LEG16_HUMAN
ID LEG16_HUMAN Reviewed; 142 AA.
AC A8MUM7; C5HZ26;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Galectin-16 {ECO:0000312|EMBL:ACR09652.1};
GN Name=LGALS16 {ECO:0000312|EMBL:ACR09652.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ACR09652.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Placenta {ECO:0000312|EMBL:ACR09652.1};
RX PubMed=19497882; DOI=10.1073/pnas.0903568106;
RA Than N.G., Romero R., Goodman M., Weckle A., Xing J., Dong Z., Xu Y.,
RA Tarquini F., Szilagyi A., Gal P., Hou Z., Tarca A.L., Kim C.J., Kim J.S.,
RA Haidarian S., Uddin M., Bohn H., Benirschke K., Santolaya-Forgas J.,
RA Grossman L.I., Erez O., Hassan S.S., Zavodszky P., Papp Z., Wildman D.E.;
RT "A primate subfamily of galectins expressed at the maternal-fetal interface
RT that promote immune cell death.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:9731-9736(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: Binds lactose with high affinity. Strong inducer of T-cell
CC apoptosis. {ECO:0000269|PubMed:19497882}.
CC -!- TISSUE SPECIFICITY: Predominantly and highly expressed in the placenta
CC where it is localized mainly in the syncytiotrophoblast and in the
CC endothelia of fetal vessels. Also detected in the amnion and chorionic
CC trophoblasts in fetal membranes. {ECO:0000269|PubMed:19497882}.
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DR EMBL; FJ613352; ACR09652.1; -; mRNA.
DR EMBL; AC005515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS54267.1; -.
DR RefSeq; NP_001177370.2; NM_001190441.2.
DR PDB; 6LJP; X-ray; 2.00 A; A=1-142.
DR PDB; 6LJQ; X-ray; 1.49 A; A=1-142.
DR PDB; 6LJR; X-ray; 2.00 A; A=1-142.
DR PDBsum; 6LJP; -.
DR PDBsum; 6LJQ; -.
DR PDBsum; 6LJR; -.
DR AlphaFoldDB; A8MUM7; -.
DR STRING; 9606.ENSP00000375904; -.
DR UniLectin; A8MUM7; -.
DR BioMuta; LGALS16; -.
DR MassIVE; A8MUM7; -.
DR PaxDb; A8MUM7; -.
DR PeptideAtlas; A8MUM7; -.
DR PRIDE; A8MUM7; -.
DR DNASU; 148003; -.
DR Ensembl; ENST00000392051.4; ENSP00000375904.2; ENSG00000249861.4.
DR GeneID; 148003; -.
DR KEGG; hsa:148003; -.
DR MANE-Select; ENST00000392051.4; ENSP00000375904.2; NM_001190441.3; NP_001177370.2.
DR UCSC; uc021uun.2; human.
DR CTD; 148003; -.
DR DisGeNET; 148003; -.
DR GeneCards; LGALS16; -.
DR HGNC; HGNC:40039; LGALS16.
DR HPA; ENSG00000249861; Tissue enriched (placenta).
DR neXtProt; NX_A8MUM7; -.
DR OpenTargets; ENSG00000249861; -.
DR VEuPathDB; HostDB:ENSG00000249861; -.
DR eggNOG; KOG3587; Eukaryota.
DR GeneTree; ENSGT00940000162909; -.
DR HOGENOM; CLU_037794_4_0_1; -.
DR InParanoid; A8MUM7; -.
DR OrthoDB; 829777at2759; -.
DR PhylomeDB; A8MUM7; -.
DR TreeFam; TF315551; -.
DR PathwayCommons; A8MUM7; -.
DR BioGRID-ORCS; 148003; 5 hits in 1054 CRISPR screens.
DR GenomeRNAi; 148003; -.
DR Pharos; A8MUM7; Tbio.
DR PRO; PR:A8MUM7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A8MUM7; protein.
DR Bgee; ENSG00000249861; Expressed in placenta and 17 other tissues.
DR ExpressionAtlas; A8MUM7; baseline and differential.
DR GO; GO:0030395; F:lactose binding; IDA:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0070234; P:positive regulation of T cell apoptotic process; IDA:UniProtKB.
DR CDD; cd00070; GLECT; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR030650; Galectin-16.
DR InterPro; IPR044156; Galectin-like.
DR InterPro; IPR001079; Galectin_CRD.
DR PANTHER; PTHR11346; PTHR11346; 1.
DR PANTHER; PTHR11346:SF166; PTHR11346:SF166; 1.
DR Pfam; PF00337; Gal-bind_lectin; 1.
DR SMART; SM00908; Gal-bind_lectin; 1.
DR SMART; SM00276; GLECT; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS51304; GALECTIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Apoptosis; Lectin; Reference proteome.
FT CHAIN 1..142
FT /note="Galectin-16"
FT /id="PRO_0000413535"
FT DOMAIN 6..138
FT /note="Galectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT VARIANT 97
FT /note="H -> L (in dbSNP:rs1860134)"
FT /id="VAR_065877"
FT STRAND 6..11
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 19..25
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 31..33
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 35..45
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 50..57
FT /evidence="ECO:0007829|PDB:6LJQ"
FT TURN 58..60
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 61..68
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 76..79
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 87..95
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 97..104
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 107..113
FT /evidence="ECO:0007829|PDB:6LJQ"
FT HELIX 118..120
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 123..129
FT /evidence="ECO:0007829|PDB:6LJQ"
FT STRAND 131..138
FT /evidence="ECO:0007829|PDB:6LJQ"
SQ SEQUENCE 142 AA; 16600 MW; 65D0A23A252530D4 CRC64;
MSFLTVPYKL PVSLSVGSCV IIKGTLIDSS INEPQLQVDF YTEMNEDSEI AFHLRVHLGR
RVVMNSREFG IWMLEENLHY VPFEDGKPFD LRIYVCHNEY EVKVNGEYIY AFVHRIPPSY
VKMIQVWRDV SLDSVLVNNG RR
