ID   LEF3_NPVOP              Reviewed;         373 AA.
AC   Q65365; O12555; O12844;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Late expression factor 3;
GN   Name=LEF-3; ORFNames=ORF72;
OS   Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=262177;
OH   NCBI_TaxID=33414; Orgyia pseudotsugata (Douglas-fir tussock moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7618274; DOI=10.1006/viro.1995.1353;
RA   Ahrens C.H., Carlson C., Rohrmann G.F.;
RT   "Identification, sequence, and transcriptional analysis of lef-3, a gene
RT   essential for Orgyia pseudotsugata baculovirus DNA replication.";
RL   Virology 210:372-382(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9126251; DOI=10.1006/viro.1997.8448;
RA   Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.;
RT   "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear
RT   polyhedrosis virus genome.";
RL   Virology 229:381-399(1997).
CC   -!- FUNCTION: Required for late and very late gene expression. Lef-3 could
CC       be a single-stranded DNA-binding protein.
CC   -!- SUBUNIT: Interacts with alkaline nuclease. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the baculoviridae LEF-3 family. {ECO:0000305}.
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DR   EMBL; D45397; BAA08237.1; -; Genomic_DNA.
DR   EMBL; U75930; AAC59071.1; -; Genomic_DNA.
DR   RefSeq; NP_046228.1; NC_001875.2.
DR   PRIDE; Q65365; -.
DR   GeneID; 912018; -.
DR   KEGG; vg:912018; -.
DR   Proteomes; UP000009248; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0019079; P:viral genome replication; ISS:UniProtKB.
DR   InterPro; IPR008415; Baculo_LEF-3.
DR   Pfam; PF05847; Baculo_LEF-3; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Early protein; Host nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..373
FT                   /note="Late expression factor 3"
FT                   /id="PRO_0000132823"
SQ   SEQUENCE   373 AA;  42593 MW;  919F3DF89D918E53 CRC64;
     MMAAKREHAD CGAEPARKRV KENYKRVTGK LLSKMTISLE NHLYYTFTFR LLNENKTEAY
     YGNLQCFKDL VEQECYDVSL NFVKTKYNER IEINEYSKCD AAIDENVAVK LCLTRADFEN
     EEIVNVLAKL KCVFKRLGAN NYKMVFDINM QDAGGAVFVQ QVECFANLKV LASAAKAFVK
     SPDNFNSLMD FYYKNTNTLF YVHGVRCQHT SKGQNEFLNW TAGPSTSLET PSNTDNEDYI
     NLVHSHSTNN ISRANKHLKS MQLSLFKAEQ KINDNGKHSF SVQFKTLDSM DDDDDTKWHK
     CVYYVDSNGN KEDPNDTNAV QKLAMDFDQL ATCLADKLTK ATIFVTADNA DASTMNLLGL
     LKHDDEECEY QFL