: Belongs to the jacalin lectin family. {ECO:0000305}.
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DR   PDB; 1JAC; X-ray; 2.43 A; B/D/F/H=1-20.
DR   PDB; 1KU8; X-ray; 1.75 A; B/D/F/H=1-18.
DR   PDB; 1KUJ; X-ray; 2.00 A; B/D/F/H=1-18.
DR   PDBsum; 1JAC; -.
DR   PDBsum; 1KU8; -.
DR   PDBsum; 1KUJ; -.
DR   AlphaFoldDB; P18671; -.
DR   SMR; P18671; -.
DR   EvolutionaryTrace; P18671; -.
DR   GO; GO:0030246; F:carbohydrate binding; IDA:UniProtKB.
DR   GO; GO:0019862; F:IgA binding; ISS:UniProtKB.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; IgA-binding protein; Lectin.
FT   PEPTIDE         1..20
FT                   /note="Agglutinin beta-1 chain"
FT                   /id="PRO_0000044032"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          10..16
FT                   /evidence="ECO:0007829|PDB:1KU8"
SQ   SEQUENCE   20 AA;  2062 MW;  894AFC95F4D0E248 CRC64;
     NEQSGKSQTV IVGSWGAKVS