LEG9C_HUMAN
ID LEG9C_HUMAN Reviewed; 356 AA.
AC Q6DKI2; B0AZM7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Galectin-9C;
DE Short=Gal-9C;
DE AltName: Full=Galectin-9-like protein B;
GN Name=LGALS9C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-126.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds galactosides. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6DKI2; Q86V38: ATN1; NbExp=3; IntAct=EBI-9088829, EBI-11954292;
CC Q6DKI2; P54253: ATXN1; NbExp=6; IntAct=EBI-9088829, EBI-930964;
CC Q6DKI2; Q9Y5Z0: BACE2; NbExp=3; IntAct=EBI-9088829, EBI-11282723;
CC Q6DKI2; P46379-2: BAG6; NbExp=3; IntAct=EBI-9088829, EBI-10988864;
CC Q6DKI2; P55212: CASP6; NbExp=3; IntAct=EBI-9088829, EBI-718729;
CC Q6DKI2; P06307: CCK; NbExp=3; IntAct=EBI-9088829, EBI-6624398;
CC Q6DKI2; P02489: CRYAA; NbExp=3; IntAct=EBI-9088829, EBI-6875961;
CC Q6DKI2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-9088829, EBI-3867333;
CC Q6DKI2; O75553: DAB1; NbExp=3; IntAct=EBI-9088829, EBI-7875264;
CC Q6DKI2; O14645: DNALI1; NbExp=3; IntAct=EBI-9088829, EBI-395638;
CC Q6DKI2; P50570-2: DNM2; NbExp=3; IntAct=EBI-9088829, EBI-10968534;
CC Q6DKI2; Q14204: DYNC1H1; NbExp=3; IntAct=EBI-9088829, EBI-356015;
CC Q6DKI2; P00488: F13A1; NbExp=3; IntAct=EBI-9088829, EBI-2565863;
CC Q6DKI2; P14136: GFAP; NbExp=3; IntAct=EBI-9088829, EBI-744302;
CC Q6DKI2; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-9088829, EBI-1055254;
CC Q6DKI2; O14901: KLF11; NbExp=3; IntAct=EBI-9088829, EBI-948266;
CC Q6DKI2; Q92876: KLK6; NbExp=3; IntAct=EBI-9088829, EBI-2432309;
CC Q6DKI2; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-9088829, EBI-11962084;
CC Q6DKI2; P13473-2: LAMP2; NbExp=3; IntAct=EBI-9088829, EBI-21591415;
CC Q6DKI2; P19404: NDUFV2; NbExp=3; IntAct=EBI-9088829, EBI-713665;
CC Q6DKI2; P29474: NOS3; NbExp=3; IntAct=EBI-9088829, EBI-1391623;
CC Q6DKI2; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-9088829, EBI-2811583;
CC Q6DKI2; O15162: PLSCR1; NbExp=3; IntAct=EBI-9088829, EBI-740019;
CC Q6DKI2; D3DTS7: PMP22; NbExp=3; IntAct=EBI-9088829, EBI-25882629;
CC Q6DKI2; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-9088829, EBI-5280197;
CC Q6DKI2; P47897: QARS1; NbExp=3; IntAct=EBI-9088829, EBI-347462;
CC Q6DKI2; Q93062: RBPMS; NbExp=3; IntAct=EBI-9088829, EBI-740322;
CC Q6DKI2; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-9088829, EBI-2623095;
CC Q6DKI2; Q13148: TARDBP; NbExp=6; IntAct=EBI-9088829, EBI-372899;
CC -!- MISCELLANEOUS: The LGALS9-like proteins are encoded by a duplicated
CC regions on chromosome 17; there are at least 3 genes coding for
CC galectin-9-like proteins.
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DR EMBL; AK315818; BAF98709.1; -; mRNA.
DR EMBL; AC107983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC073889; AAH73889.1; -; mRNA.
DR CCDS; CCDS32587.1; -.
DR RefSeq; NP_001035167.2; NM_001040078.2.
DR AlphaFoldDB; Q6DKI2; -.
DR SMR; Q6DKI2; -.
DR BioGRID; 576335; 35.
DR IntAct; Q6DKI2; 51.
DR STRING; 9606.ENSP00000329932; -.
DR iPTMnet; Q6DKI2; -.
DR PhosphoSitePlus; Q6DKI2; -.
DR BioMuta; LGALS9C; -.
DR DMDM; 296434563; -.
DR jPOST; Q6DKI2; -.
DR MassIVE; Q6DKI2; -.
DR MaxQB; Q6DKI2; -.
DR PaxDb; Q6DKI2; -.
DR PeptideAtlas; Q6DKI2; -.
DR PRIDE; Q6DKI2; -.
DR ProteomicsDB; 66231; -.
DR Antibodypedia; 67999; 81 antibodies from 14 providers.
DR DNASU; 654346; -.
DR Ensembl; ENST00000328114.11; ENSP00000329932.6; ENSG00000171916.17.
DR Ensembl; ENST00000639265.2; ENSP00000491587.1; ENSG00000284021.2.
DR GeneID; 654346; -.
DR KEGG; hsa:654346; -.
DR MANE-Select; ENST00000328114.11; ENSP00000329932.6; NM_001040078.3; NP_001035167.2.
DR UCSC; uc002gtw.4; human.
DR CTD; 654346; -.
DR DisGeNET; 654346; -.
DR GeneCards; LGALS9C; -.
DR HGNC; HGNC:33874; LGALS9C.
DR HPA; ENSG00000171916; Tissue enhanced (esophagus, intestine, stomach).
DR neXtProt; NX_Q6DKI2; -.
DR OpenTargets; ENSG00000171916; -.
DR PharmGKB; PA162393930; -.
DR VEuPathDB; HostDB:ENSG00000171916; -.
DR eggNOG; KOG3587; Eukaryota.
DR GeneTree; ENSGT00940000162701; -.
DR InParanoid; Q6DKI2; -.
DR OMA; FLCFNND; -.
DR OrthoDB; 829777at2759; -.
DR PhylomeDB; Q6DKI2; -.
DR TreeFam; TF315551; -.
DR PathwayCommons; Q6DKI2; -.
DR SignaLink; Q6DKI2; -.
DR BioGRID-ORCS; 654346; 114 hits in 987 CRISPR screens.
DR GenomeRNAi; 654346; -.
DR Pharos; Q6DKI2; Tdark.
DR PRO; PR:Q6DKI2; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6DKI2; protein.
DR Bgee; ENSG00000171916; Expressed in rectum and 85 other tissues.
DR ExpressionAtlas; Q6DKI2; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR GO; GO:0016936; F:galactoside binding; IBA:GO_Central.
DR GO; GO:2000562; P:negative regulation of CD4-positive, alpha-beta T cell proliferation; IBA:GO_Central.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR CDD; cd00070; GLECT; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR044156; Galectin-like.
DR InterPro; IPR001079; Galectin_CRD.
DR PANTHER; PTHR11346; PTHR11346; 1.
DR Pfam; PF00337; Gal-bind_lectin; 2.
DR SMART; SM00908; Gal-bind_lectin; 2.
DR SMART; SM00276; GLECT; 2.
DR SUPFAM; SSF49899; SSF49899; 2.
DR PROSITE; PS51304; GALECTIN; 2.
PE 1: Evidence at protein level;
KW Lectin; Reference proteome; Repeat.
FT CHAIN 1..356
FT /note="Galectin-9C"
FT /id="PRO_0000332131"
FT DOMAIN 17..148
FT /note="Galectin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT DOMAIN 228..356
FT /note="Galectin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT REGION 170..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 82..88
FT /ligand="a beta-D-galactoside"
FT /ligand_id="ChEBI:CHEBI:28034"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 288..294
FT /ligand="a beta-D-galactoside"
FT /ligand_id="ChEBI:CHEBI:28034"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT VARIANT 126
FT /note="V -> M (in dbSNP:rs3907319)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_056004"
FT CONFLICT 81
FT /note="T -> R (in Ref. 1; BAF98709)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="V -> A (in Ref. 1; BAF98709)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="S -> I (in Ref. 3; AAH73889)"
FT /evidence="ECO:0000305"
FT CONFLICT 306
FT /note="S -> C (in Ref. 1; BAF98709)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 356 AA; 39607 MW; 539BAFD9FD53EE19 CRC64;
MAFSGCQAPY LSPAVPFSGT IQGGLQDGFQ ITVNGAVLSC SGTRFAVDFQ TGFSGNDIAF
HFNPRFEDGG YVVCNTRQKG TWGPEERKMH MPFQKGMPFD LCFLVQSSDF KVMVNGSLFV
QYFHRVPFHR VDTISVNGSV QLSYISFQNP RAVPVQPAFS TVPFSQPVCF PPRPRGRRQK
PPSVRPANPA PITQTVIHTV QSASGQMFSQ TPAIPPMMYP HPAYPMPFIT TIPGGLYPSK
SIILSGTVLP SAQRFHINLC SGSHIAFHMN PRFDENAVVR NTQINNSWGS EERSLPRKMP
FVRGQSFSVW ILCEAHCLKV AVDGQHVFEY YHRLRNLPTI NKLEVGGDIQ LTHVQT
