ID   LEG4_BOVIN              Reviewed;         332 AA.
AC   Q3T0D6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Galectin-4;
DE            Short=Gal-4;
GN   Name=LGALS4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Galectin that binds lactose and a related range of sugars.
CC       May be involved in the assembly of adherens junctions (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- DOMAIN: Contains two homologous but distinct carbohydrate-binding
CC       domains. {ECO:0000250}.
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DR   EMBL; BC102444; AAI02445.1; -; mRNA.
DR   RefSeq; NP_001029940.1; NM_001034768.2.
DR   AlphaFoldDB; Q3T0D6; -.
DR   SMR; Q3T0D6; -.
DR   STRING; 9913.ENSBTAP00000021701; -.
DR   PaxDb; Q3T0D6; -.
DR   PeptideAtlas; Q3T0D6; -.
DR   PRIDE; Q3T0D6; -.
DR   GeneID; 614804; -.
DR   KEGG; bta:614804; -.
DR   CTD; 3960; -.
DR   eggNOG; KOG3587; Eukaryota.
DR   InParanoid; Q3T0D6; -.
DR   OrthoDB; 829777at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   CDD; cd00070; GLECT; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR015533; Galectin4/6.
DR   InterPro; IPR001079; Galectin_CRD.
DR   PANTHER; PTHR11346; PTHR11346; 1.
DR   PANTHER; PTHR11346:SF32; PTHR11346:SF32; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 2.
DR   SMART; SM00908; Gal-bind_lectin; 2.
DR   SMART; SM00276; GLECT; 2.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS51304; GALECTIN; 2.
PE   2: Evidence at transcript level;
KW   Lectin; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..332
FT                   /note="Galectin-4"
FT                   /id="PRO_0000283724"
FT   DOMAIN          19..150
FT                   /note="Galectin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   DOMAIN          203..332
FT                   /note="Galectin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   BINDING         265..271
FT                   /ligand="a beta-D-galactoside"
FT                   /ligand_id="ChEBI:CHEBI:28034"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         267
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P38552"
SQ   SEQUENCE   332 AA;  37171 MW;  C40AF61EC5FE28B0 CRC64;
     MAFVPAPGYQ PTYNPTLPYH NPIPGGLRVG MSVYIQGVAS EHMKRFFVNF EVGQGQGADV
     AFHFNPRFDG WDKVVLNSKQ NGSWGQEERK MSMPFRKGAA FELVFMVMTE HFKVVVNGTP
     FHEFKHRIPL QMVTHLHVDG DLMLQSINFI GGQPPSNQMP MPAQAYPMPM SAQAYPSPGQ
     YYQQQSRLPT MEGPPAFNPP VPFNGRLQGG LIVRRTIIIK GYIPPTAKSF VINFKVGSSG
     DVALHINPRM TEGAVVRNSF LNGSWGSEER KVSYNPFGPG QFFDLSVRCG ADRFKVYANG
     KHLFDFSHRL SAFQRVDLVE IHGDVTLSYV QI