LEG1_PODHI
ID LEG1_PODHI Reviewed; 58 AA.
AC P82447;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Galectin-1;
DE Short=Gal-1;
DE Flags: Fragment;
OS Podarcis hispanicus (Iberian wall lizard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Lacertibaenia; Lacertidae; Podarcis.
OX NCBI_TaxID=74081;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC TISSUE=Skin;
RX PubMed=11159924; DOI=10.1093/glycob/10.12.1325;
RA Solis D., Lopez-Lucendo M.I.F., Leon S., Varela J., Diaz-Maurino T.;
RT "Description of a monomeric prototype galectin from the lizard Podarcis
RT hispanica.";
RL Glycobiology 10:1325-1331(2000).
CC -!- FUNCTION: May regulate cell apoptosis and cell differentiation. Binds
CC beta-galactoside and a wide array of complex carbohydrates (By
CC similarity). {ECO:0000250, ECO:0000269|PubMed:11159924}.
CC -!- SUBUNIT: Monomer.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Detected in most tissues, most abundantly in skin.
CC -!- MASS SPECTROMETRY: Mass=14500; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11159924};
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001079; Galectin_CRD.
DR Pfam; PF00337; Gal-bind_lectin; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS51304; GALECTIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Extracellular matrix; Lectin; Secreted.
FT CHAIN 1..>58
FT /note="Galectin-1"
FT /id="PRO_0000076923"
FT DOMAIN 2..>58
FT /note="Galectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT BINDING 43..47
FT /ligand="a beta-D-galactoside"
FT /ligand_id="ChEBI:CHEBI:28034"
FT /evidence="ECO:0000250"
FT BINDING 51
FT /ligand="a beta-D-galactoside"
FT /ligand_id="ChEBI:CHEBI:28034"
FT /evidence="ECO:0000250"
FT NON_TER 58
SQ SEQUENCE 58 AA; 6131 MW; 799B1D5A68A2F792 CRC64;
PGITXTSLHV APGARLAVKG DIPAGAKSWV INLGKGENDI MLHFNARFDA HGDIRTIV