LEG2_MOUSE
ID LEG2_MOUSE Reviewed; 130 AA.
AC Q9CQW5; Q9D800; Q9D862;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Galectin-2;
DE Short=Gal-2;
GN Name=Lgals2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas, Small intestine, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: This protein binds beta-galactoside. Its physiological
CC function is not yet known.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR EMBL; AK007364; BAB24987.1; -; mRNA.
DR EMBL; AK008423; BAB25661.1; -; mRNA.
DR EMBL; AK008636; BAB25797.1; -; mRNA.
DR EMBL; AK008648; BAB25806.1; -; mRNA.
DR CCDS; CCDS37135.1; -.
DR RefSeq; NP_079898.2; NM_025622.3.
DR AlphaFoldDB; Q9CQW5; -.
DR SMR; Q9CQW5; -.
DR ComplexPortal; CPX-96; Galectin-2 complex.
DR IntAct; Q9CQW5; 3.
DR STRING; 10090.ENSMUSP00000036598; -.
DR PhosphoSitePlus; Q9CQW5; -.
DR MaxQB; Q9CQW5; -.
DR PaxDb; Q9CQW5; -.
DR PeptideAtlas; Q9CQW5; -.
DR PRIDE; Q9CQW5; -.
DR ProteomicsDB; 264933; -.
DR Antibodypedia; 286; 317 antibodies from 31 providers.
DR DNASU; 107753; -.
DR Ensembl; ENSMUST00000044584; ENSMUSP00000036598; ENSMUSG00000043501.
DR GeneID; 107753; -.
DR KEGG; mmu:107753; -.
DR UCSC; uc007wrm.2; mouse.
DR CTD; 3957; -.
DR MGI; MGI:895068; Lgals2.
DR VEuPathDB; HostDB:ENSMUSG00000043501; -.
DR eggNOG; KOG3587; Eukaryota.
DR GeneTree; ENSGT00940000155025; -.
DR HOGENOM; CLU_037794_5_0_1; -.
DR InParanoid; Q9CQW5; -.
DR OMA; WQSEHRD; -.
DR OrthoDB; 1429018at2759; -.
DR PhylomeDB; Q9CQW5; -.
DR TreeFam; TF315551; -.
DR BioGRID-ORCS; 107753; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Lgals2; mouse.
DR PRO; PR:Q9CQW5; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9CQW5; protein.
DR Bgee; ENSMUSG00000043501; Expressed in mucosa of stomach and 102 other tissues.
DR Genevisible; Q9CQW5; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:1990724; C:galectin complex; ISO:MGI.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0016936; F:galactoside binding; ISO:MGI.
DR GO; GO:0098609; P:cell-cell adhesion; ISO:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IDA:ComplexPortal.
DR GO; GO:0043029; P:T cell homeostasis; ISO:MGI.
DR CDD; cd00070; GLECT; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR044156; Galectin-like.
DR InterPro; IPR001079; Galectin_CRD.
DR PANTHER; PTHR11346; PTHR11346; 1.
DR Pfam; PF00337; Gal-bind_lectin; 1.
DR SMART; SM00908; Gal-bind_lectin; 1.
DR SMART; SM00276; GLECT; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS51304; GALECTIN; 1.
PE 1: Evidence at protein level;
KW Lectin; Reference proteome.
FT CHAIN 1..130
FT /note="Galectin-2"
FT /id="PRO_0000076925"
FT DOMAIN 4..130
FT /note="Galectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT BINDING 65..71
FT /ligand="a beta-D-galactoside"
FT /ligand_id="ChEBI:CHEBI:28034"
FT /evidence="ECO:0000255"
FT CONFLICT 36
FT /note="G -> V (in Ref. 1; BAB25806)"
FT /evidence="ECO:0000305"
FT CONFLICT 106
FT /note="P -> R (in Ref. 1; BAB25661)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 14880 MW; 4E5EA89F3E0C36FD CRC64;
MSEKFEVKDL NMKPGMSLKI KGKIHNDVDR FLINLGQGKE TLNLHFNPRF DESTIVCNTS
EGGRWGQEQR ENHMCFSPGS EVKITITFQD KDFKVTLPDG HQLTFPNRLG HNQLHYLSMG
GLQISSFKLE
