ID   LEG5_RAT                Reviewed;         145 AA.
AC   P47967;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Galectin-5;
DE            Short=Gal-5;
DE   AltName: Full=RL-18;
GN   Name=Lgals5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CLEAVAGE OF INITIATOR
RP   METHIONINE, AND ACETYLATION AT SER-2.
RC   TISSUE=Reticulocyte;
RX   PubMed=7890611; DOI=10.1074/jbc.270.10.5032;
RA   Gitt M.A., Wiser M.F., Leffler H., Herrmann J., Xia Y.-R., Massa S.M.,
RA   Cooper D.N.W., Lusis A.J., Barondes S.H.;
RT   "Sequence and mapping of galectin-5, a beta-galactoside-binding lectin,
RT   found in rat erythrocytes.";
RL   J. Biol. Chem. 270:5032-5038(1995).
CC   -!- FUNCTION: May function in erythrocyte differentiation.
CC   -!- SUBUNIT: Monomer.
CC   -!- TISSUE SPECIFICITY: Erythrocytes.
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DR   EMBL; L36862; AAC42050.1; -; mRNA.
DR   EMBL; L21711; AAA65445.1; -; mRNA.
DR   PIR; A55932; A55932.
DR   RefSeq; NP_037108.1; NM_012976.2.
DR   PDB; 5JP5; X-ray; 1.70 A; A/B/C/D/E/F=1-145.
DR   PDB; 5JPG; X-ray; 1.90 A; A/B=1-145.
DR   PDBsum; 5JP5; -.
DR   PDBsum; 5JPG; -.
DR   AlphaFoldDB; P47967; -.
DR   SMR; P47967; -.
DR   STRING; 10116.ENSRNOP00000016897; -.
DR   UniLectin; P47967; -.
DR   iPTMnet; P47967; -.
DR   PhosphoSitePlus; P47967; -.
DR   PRIDE; P47967; -.
DR   GeneID; 25475; -.
DR   KEGG; rno:25475; -.
DR   CTD; 25475; -.
DR   RGD; 3004; Lgals5.
DR   eggNOG; KOG3587; Eukaryota.
DR   InParanoid; P47967; -.
DR   OrthoDB; 829777at2759; -.
DR   PhylomeDB; P47967; -.
DR   PRO; PR:P47967; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR   GO; GO:0016936; F:galactoside binding; IBA:GO_Central.
DR   GO; GO:0030395; F:lactose binding; ISO:RGD.
DR   GO; GO:2000562; P:negative regulation of CD4-positive, alpha-beta T cell proliferation; IBA:GO_Central.
DR   GO; GO:0032689; P:negative regulation of interferon-gamma production; IBA:GO_Central.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0070234; P:positive regulation of T cell apoptotic process; ISO:RGD.
DR   CDD; cd00070; GLECT; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR001079; Galectin_CRD.
DR   PANTHER; PTHR11346; PTHR11346; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SMART; SM00908; Gal-bind_lectin; 1.
DR   SMART; SM00276; GLECT; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Direct protein sequencing; Lectin;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:7890611"
FT   CHAIN           2..145
FT                   /note="Galectin-5"
FT                   /id="PRO_0000076938"
FT   DOMAIN          17..145
FT                   /note="Galectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   BINDING         77..83
FT                   /ligand="a beta-D-galactoside"
FT                   /ligand_id="ChEBI:CHEBI:28034"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|PubMed:7890611"
FT   CONFLICT        128..136
FT                   /note="Missing (in Ref. 1; AAA65445)"
FT                   /evidence="ECO:0000305"
FT   STRAND          3..10
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   STRAND          15..20
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   STRAND          30..37
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   STRAND          43..50
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   STRAND          53..61
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   TURN            62..65
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   STRAND          66..73
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   STRAND          85..87
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   STRAND          95..102
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   STRAND          104..111
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   STRAND          114..120
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   HELIX           126..128
FT                   /evidence="ECO:0007829|PDB:5JP5"
FT   STRAND          131..144
FT                   /evidence="ECO:0007829|PDB:5JP5"
SQ   SEQUENCE   145 AA;  16196 MW;  A6F0FB8C460DDBA4 CRC64;
     MSSFSTQTPY PNLAVPFFTS IPNGLYPSKS IVISGVVLSD AKRFQINLRC GGDIAFHLNP
     RFDENAVVRN TQINNSWGPE ERSLPGSMPF SRGQRFSVWI LCEGHCFKVA VDGQHICEYS
     HRLMNLPDIN TLEVAGDIQL THVET