AREP1_ARATH
ID AREP1_ARATH Reviewed; 40 AA.
AC P0DKH9;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 07-JAN-2015, sequence version 1.
DT 03-AUG-2022, entry version 21.
DE RecName: Full=Auxin-responsive endogenous peptide 1 {ECO:0000303|PubMed:24479837};
GN Name=AREP1 {ECO:0000303|PubMed:24479837}; OrderedLocusNames=At1g01335;
GN ORFNames=F6F3 {ECO:0000312|EMBL:AC023628};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION, FUNCTION, INDUCTION BY AUXIN,
RP SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=24479837; DOI=10.1111/jipb.12178;
RA Yang F., Song Y., Yang H., Liu Z., Zhu G., Yang Y.;
RT "An auxin-responsive endogenous peptide regulates root development in
RT Arabidopsis.";
RL J. Integr. Plant Biol. 56:635-647(2014).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Negative regulator of the auxin response.
CC {ECO:0000269|PubMed:24479837}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24479837}. Nucleus
CC {ECO:0000269|PubMed:24479837}. Membrane {ECO:0000255}; Single-pass
CC membrane protein {ECO:0000255}. Note=Not localized under normal
CC conditions, but found in the cytoplasm and in the nucleus when auxin is
CC added. {ECO:0000269|PubMed:24479837}.
CC -!- TISSUE SPECIFICITY: Expressed in cotyledons, hypocotyls, roots, newly
CC developing leaves and shoot apical meristem. Not detected in flowers,
CC siliques or mature leaves. {ECO:0000269|PubMed:24479837}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the primary developmental stages.
CC {ECO:0000269|PubMed:24479837}.
CC -!- INDUCTION: Up-regulated by auxin. {ECO:0000269|PubMed:24479837}.
CC -!- MISCELLANEOUS: Knock-down mutants have no visible phenotype in the
CC absence of exogenous auxin, but are more sensitive to auxin-induced
CC inhibition of root elongation and initiation of lateral roots.
CC {ECO:0000269|PubMed:24479837}.
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DR EMBL; AC023628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; ANM60886.1; -; Genomic_DNA.
DR RefSeq; NP_001323136.1; NM_001331266.1.
DR AlphaFoldDB; P0DKH9; -.
DR PRIDE; P0DKH9; -.
DR EnsemblPlants; AT1G01335.1; AT1G01335.1; AT1G01335.
DR GeneID; 28716020; -.
DR Gramene; AT1G01335.1; AT1G01335.1; AT1G01335.
DR KEGG; ath:AT1G01335; -.
DR Araport; AT1G01335; -.
DR OrthoDB; 1897675at2759; -.
DR PRO; PR:P0DKH9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0010930; P:negative regulation of auxin mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0048364; P:root development; IMP:UniProtKB.
PE 2: Evidence at transcript level;
KW Auxin signaling pathway; Cytoplasm; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..40
FT /note="Auxin-responsive endogenous peptide 1"
FT /id="PRO_0000431425"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 40 AA; 4747 MW; F9C5C75E99E2CE63 CRC64;
MGLSDCLIYR LVVRCFLDYS ICAPFYFYHK FMLSASEPVF
