LEG7_MOUSE
ID LEG7_MOUSE Reviewed; 136 AA.
AC O54974;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Galectin-7;
DE Short=Gal-7;
GN Name=Lgals7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=9697310; DOI=10.1046/j.1432-0436.1998.6330159.x;
RA Magnaldo T., Fowlis D., Darmon M.;
RT "Galectin-7, a marker of all types of stratified epithelia.";
RL Differentiation 63:159-168(1998).
CC -!- FUNCTION: Could be involved in cell-cell and/or cell-matrix
CC interactions necessary for normal growth control. Pro-apoptotic protein
CC that functions intracellularly upstream of JNK activation and
CC cytochrome c release (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Secreted {ECO:0000250}. Note=May be secreted by a non-classical
CC secretory pathway. {ECO:0000250}.
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DR EMBL; AF038562; AAB92566.1; -; mRNA.
DR AlphaFoldDB; O54974; -.
DR SMR; O54974; -.
DR STRING; 10090.ENSMUSP00000080179; -.
DR BindingDB; O54974; -.
DR ChEMBL; CHEMBL4523143; -.
DR PhosphoSitePlus; O54974; -.
DR MaxQB; O54974; -.
DR PeptideAtlas; O54974; -.
DR PRIDE; O54974; -.
DR ProteomicsDB; 252465; -.
DR MGI; MGI:1316742; Lgals7.
DR eggNOG; KOG3587; Eukaryota.
DR InParanoid; O54974; -.
DR PhylomeDB; O54974; -.
DR ChiTaRS; Lgals7; mouse.
DR PRO; PR:O54974; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O54974; protein.
DR GO; GO:0001533; C:cornified envelope; IDA:MGI.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR GO; GO:0016936; F:galactoside binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:InterPro.
DR GO; GO:2000562; P:negative regulation of CD4-positive, alpha-beta T cell proliferation; IBA:GO_Central.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR CDD; cd00070; GLECT; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR044156; Galectin-like.
DR InterPro; IPR030640; Galectin_7.
DR InterPro; IPR001079; Galectin_CRD.
DR PANTHER; PTHR11346; PTHR11346; 1.
DR PANTHER; PTHR11346:SF107; PTHR11346:SF107; 1.
DR Pfam; PF00337; Gal-bind_lectin; 1.
DR SMART; SM00908; Gal-bind_lectin; 1.
DR SMART; SM00276; GLECT; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS51304; GALECTIN; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytoplasm; Lectin; Nucleus; Reference proteome; Secreted.
FT CHAIN 1..136
FT /note="Galectin-7"
FT /id="PRO_0000076941"
FT DOMAIN 6..136
FT /note="Galectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT BINDING 70..76
FT /ligand="a beta-D-galactoside"
FT /ligand_id="ChEBI:CHEBI:28034"
FT /evidence="ECO:0000255"
SQ SEQUENCE 136 AA; 15173 MW; 24E105BBF333692A CRC64;
MSATHHKTSL PQGVRVGTVM RIRGLVPDQA GRFHVNLLCG EEQGADAALH FNPRLDTSEV
VFNTKQQGKW GREERGTGIP FQRGQPFEVL LIATEEGFKA VVGDDEYLHF HHRLPPARVR
LVEVGGDVQL HSLNIF
