LEG9B_HUMAN
ID LEG9B_HUMAN Reviewed; 356 AA.
AC Q3B8N2; A6NLF8; A8K2J8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 3.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Galectin-9B;
DE Short=Gal-9B;
DE AltName: Full=Galectin-9-like protein A;
GN Name=LGALS9B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-356 (ISOFORM 2).
RC TISSUE=Stomach;
RA Kim N.S., Hahn Y., Oh J.H., Lee J.Y., Ahn H.Y., Chu M.Y., Kim M.R.,
RA Oh K.J., Cheong J.E., Sohn H.Y., Kim J.M., Park H.S., Kim S., Kim Y.S.;
RT "21C frontier Korean EST project 2001.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds galactosides. {ECO:0000250}.
CC -!- INTERACTION:
CC Q3B8N2; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-10240775, EBI-11096309;
CC Q3B8N2; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-10240775, EBI-1166928;
CC Q3B8N2; O75553: DAB1; NbExp=3; IntAct=EBI-10240775, EBI-7875264;
CC Q3B8N2; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-10240775, EBI-2341787;
CC Q3B8N2; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10240775, EBI-741158;
CC Q3B8N2; Q9NRG1: PRTFDC1; NbExp=3; IntAct=EBI-10240775, EBI-739759;
CC Q3B8N2; P47897: QARS1; NbExp=3; IntAct=EBI-10240775, EBI-347462;
CC Q3B8N2; O00308: WWP2; NbExp=5; IntAct=EBI-10240775, EBI-743923;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3B8N2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3B8N2-2; Sequence=VSP_035176;
CC -!- MISCELLANEOUS: The LGALS9-like proteins are encoded by a duplicated
CC regions on chromosome 17; there are at least 3 genes coding for
CC galectin-9-like proteins.
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DR EMBL; AK290263; BAF82952.1; -; mRNA.
DR EMBL; AC015818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC087499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC105943; AAI05944.1; -; mRNA.
DR EMBL; BM769345; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BM769737; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS42283.1; -. [Q3B8N2-2]
DR RefSeq; NP_001036150.1; NM_001042685.1. [Q3B8N2-2]
DR AlphaFoldDB; Q3B8N2; -.
DR SMR; Q3B8N2; -.
DR BioGRID; 129785; 50.
DR IntAct; Q3B8N2; 12.
DR STRING; 9606.ENSP00000315564; -.
DR iPTMnet; Q3B8N2; -.
DR PhosphoSitePlus; Q3B8N2; -.
DR BioMuta; LGALS9B; -.
DR DMDM; 205371780; -.
DR jPOST; Q3B8N2; -.
DR MassIVE; Q3B8N2; -.
DR MaxQB; Q3B8N2; -.
DR PaxDb; Q3B8N2; -.
DR PeptideAtlas; Q3B8N2; -.
DR PRIDE; Q3B8N2; -.
DR ProteomicsDB; 61670; -. [Q3B8N2-1]
DR ProteomicsDB; 61671; -. [Q3B8N2-2]
DR Antibodypedia; 55103; 92 antibodies from 15 providers.
DR DNASU; 284194; -.
DR Ensembl; ENST00000324290.5; ENSP00000315564.5; ENSG00000170298.16. [Q3B8N2-2]
DR Ensembl; ENST00000423676.8; ENSP00000388841.3; ENSG00000170298.16. [Q3B8N2-1]
DR GeneID; 284194; -.
DR KEGG; hsa:284194; -.
DR MANE-Select; ENST00000423676.8; ENSP00000388841.3; NM_001367292.2; NP_001354221.1.
DR UCSC; uc002gwz.1; human. [Q3B8N2-1]
DR CTD; 284194; -.
DR GeneCards; LGALS9B; -.
DR HGNC; HGNC:24842; LGALS9B.
DR HPA; ENSG00000170298; Tissue enhanced (esophagus, intestine, stomach).
DR neXtProt; NX_Q3B8N2; -.
DR OpenTargets; ENSG00000170298; -.
DR PharmGKB; PA162393903; -.
DR VEuPathDB; HostDB:ENSG00000170298; -.
DR eggNOG; KOG3587; Eukaryota.
DR GeneTree; ENSGT00940000162701; -.
DR HOGENOM; CLU_037794_1_0_1; -.
DR InParanoid; Q3B8N2; -.
DR OMA; QEKFEPG; -.
DR OrthoDB; 829777at2759; -.
DR PhylomeDB; Q3B8N2; -.
DR TreeFam; TF315551; -.
DR PathwayCommons; Q3B8N2; -.
DR SignaLink; Q3B8N2; -.
DR BioGRID-ORCS; 284194; 58 hits in 634 CRISPR screens.
DR ChiTaRS; LGALS9B; human.
DR GenomeRNAi; 284194; -.
DR Pharos; Q3B8N2; Tdark.
DR PRO; PR:Q3B8N2; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q3B8N2; protein.
DR Bgee; ENSG00000170298; Expressed in mucosa of transverse colon and 85 other tissues.
DR ExpressionAtlas; Q3B8N2; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR GO; GO:0016936; F:galactoside binding; IBA:GO_Central.
DR GO; GO:2000562; P:negative regulation of CD4-positive, alpha-beta T cell proliferation; IBA:GO_Central.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR CDD; cd00070; GLECT; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR044156; Galectin-like.
DR InterPro; IPR001079; Galectin_CRD.
DR PANTHER; PTHR11346; PTHR11346; 1.
DR Pfam; PF00337; Gal-bind_lectin; 2.
DR SMART; SM00908; Gal-bind_lectin; 2.
DR SMART; SM00276; GLECT; 2.
DR SUPFAM; SSF49899; SSF49899; 2.
DR PROSITE; PS51304; GALECTIN; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Lectin; Reference proteome; Repeat.
FT CHAIN 1..356
FT /note="Galectin-9B"
FT /id="PRO_0000321949"
FT DOMAIN 17..148
FT /note="Galectin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT DOMAIN 228..356
FT /note="Galectin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT REGION 170..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 82..88
FT /ligand="a beta-D-galactoside"
FT /ligand_id="ChEBI:CHEBI:28034"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 288..294
FT /ligand="a beta-D-galactoside"
FT /ligand_id="ChEBI:CHEBI:28034"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT VAR_SEQ 210
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_035176"
FT CONFLICT 6
FT /note="S -> C (in Ref. 1; BAF82952)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="T -> A (in Ref. 3; AAI05944)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="R -> Q (in Ref. 1; BAF82952)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 356 AA; 39660 MW; BD0FB91708EA5A4A CRC64;
MAFSGSQAPY LSPAVPFSGT IQGGLQDGFQ ITVNGAVLSS SGTRFAVDFQ TGFSGNDIAF
HFNPRFEDGG YVVCNTRQKG RWGPEERKMH MPFQKGMPFD LCFLVQSSDF KVMVNGSLFV
QYFHRVPFHR VDTISVNGSV QLSYISFQNP RTVPVQPAFS TVPFSQPVCF PPRPRGRRQK
PPSVRPANPA PITQTVIHTV QSASGQMFSQ TPAIPPMMYP HPAYPMPFIT TIPGGLYPSK
SIILSGTVLP SAQRFHINLC SGSHIAFHMN PRFDENAVVR NTQINNSWGS EERSLPRKMP
FVRGQSFSVW ILCEAHCLKV AVDGQHVFEY YHRLRNLPTI NKLEVGGDIQ LTHVQT
