ID   LEG1_PODHI              Reviewed;          58 AA.
AC   P82447;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Galectin-1;
DE            Short=Gal-1;
DE   Flags: Fragment;
OS   Podarcis hispanicus (Iberian wall lizard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC   Lacertibaenia; Lacertidae; Podarcis.
OX   NCBI_TaxID=74081;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Skin;
RX   PubMed=11159924; DOI=10.1093/glycob/10.12.1325;
RA   Solis D., Lopez-Lucendo M.I.F., Leon S., Varela J., Diaz-Maurino T.;
RT   "Description of a monomeric prototype galectin from the lizard Podarcis
RT   hispanica.";
RL   Glycobiology 10:1325-1331(2000).
CC   -!- FUNCTION: May regulate cell apoptosis and cell differentiation. Binds
CC       beta-galactoside and a wide array of complex carbohydrates (By
CC       similarity). {ECO:0000250, ECO:0000269|PubMed:11159924}.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Detected in most tissues, most abundantly in skin.
CC   -!- MASS SPECTROMETRY: Mass=14500; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:11159924};
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001079; Galectin_CRD.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Extracellular matrix; Lectin; Secreted.
FT   CHAIN           1..>58
FT                   /note="Galectin-1"
FT                   /id="PRO_0000076923"
FT   DOMAIN          2..>58
FT                   /note="Galectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   BINDING         43..47
FT                   /ligand="a beta-D-galactoside"
FT                   /ligand_id="ChEBI:CHEBI:28034"
FT                   /evidence="ECO:0000250"
FT   BINDING         51
FT                   /ligand="a beta-D-galactoside"
FT                   /ligand_id="ChEBI:CHEBI:28034"
FT                   /evidence="ECO:0000250"
FT   NON_TER         58
SQ   SEQUENCE   58 AA;  6131 MW;  799B1D5A68A2F792 CRC64;
     PGITXTSLHV APGARLAVKG DIPAGAKSWV INLGKGENDI MLHFNARFDA HGDIRTIV