LEG1H_MOUSE
ID LEG1H_MOUSE Reviewed; 337 AA.
AC Q8C6C9; Q8C6D2; Q8C6D6; Q8VDJ0; Q9CPV8; Q9CQ55; Q9D6S4; Q9D745; Q9D775;
AC Q9D7F4; Q9D865;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein LEG1 homolog {ECO:0000250|UniProtKB:A5PF61, ECO:0000250|UniProtKB:Q4QRF7};
DE Flags: Precursor;
GN Name=Leg1 {ECO:0000250|UniProtKB:A5PF61, ECO:0000250|UniProtKB:Q4QRF7};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-337.
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in early liver development.
CC {ECO:0000250|UniProtKB:A5PF61, ECO:0000250|UniProtKB:Q4QRF7}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A5PF61,
CC ECO:0000250|UniProtKB:Q4QRF7}.
CC -!- SIMILARITY: Belongs to the LEG1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21783.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB26311.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB26664.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK008407; BAB25653.1; -; mRNA.
DR EMBL; AK009278; BAB26189.1; -; mRNA.
DR EMBL; AK009369; BAB26247.1; -; mRNA.
DR EMBL; AK009472; BAB26311.1; ALT_INIT; mRNA.
DR EMBL; AK009516; BAB26334.1; -; mRNA.
DR EMBL; AK009594; BAB26380.1; -; mRNA.
DR EMBL; AK009610; BAB26391.1; -; mRNA.
DR EMBL; AK009872; BAB26555.1; -; mRNA.
DR EMBL; AK009911; BAB26580.1; -; mRNA.
DR EMBL; AK009921; BAB26585.1; -; mRNA.
DR EMBL; AK010028; BAB26653.1; -; mRNA.
DR EMBL; AK010037; BAB26657.1; -; mRNA.
DR EMBL; AK010047; BAB26664.1; ALT_INIT; mRNA.
DR EMBL; AK010108; BAB26706.1; -; mRNA.
DR EMBL; AK010222; BAB26777.1; -; mRNA.
DR EMBL; AK075881; BAC36026.1; -; mRNA.
DR EMBL; AK075892; BAC36034.1; -; mRNA.
DR EMBL; AK075901; BAC36041.1; -; mRNA.
DR EMBL; BC021783; AAH21783.1; ALT_INIT; mRNA.
DR CCDS; CCDS23759.1; -.
DR RefSeq; NP_080612.1; NM_026336.3.
DR AlphaFoldDB; Q8C6C9; -.
DR SMR; Q8C6C9; -.
DR STRING; 10090.ENSMUSP00000015663; -.
DR GlyGen; Q8C6C9; 1 site.
DR PhosphoSitePlus; Q8C6C9; -.
DR CPTAC; non-CPTAC-3469; -.
DR PaxDb; Q8C6C9; -.
DR PeptideAtlas; Q8C6C9; -.
DR PRIDE; Q8C6C9; -.
DR Antibodypedia; 49859; 164 antibodies from 17 providers.
DR DNASU; 67719; -.
DR Ensembl; ENSMUST00000015663; ENSMUSP00000015663; ENSMUSG00000015519.
DR GeneID; 67719; -.
DR KEGG; mmu:67719; -.
DR UCSC; uc007esr.2; mouse.
DR MGI; MGI:1914969; 2310057J18Rik.
DR VEuPathDB; HostDB:ENSMUSG00000015519; -.
DR eggNOG; ENOG502QVPP; Eukaryota.
DR GeneTree; ENSGT00390000004904; -.
DR HOGENOM; CLU_071068_0_0_1; -.
DR InParanoid; Q8C6C9; -.
DR OMA; DIEPPLW; -.
DR OrthoDB; 1401349at2759; -.
DR PhylomeDB; Q8C6C9; -.
DR TreeFam; TF332991; -.
DR BioGRID-ORCS; 67719; 1 hit in 72 CRISPR screens.
DR ChiTaRS; 2310057J18Rik; mouse.
DR PRO; PR:Q8C6C9; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8C6C9; protein.
DR Bgee; ENSMUSG00000015519; Expressed in parotid gland and 18 other tissues.
DR ExpressionAtlas; Q8C6C9; baseline and differential.
DR Genevisible; Q8C6C9; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR InterPro; IPR008499; Leg1.
DR PANTHER; PTHR18820; PTHR18820; 1.
DR Pfam; PF05612; Leg1; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..337
FT /note="Protein LEG1 homolog"
FT /id="PRO_0000252386"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 20
FT /note="A -> S (in Ref. 1; BAB26334/BAC36026)"
FT /evidence="ECO:0000305"
FT CONFLICT 21
FT /note="E -> G (in Ref. 1; BAC36026)"
FT /evidence="ECO:0000305"
FT CONFLICT 51
FT /note="I -> K (in Ref. 1; BAC36026)"
FT /evidence="ECO:0000305"
FT CONFLICT 60
FT /note="R -> K (in Ref. 1; BAC36026)"
FT /evidence="ECO:0000305"
FT CONFLICT 65
FT /note="R -> K (in Ref. 1; BAC36026)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="D -> N (in Ref. 1; BAC36026)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="T -> M (in Ref. 1; BAB26334/BAC36026)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="F -> C (in Ref. 1; BAB26189)"
FT /evidence="ECO:0000305"
FT CONFLICT 274
FT /note="T -> A (in Ref. 1; BAB26391)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="D -> E (in Ref. 1; BAB25653)"
FT /evidence="ECO:0000305"
FT CONFLICT 332
FT /note="F -> S (in Ref. 1; BAB26653)"
FT /evidence="ECO:0000305"
FT CONFLICT 334
FT /note="A -> V (in Ref. 2; AAH21783)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 337 AA; 38284 MW; C3F366FAC48436B2 CRC64;
MAVLASWVWV LAGCFCAAVA EVSDSSDPYP PLWEDSPEQL SDYMMEDGNY IINPWVYTDR
MGMYRILLEE TAMYFAKYGP ENEQNLLWGL PLQFGWQYQS GRLADPTGMT DCGNELNESL
CVSVDSWWAD INYYLSVIPF LAAVDSGITG ISPNQITILP PPKDQMRFCY NVSDCQSAVP
GTMNRWRDFF QYMQLNSSDF DGLLNYLWEA HASSLDYPTS AFGDRYNFYS EKEANFEENW
AIAVNYLAAA RLPTTQNRTY SFQRGLPPRV LVDTDIAPFI PDFTPLQNEV LVSLKLLGDT
DRNSGSLSLT LWENLMSTKL ARTLFLKAFE EFLATSS
