ID   5E5_RAT                 Reviewed;         825 AA.
AC   Q63003;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=5E5 antigen;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Brain;
RX   PubMed=8537300; DOI=10.1093/oxfordjournals.jbchem.a124866;
RA   Suzuki E., Kojima N., Yoshimura K., Uyemura K., Obata K., Akagawa K.;
RT   "Cloning and sequence analysis of cDNA for a possible DNA-binding protein
RT   5E5 in the nervous system.";
RL   J. Biochem. 118:122-128(1995).
CC   -!- FUNCTION: Might have DNA-binding ability.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in neurons.
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DR   EMBL; D37934; BAA07153.1; -; mRNA.
DR   PIR; JC4163; JC4163.
DR   AlphaFoldDB; Q63003; -.
DR   STRING; 10116.ENSRNOP00000061430; -.
DR   PaxDb; Q63003; -.
DR   PRIDE; Q63003; -.
DR   eggNOG; ENOG502R1RA; Eukaryota.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central.
DR   GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..825
FT                   /note="5E5 antigen"
FT                   /id="PRO_0000064385"
FT   REGION          126..825
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..182
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..238
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..275
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..408
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..503
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        523..541
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        641..679
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        719..733
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        802..816
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   825 AA;  86831 MW;  AF667FE2FD555BDF CRC64;
     MFLEVADLKD GLWVWKVVFL QVCIEASGWG AEVRDSCGCG DSSSHQTDDP ATALALHVAC
     HSFKGQLVQQ TLLLGTRPRV WVNNIPQEGP SLPLRQWLLP QCPSLNRSGS AMGTGWGLSG
     LSPTALSRDG YETETPFSPE GAFPGGGPAE EEGVPRPRAP PEPPDPGAPR PPPDPGPLPL
     PGSQEKPTFV VQVSTEQLLM STGGCDKEPP RGQGVDTRGD RTQEGGEKPR EQREGPRPEQ
     GPDIPGQQEE SPQQEPSSER GDSVGEREAR SPGHEGEGGG EWPGISGERR ESPGEWGADV
     PRGRGEGAGE WGSDVPKDRG EGGREWGPEA AQEHGEAARD WTSESPRTLG EDARDWGSSS
     RDAAGSSPCA LRGSLAPERL GDGPWPAWPS PQEREPGPRD RVESPREWGG TESPRGWEAG
     PREWGPSPGG RGDGPRRRPR KRRGRKGRMG RQLETTATSA SATGGPAEEA GASAPEGQAG
     GGPRGRARGP RQQARRRHGP QRRRGPPQAG EEGPGDATLV LGLGTTSGEQ RADQSQTLPA
     LAGAPTAHAH AVPGPGPAAA TLGGRGRRGS WRGGRRGGGA GASGGGRGGR GRGRGGRRGS
     GLSGTREDAG SPSARRGEQR RRGHGPPAAG AAQVSTRGRR ARGQRTGEEA QDGLLPRGRD
     RLPLRPGDSN QRVERPGHPR GGHGAINAPS APDASPPHHP RRWVSQQRQR LWRQFRVGGG
     FPPPPPTRPP PVLLPLLRLT CAGDPGASRP GSRRPARRPR GELTPQRPSP FAPQEEGLRA
     ESCVDDGAIA PDTDTASGEV PEAGPSLSST MCQMGRPRPS PKSPR