ID   LEG2_RAT                Reviewed;         130 AA.
AC   Q9Z144;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Galectin-2;
DE            Short=Gal-2;
GN   Name=Lgals2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9882446; DOI=10.1006/abbi.1998.0968;
RA   Oka T., Murakami S., Arata Y., Hirabayashi J., Kasai K., Wada Y., Futai M.;
RT   "Identification and cloning of rat galectin-2: expression is predominantly
RT   in epithelial cells of the stomach.";
RL   Arch. Biochem. Biophys. 361:195-201(1999).
CC   -!- FUNCTION: This protein binds beta-galactoside. Its physiological
CC       function is not yet known.
CC   -!- SUBUNIT: Homodimer.
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DR   EMBL; AB001075; BAA74954.1; -; mRNA.
DR   RefSeq; NP_598283.1; NM_133599.1.
DR   AlphaFoldDB; Q9Z144; -.
DR   SMR; Q9Z144; -.
DR   IntAct; Q9Z144; 2.
DR   STRING; 10116.ENSRNOP00000011750; -.
DR   iPTMnet; Q9Z144; -.
DR   PhosphoSitePlus; Q9Z144; -.
DR   PaxDb; Q9Z144; -.
DR   PRIDE; Q9Z144; -.
DR   GeneID; 171134; -.
DR   KEGG; rno:171134; -.
DR   UCSC; RGD:621269; rat.
DR   CTD; 3957; -.
DR   RGD; 621269; Lgals2.
DR   VEuPathDB; HostDB:ENSRNOG00000008539; -.
DR   eggNOG; KOG3587; Eukaryota.
DR   HOGENOM; CLU_037794_5_0_1; -.
DR   InParanoid; Q9Z144; -.
DR   OMA; WQSEHRD; -.
DR   OrthoDB; 1429018at2759; -.
DR   PhylomeDB; Q9Z144; -.
DR   TreeFam; TF315551; -.
DR   PRO; PR:Q9Z144; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000008539; Expressed in jejunum and 13 other tissues.
DR   Genevisible; Q9Z144; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:1990724; C:galectin complex; ISO:RGD.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0016936; F:galactoside binding; IDA:RGD.
DR   GO; GO:0098609; P:cell-cell adhesion; ISO:RGD.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; ISO:RGD.
DR   GO; GO:0043029; P:T cell homeostasis; ISO:RGD.
DR   CDD; cd00070; GLECT; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR001079; Galectin_CRD.
DR   PANTHER; PTHR11346; PTHR11346; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SMART; SM00908; Gal-bind_lectin; 1.
DR   SMART; SM00276; GLECT; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   2: Evidence at transcript level;
KW   Lectin; Reference proteome.
FT   CHAIN           1..130
FT                   /note="Galectin-2"
FT                   /id="PRO_0000076927"
FT   DOMAIN          4..130
FT                   /note="Galectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   BINDING         65..71
FT                   /ligand="a beta-D-galactoside"
FT                   /ligand_id="ChEBI:CHEBI:28034"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   130 AA;  14733 MW;  E4641D804C9CA7E0 CRC64;
     MSEKFEVTNL NMKSGMSLKI KGKIHNDVNS FTINLGQGKE TLNLHFNPRF NESTIVCNTL
     DGSSWGQEQR ENHSCFSPGS EVKLTLTFQD KDFKVTLPDG HSLTFPNRLG HNHLRYLSMD
     GLQISSFKLE