ID   LEF11_NPVAC             Reviewed;         112 AA.
AC   P21288;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   29-SEP-2021, entry version 67.
DE   RecName: Full=Late expression factor 11;
GN   Name=LEF-11; ORFNames=ORF37;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2219715; DOI=10.1016/0042-6822(90)90266-t;
RA   Guarino L.A., Smith M.W.;
RT   "Nucleotide sequence and characterization of the 39K gene region of
RT   Autographa californica nuclear polyhedrosis virus.";
RL   Virology 179:1-8(1990).
RN   [3]
RP   CHARACTERIZATION.
RX   PubMed=7815564; DOI=10.1128/jvi.69.2.968-974.1995;
RA   Todd J.W., Passarelli A.L., Miller L.K.;
RT   "Eighteen baculovirus genes, including lef-11, p35, 39K, and p47, support
RT   late gene expression.";
RL   J. Virol. 69:968-974(1995).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=11514741; DOI=10.1099/0022-1317-82-9-2289;
RA   Lin G., Slack J.M., Blissard G.W.;
RT   "Expression and localization of LEF-11 in Autographa californica
RT   nucleopolyhedrovirus-infected Sf9 cells.";
RL   J. Gen. Virol. 82:2289-2294(2001).
RN   [5]
RP   FUNCTION.
RX   PubMed=11861844; DOI=10.1128/jvi.76.6.2770-2779.2002;
RA   Lin G., Blissard G.W.;
RT   "Analysis of an Autographa californica nucleopolyhedrovirus lef-11
RT   knockout: LEF-11 is essential for viral DNA replication.";
RL   J. Virol. 76:2770-2779(2002).
RN   [6]
RP   SUBUNIT, AND FUNCTION.
RX   PubMed=26660313; DOI=10.1371/journal.pone.0144930;
RA   Dong Z.Q., Hu N., Zhang J., Chen T.T., Cao M.Y., Li H.Q., Lei X.J.,
RA   Chen P., Lu C., Pan M.H.;
RT   "Oligomerization of baculovirus LEF-11 is involved in viral DNA
RT   replication.";
RL   PLoS ONE 10:E0144930-E0144930(2015).
CC   -!- FUNCTION: Plays an essential role in viral genome replication. Involved
CC       also in late/very late gene activation. {ECO:0000269|PubMed:11861844,
CC       ECO:0000269|PubMed:26660313}.
CC   -!- SUBUNIT: Homooligomer. {ECO:0000269|PubMed:26660313}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:11514741}.
CC   -!- SIMILARITY: Belongs to the baculoviridae LEF-11 family. {ECO:0000305}.
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DR   EMBL; L22858; AAA66667.1; -; Genomic_DNA.
DR   EMBL; M37122; AAA46683.1; -; Genomic_DNA.
DR   PIR; C45355; C45355.
DR   RefSeq; NP_054066.1; NC_001623.1.
DR   GeneID; 1403869; -.
DR   KEGG; vg:1403869; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0039693; P:viral DNA genome replication; IDA:UniProtKB.
DR   InterPro; IPR009429; Baculo_LEF-11.
DR   Pfam; PF06385; Baculo_LEF-11; 1.
PE   1: Evidence at protein level;
KW   DNA replication; Host nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Viral DNA replication.
FT   CHAIN           1..112
FT                   /note="Late expression factor 11"
FT                   /id="PRO_0000132834"
FT   REGION          42..61
FT                   /note="Dimer 1 domain"
FT                   /evidence="ECO:0000269|PubMed:26660313"
FT   REGION          72..101
FT                   /note="Dimer 2 domain"
FT                   /evidence="ECO:0000269|PubMed:26660313"
SQ   SEQUENCE   112 AA;  13129 MW;  6DCA5F6ED55C9E6C CRC64;
     MPPKNCTHLG GCDSDCLTRS EIQALFREAI NTLKHTMNTE NVCAHMLDIV SFERIKEYIR
     ANLGHFTVIT DKCSKRKVCL HHKRIARLLG IKKIYHQEYK RVVSKVYKKQ TW