ID   LEGL_CHICK              Reviewed;         171 AA.
AC   Q5ZHQ2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Galectin-related protein;
DE   AltName: Full=Lectin galactoside-binding-like protein;
GN   Name=LGALSL; Synonyms=GRP; ORFNames=RCJMB04_34j3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Does not bind lactose, and may not bind carbohydrates.
CC       {ECO:0000250}.
CC   -!- CAUTION: Most of the residues in the galectin domain that have been
CC       shown to be critical for carbohydrate-binding in other galectins are
CC       not conserved. {ECO:0000305}.
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DR   EMBL; AJ721082; CAG32741.1; -; mRNA.
DR   RefSeq; NP_001008456.1; NM_001008456.1.
DR   PDB; 5IT6; X-ray; 1.55 A; A=38-171.
DR   PDBsum; 5IT6; -.
DR   AlphaFoldDB; Q5ZHQ2; -.
DR   SMR; Q5ZHQ2; -.
DR   STRING; 9031.ENSGALP00000043097; -.
DR   PaxDb; Q5ZHQ2; -.
DR   Ensembl; ENSGALT00000044527; ENSGALP00000043097; ENSGALG00000027096.
DR   GeneID; 421278; -.
DR   KEGG; gga:421278; -.
DR   CTD; 29094; -.
DR   VEuPathDB; HostDB:geneid_421278; -.
DR   eggNOG; KOG3587; Eukaryota.
DR   GeneTree; ENSGT00940000155337; -.
DR   HOGENOM; CLU_037794_2_1_1; -.
DR   InParanoid; Q5ZHQ2; -.
DR   OMA; CISGEKG; -.
DR   OrthoDB; 829777at2759; -.
DR   PhylomeDB; Q5ZHQ2; -.
DR   TreeFam; TF315551; -.
DR   PRO; PR:Q5ZHQ2; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000027096; Expressed in muscle tissue and 14 other tissues.
DR   ExpressionAtlas; Q5ZHQ2; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   CDD; cd00070; GLECT; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR030651; Galectin-rel.
DR   InterPro; IPR001079; Galectin_CRD.
DR   PANTHER; PTHR11346; PTHR11346; 1.
DR   PANTHER; PTHR11346:SF98; PTHR11346:SF98; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SMART; SM00908; Gal-bind_lectin; 1.
DR   SMART; SM00276; GLECT; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Lectin; Reference proteome.
FT   CHAIN           1..171
FT                   /note="Galectin-related protein"
FT                   /id="PRO_0000315770"
FT   DOMAIN          38..170
FT                   /note="Galectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   STRAND          39..42
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   STRAND          52..59
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   STRAND          65..73
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   TURN            76..79
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   STRAND          82..89
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   TURN            90..93
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   STRAND          94..101
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   STRAND          122..129
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   STRAND          131..138
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   STRAND          141..147
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   HELIX           153..155
FT                   /evidence="ECO:0007829|PDB:5IT6"
FT   STRAND          158..171
FT                   /evidence="ECO:0007829|PDB:5IT6"
SQ   SEQUENCE   171 AA;  19045 MW;  3E55608F82F52DD9 CRC64;
     MAGTVAERDA PKIEDGHLNN SLGSPVQADV YFPRLIVPFC GHIKGGMRPG KKILVMGIVD
     LNPESFGISL TCGESEDPPA DVAIELKAVF TDRQFIRNSC VAGEWGEEQS SIPYFPFIPD
     QPFRVEILCE HPRFRIFVDG HQLFDFYHRI ETLSAIDTIK INGDLQLTKL G