ID   LEC_PENST               Reviewed;          15 AA.
AC   P84821;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   11-DEC-2019, entry version 22.
DE   RecName: Full=Lectin 80 kDa subunit;
DE   AltName: Full=LsL;
DE   Flags: Fragment;
OS   Penaeus setiferus (Atlantic white shrimp) (Litopenaeus setiferus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=64468;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, COFACTOR, SUBUNIT, SUBCELLULAR LOCATION, AND
RP   TISSUE SPECIFICITY.
RC   TISSUE=Hemolymph {ECO:0000269|PubMed:15919156};
RX   PubMed=15919156; DOI=10.1016/j.bbagen.2005.04.014;
RA   Alpuche J., Pereyra A., Agundis C., Rosas C., Pascual C., Slomianny M.-C.,
RA   Vazquez L., Zenteno E.;
RT   "Purification and characterization of a lectin from the white shrimp
RT   Litopenaeus setiferus (Crustacea decapoda) hemolymph.";
RL   Biochim. Biophys. Acta 1724:86-93(2005).
CC   -!- FUNCTION: Sialic acid-specific lectin. Has hemagglutinating activity
CC       towards erythrocytes from several species, with high activity towards,
CC       rabbit, mouse and guinea pig erythrocytes, and low activity towards
CC       human erythrocytes. Hemagglutinating activity is blocked by treatment
CC       of erythrocytes with V.cholerae sialidase.
CC       {ECO:0000269|PubMed:15919156}.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000269|PubMed:15919156};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000269|PubMed:15919156};
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000269|PubMed:15919156};
CC       Note=Binds Ca(2+). Mn(2+) or Mg(2+) can also be used to a lesser
CC       extent. {ECO:0000269|PubMed:15919156};
CC   -!- SUBUNIT: Heterotetramer of two 80 kDa subunits and two 52 kDa subunits.
CC       {ECO:0000269|PubMed:15919156}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000269|PubMed:15919156}.
CC   -!- TISSUE SPECIFICITY: Hemolymph. {ECO:0000269|PubMed:15919156}.
CC   -!- SIMILARITY: Belongs to the tyrosinase family. Hemocyanin subfamily.
CC       {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0048029; F:monosaccharide binding; IDA:UniProtKB.
DR   GO; GO:0006959; P:humoral immune response; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hemagglutinin; Lectin; Secreted.
FT   CHAIN           1..>15
FT                   /note="Lectin 80 kDa subunit"
FT                   /evidence="ECO:0000269|PubMed:15919156"
FT                   /id="PRO_0000233933"
FT   NON_TER         15
FT                   /evidence="ECO:0000303|PubMed:15919156"
SQ   SEQUENCE   15 AA;  1700 MW;  CAC42C9DE245F0A2 CRC64;
     DASNAQKQHD VNFLL