ID   LEF7_NPVAC              Reviewed;         226 AA.
AC   P41677;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   29-SEP-2021, entry version 50.
DE   RecName: Full=Late expression factor 7;
GN   Name=LEF-7;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L1;
RX   PubMed=8178427; DOI=10.1006/viro.1994.1200;
RA   Morris T.D., Todd J.W., Fisher B., Miller L.K.;
RT   "Identification of lef-7: a baculovirus gene affecting late gene
RT   expression.";
RL   Virology 200:360-369(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [3]
RP   FUNCTION, INTERACTION WITH HOST SKP1, AND SUBCELLULAR LOCATION.
RX   PubMed=24027328; DOI=10.1128/jvi.02501-13;
RA   Mitchell J.K., Byers N.M., Friesen P.D.;
RT   "Baculovirus F-box protein LEF-7 modifies the host DNA damage response to
RT   enhance virus multiplication.";
RL   J. Virol. 87:12592-12599(2013).
CC   -!- FUNCTION: F-box protein that manipulates the host DNA damage response
CC       (DRR) in order to promote viral multiplication. Acts as a substrate
CC       recognition component of SKP1/Cullin/F-box (SCF) complexes for targeted
CC       protein polyubiquitination. {ECO:0000269|PubMed:24027328}.
CC   -!- PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway.
CC       {ECO:0000269|PubMed:24027328}.
CC   -!- SUBUNIT: Interacts with host S-phase kinase-associated protein 1/SKP1.
CC       {ECO:0000269|PubMed:24027328}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:24027328}.
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DR   EMBL; U01142; AAA19443.1; -; Unassigned_DNA.
DR   EMBL; L22858; AAA66755.1; -; Genomic_DNA.
DR   PIR; F72865; F72865.
DR   RefSeq; NP_054155.1; NC_001623.1.
DR   GeneID; 1403958; -.
DR   KEGG; vg:1403958; -.
DR   UniPathway; UPA00144; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:UniProtKB-UniPathway.
DR   PROSITE; PS50181; FBOX; 1.
PE   1: Evidence at protein level;
KW   Host nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Ubl conjugation pathway.
FT   CHAIN           1..226
FT                   /note="Late expression factor 7"
FT                   /id="PRO_0000132829"
FT   DOMAIN          9..58
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ   SEQUENCE   226 AA;  26612 MW;  561B707388BA8B2E CRC64;
     MSSVTKRPRA KRIRLPLEII DTILQYLDPI LHAKVVGLTT RVKCRLLRDN NVEDYLKLTP
     ASYHPTTDQF ICNYLGITNQ PMAPYLVPLL SFGKASCVFF NKCIPEDVRI VTLNWPLPLL
     ENFLSKQFLW YKLARKLIEH ERRMDRCVTP STVQINLYDD NEDYLNCFNC FNCCKDNLVS
     FNCCIVDCNI NDMNRCPDLQ IDVYLDDNII SLYLYFLFRI YRIVKE