LEG4_PIG
ID LEG4_PIG Reviewed; 323 AA.
AC Q29058; Q29296;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Galectin-4;
DE Short=Gal-4;
DE AltName: Full=L-36 lactose-binding protein;
DE Short=L36LBP;
DE AltName: Full=Lactose-binding lectin 4;
GN Name=LGALS4;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Tongue;
RX PubMed=7989350; DOI=10.1016/s0021-9258(18)31762-9;
RA Chiu M.L., Parry D.A.D., Feldman S.R., Klapper D.G., O'Keefe E.J.;
RT "An adherens junction protein is a member of the family of lactose-binding
RT lectins.";
RL J. Biol. Chem. 269:31770-31776(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-140.
RC TISSUE=Small intestine;
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
CC -!- FUNCTION: Galectin that binds lactose and a related range of sugars.
CC May be involved in the assembly of adherens junctions.
CC -!- SUBUNIT: Monomer.
CC -!- DOMAIN: Contains two homologous but distinct carbohydrate-binding
CC domains.
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DR EMBL; X79303; CAA55884.1; -; mRNA.
DR EMBL; F14653; CAA23179.1; -; mRNA.
DR PIR; A55664; A55664.
DR RefSeq; NP_999146.1; NM_213981.1.
DR AlphaFoldDB; Q29058; -.
DR SMR; Q29058; -.
DR PeptideAtlas; Q29058; -.
DR PRIDE; Q29058; -.
DR GeneID; 397041; -.
DR KEGG; ssc:397041; -.
DR CTD; 3960; -.
DR InParanoid; Q29058; -.
DR OrthoDB; 829777at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR CDD; cd00070; GLECT; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR044156; Galectin-like.
DR InterPro; IPR015533; Galectin4/6.
DR InterPro; IPR001079; Galectin_CRD.
DR PANTHER; PTHR11346; PTHR11346; 1.
DR PANTHER; PTHR11346:SF32; PTHR11346:SF32; 1.
DR Pfam; PF00337; Gal-bind_lectin; 2.
DR SMART; SM00908; Gal-bind_lectin; 2.
DR SMART; SM00276; GLECT; 2.
DR SUPFAM; SSF49899; SSF49899; 2.
DR PROSITE; PS51304; GALECTIN; 2.
PE 2: Evidence at transcript level;
KW Lectin; Reference proteome; Repeat.
FT CHAIN 1..323
FT /note="Galectin-4"
FT /id="PRO_0000076936"
FT DOMAIN 19..150
FT /note="Galectin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT DOMAIN 194..323
FT /note="Galectin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT BINDING 256..262
FT /ligand="a beta-D-galactoside"
FT /ligand_id="ChEBI:CHEBI:28034"
FT /evidence="ECO:0000250"
FT CONFLICT 98..99
FT /note="AP -> GA (in Ref. 2; CAA23179)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="H -> T (in Ref. 2; CAA23179)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 323 AA; 35852 MW; 728C761712B29343 CRC64;
MAFVPAPGYQ PTYNPTLPYY KPIPGGLRVG MSVYIQGVAN EHMKRFFVNF VVGQGPGADV
AFHFNPRFDG WDKVVFNSQQ DGKWGNEEKK RSMPFRKAPA FELVIMVLPE HYKVVVNGDP
FYEFGHRIPV QLVTHLQVDG DLTLQSINFI GGQPAPSPGP MPNPGYPGPG KHNQQPCNLP
CMEGAPTFNP PVPYKTRLQG GLVARRTIVI KGYVPPSGKS LVINFKVGSS GDVALHINPR
LTEGIVVRNS YLNGKWGAEE RKSSFNPFAP GQYFDLSIRC GLDRFKVYAN GQHLFDFSHR
LSNFQGVDTL EIQGDVTLSY VQI
