ID   LEG10_MOUSE             Reviewed;          68 AA.
AC   P97400;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Galectin-10;
DE            Short=Gal-10;
DE   AltName: Full=Charcot-Leyden crystal protein homolog;
DE            Short=CLC;
DE   Flags: Fragment;
GN   Name=Clc; Synonyms=Clcp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9119387; DOI=10.1006/geno.1996.4590;
RA   Dyer K.D., Handen J.S., Rosenberg H.F.;
RT   "The genomic structure of the human Charcot-Leyden crystal protein gene is
RT   analogous to those of the galectin genes.";
RL   Genomics 40:217-221(1997).
CC   -!- FUNCTION: Regulates immune responses through the recognition of cell-
CC       surface glycans. Essential for the anergy and suppressive function of
CC       CD25-positive regulatory T-cells (Treg) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CEL. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic
CC       granule {ECO:0000250}. Note=Localized in granules from where it may be
CC       secreted or transported to other locations in the cell. {ECO:0000250}.
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DR   EMBL; U67985; AAB41694.1; -; Genomic_DNA.
DR   AlphaFoldDB; P97400; -.
DR   SMR; P97400; -.
DR   PhosphoSitePlus; P97400; -.
DR   PRIDE; P97400; -.
DR   MGI; MGI:891997; Clc.
DR   InParanoid; P97400; -.
DR   ChiTaRS; Clic1; mouse.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P97400; protein.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0046006; P:regulation of activated T cell proliferation; ISS:UniProtKB.
DR   GO; GO:0002667; P:regulation of T cell anergy; ISS:UniProtKB.
DR   GO; GO:0002724; P:regulation of T cell cytokine production; ISS:UniProtKB.
DR   GO; GO:0070231; P:T cell apoptotic process; ISS:UniProtKB.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR030648; Galectin_10.
DR   InterPro; IPR001079; Galectin_CRD.
DR   PANTHER; PTHR11346; PTHR11346; 1.
DR   PANTHER; PTHR11346:SF15; PTHR11346:SF15; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lectin; Reference proteome.
FT   CHAIN           <1..>68
FT                   /note="Galectin-10"
FT                   /id="PRO_0000076961"
FT   DOMAIN          <1..>68
FT                   /note="Galectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   NON_TER         1
FT   NON_TER         68
SQ   SEQUENCE   68 AA;  8037 MW;  3B4257F4734F7019 CRC64;
     EPYLQVDFHT EMKEDSDIAF HSRVYFGHWV VMNSRVNGAW QYEVTCHNMP FQDGKPFNLS
     ISVPPDKY