ID   LECT_GANLU              Reviewed;           8 AA.
AC   P86922;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Lectin {ECO:0000303|PubMed:21728991};
DE   Flags: Fragment;
OS   Ganoderma lucidum (Ling zhi medicinal fungus) (Bracket fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Polyporaceae; Ganoderma.
OX   NCBI_TaxID=5315;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT,
RP   GLYCOSYLATION, AND MASS SPECTROMETRY.
RC   TISSUE=Fruiting body {ECO:0000269|PubMed:21728991};
RX   PubMed=21728991; DOI=10.2174/092986611797200986;
RA   Girzal V.U., Neelagund S., Krishnappa M.;
RT   "Ganoderma lucidum: A source for novel bioactive lectin.";
RL   Protein Pept. Lett. 18:1150-1157(2011).
CC   -!- FUNCTION: Has metal-independent hemagglutinating activity against
CC       erythrocytes from human, sheep, goat, rat, rabbit and chicken.
CC       Hemagglutinating activity is inhibited by glycoproteins fetuin, asialo-
CC       fetuin, fibrinogen, asialo-fibrinogen, thyroglobulin, bovine (BSM) as
CC       well as porcine submaxillary mucin and asialo-BSM but not by sugars
CC       alpha-L-fucose, D-glucose, D-galactose, D-glucosamine, D-galactosamine,
CC       lactose, D-melibiose, D/L-mannose, D-mannosamine, D-raffinose, L-
CC       rhamnose, xylose, glacaturonic acid or N-acetylglucosamine. Has
CC       antifungal activity against F.oxysporum (MIC=20 ug/ml), P.chrysogenum
CC       (MIC=35 ug/ml), A.niger (MIC=50 ug/ml), C.musae (MIC=60 ug/ml),
CC       B.cinerea (MIC=65 ug/ml), T.rubrum (MIC=65 ug/ml), T.tonsurans (MIC=20
CC       ug/ml), T.interdigitale (MIC=20 ug/ml), E.floccosum (MIC=15 ug/ml) and
CC       M.canis (MIC=70 ug/ml). {ECO:0000269|PubMed:21728991}.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Hemagglutinating activity is stable from pH 4 to pH 9 but drops
CC         sharply below pH 4 and above pH 9. {ECO:0000269|PubMed:21728991};
CC       Temperature dependence:
CC         Hemagglutinating activity is stable below 60 degrees Celsius but
CC         drops sharply to about 20% at 80 degrees Celsius.
CC         {ECO:0000269|PubMed:21728991};
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:21728991}.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:21728991}.
CC   -!- MASS SPECTROMETRY: Mass=15090; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:21728991};
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DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0034120; P:positive regulation of erythrocyte aggregation; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Antimicrobial; Direct protein sequencing; Fruiting body; Fungicide;
KW   Glycoprotein; Hemagglutinin; Lectin.
FT   CHAIN           1..>8
FT                   /note="Lectin"
FT                   /id="PRO_0000414705"
FT   NON_TER         8
FT                   /evidence="ECO:0000303|PubMed:21728991"
SQ   SEQUENCE   8 AA;  903 MW;  C5A044137DC2C861 CRC64;
     TGVAWRIT