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LEG1H_MOUSE
ID   LEG1H_MOUSE             Reviewed;         337 AA.
AC   Q8C6C9; Q8C6D2; Q8C6D6; Q8VDJ0; Q9CPV8; Q9CQ55; Q9D6S4; Q9D745; Q9D775;
AC   Q9D7F4; Q9D865;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Protein LEG1 homolog {ECO:0000250|UniProtKB:A5PF61, ECO:0000250|UniProtKB:Q4QRF7};
DE   Flags: Precursor;
GN   Name=Leg1 {ECO:0000250|UniProtKB:A5PF61, ECO:0000250|UniProtKB:Q4QRF7};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Small intestine, and Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-337.
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in early liver development.
CC       {ECO:0000250|UniProtKB:A5PF61, ECO:0000250|UniProtKB:Q4QRF7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A5PF61,
CC       ECO:0000250|UniProtKB:Q4QRF7}.
CC   -!- SIMILARITY: Belongs to the LEG1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH21783.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB26311.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB26664.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK008407; BAB25653.1; -; mRNA.
DR   EMBL; AK009278; BAB26189.1; -; mRNA.
DR   EMBL; AK009369; BAB26247.1; -; mRNA.
DR   EMBL; AK009472; BAB26311.1; ALT_INIT; mRNA.
DR   EMBL; AK009516; BAB26334.1; -; mRNA.
DR   EMBL; AK009594; BAB26380.1; -; mRNA.
DR   EMBL; AK009610; BAB26391.1; -; mRNA.
DR   EMBL; AK009872; BAB26555.1; -; mRNA.
DR   EMBL; AK009911; BAB26580.1; -; mRNA.
DR   EMBL; AK009921; BAB26585.1; -; mRNA.
DR   EMBL; AK010028; BAB26653.1; -; mRNA.
DR   EMBL; AK010037; BAB26657.1; -; mRNA.
DR   EMBL; AK010047; BAB26664.1; ALT_INIT; mRNA.
DR   EMBL; AK010108; BAB26706.1; -; mRNA.
DR   EMBL; AK010222; BAB26777.1; -; mRNA.
DR   EMBL; AK075881; BAC36026.1; -; mRNA.
DR   EMBL; AK075892; BAC36034.1; -; mRNA.
DR   EMBL; AK075901; BAC36041.1; -; mRNA.
DR   EMBL; BC021783; AAH21783.1; ALT_INIT; mRNA.
DR   CCDS; CCDS23759.1; -.
DR   RefSeq; NP_080612.1; NM_026336.3.
DR   AlphaFoldDB; Q8C6C9; -.
DR   SMR; Q8C6C9; -.
DR   STRING; 10090.ENSMUSP00000015663; -.
DR   GlyGen; Q8C6C9; 1 site.
DR   PhosphoSitePlus; Q8C6C9; -.
DR   CPTAC; non-CPTAC-3469; -.
DR   PaxDb; Q8C6C9; -.
DR   PeptideAtlas; Q8C6C9; -.
DR   PRIDE; Q8C6C9; -.
DR   Antibodypedia; 49859; 164 antibodies from 17 providers.
DR   DNASU; 67719; -.
DR   Ensembl; ENSMUST00000015663; ENSMUSP00000015663; ENSMUSG00000015519.
DR   GeneID; 67719; -.
DR   KEGG; mmu:67719; -.
DR   UCSC; uc007esr.2; mouse.
DR   MGI; MGI:1914969; 2310057J18Rik.
DR   VEuPathDB; HostDB:ENSMUSG00000015519; -.
DR   eggNOG; ENOG502QVPP; Eukaryota.
DR   GeneTree; ENSGT00390000004904; -.
DR   HOGENOM; CLU_071068_0_0_1; -.
DR   InParanoid; Q8C6C9; -.
DR   OMA; DIEPPLW; -.
DR   OrthoDB; 1401349at2759; -.
DR   PhylomeDB; Q8C6C9; -.
DR   TreeFam; TF332991; -.
DR   BioGRID-ORCS; 67719; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; 2310057J18Rik; mouse.
DR   PRO; PR:Q8C6C9; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q8C6C9; protein.
DR   Bgee; ENSMUSG00000015519; Expressed in parotid gland and 18 other tissues.
DR   ExpressionAtlas; Q8C6C9; baseline and differential.
DR   Genevisible; Q8C6C9; MM.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   InterPro; IPR008499; Leg1.
DR   PANTHER; PTHR18820; PTHR18820; 1.
DR   Pfam; PF05612; Leg1; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..337
FT                   /note="Protein LEG1 homolog"
FT                   /id="PRO_0000252386"
FT   CARBOHYD        171
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        20
FT                   /note="A -> S (in Ref. 1; BAB26334/BAC36026)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        21
FT                   /note="E -> G (in Ref. 1; BAC36026)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        51
FT                   /note="I -> K (in Ref. 1; BAC36026)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        60
FT                   /note="R -> K (in Ref. 1; BAC36026)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        65
FT                   /note="R -> K (in Ref. 1; BAC36026)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        111
FT                   /note="D -> N (in Ref. 1; BAC36026)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        157
FT                   /note="T -> M (in Ref. 1; BAB26334/BAC36026)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        262
FT                   /note="F -> C (in Ref. 1; BAB26189)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        274
FT                   /note="T -> A (in Ref. 1; BAB26391)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        301
FT                   /note="D -> E (in Ref. 1; BAB25653)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        332
FT                   /note="F -> S (in Ref. 1; BAB26653)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        334
FT                   /note="A -> V (in Ref. 2; AAH21783)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   337 AA;  38284 MW;  C3F366FAC48436B2 CRC64;
     MAVLASWVWV LAGCFCAAVA EVSDSSDPYP PLWEDSPEQL SDYMMEDGNY IINPWVYTDR
     MGMYRILLEE TAMYFAKYGP ENEQNLLWGL PLQFGWQYQS GRLADPTGMT DCGNELNESL
     CVSVDSWWAD INYYLSVIPF LAAVDSGITG ISPNQITILP PPKDQMRFCY NVSDCQSAVP
     GTMNRWRDFF QYMQLNSSDF DGLLNYLWEA HASSLDYPTS AFGDRYNFYS EKEANFEENW
     AIAVNYLAAA RLPTTQNRTY SFQRGLPPRV LVDTDIAPFI PDFTPLQNEV LVSLKLLGDT
     DRNSGSLSLT LWENLMSTKL ARTLFLKAFE EFLATSS
 
 
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