ID   LEGL_PONAB              Reviewed;         172 AA.
AC   Q5R5K6; Q5RD10;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Galectin-related protein;
DE   AltName: Full=Lectin galactoside-binding-like protein;
GN   Name=LGALSL; Synonyms=GRP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Heart, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Does not bind lactose, and may not bind carbohydrates.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5R5K6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5R5K6-2; Sequence=VSP_030697;
CC   -!- CAUTION: Most of the residues in the galectin domain that have been
CC       shown to be critical for carbohydrate-binding in other galectins are
CC       not conserved. {ECO:0000305}.
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DR   EMBL; CR860852; CAH92960.1; -; mRNA.
DR   EMBL; CR858108; CAH90347.1; -; mRNA.
DR   RefSeq; NP_001126745.1; NM_001133273.1. [Q5R5K6-1]
DR   AlphaFoldDB; Q5R5K6; -.
DR   SMR; Q5R5K6; -.
DR   STRING; 9601.ENSPPYP00000013789; -.
DR   Ensembl; ENSPPYT00000014348; ENSPPYP00000013789; ENSPPYG00000012366. [Q5R5K6-1]
DR   Ensembl; ENSPPYT00000036946; ENSPPYP00000031062; ENSPPYG00000012366. [Q5R5K6-2]
DR   GeneID; 100173747; -.
DR   KEGG; pon:100173747; -.
DR   CTD; 29094; -.
DR   eggNOG; KOG3587; Eukaryota.
DR   GeneTree; ENSGT00940000155337; -.
DR   HOGENOM; CLU_037794_2_1_1; -.
DR   InParanoid; Q5R5K6; -.
DR   OMA; CISGEKG; -.
DR   TreeFam; TF315551; -.
DR   Proteomes; UP000001595; Chromosome 2A.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   CDD; cd00070; GLECT; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR030651; Galectin-rel.
DR   InterPro; IPR001079; Galectin_CRD.
DR   PANTHER; PTHR11346; PTHR11346; 1.
DR   PANTHER; PTHR11346:SF98; PTHR11346:SF98; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SMART; SM00908; Gal-bind_lectin; 1.
DR   SMART; SM00276; GLECT; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Lectin; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q3ZCW2"
FT   CHAIN           2..172
FT                   /note="Galectin-related protein"
FT                   /id="PRO_0000315769"
FT   DOMAIN          39..168
FT                   /note="Galectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3ZCW2"
FT   MOD_RES         22
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3ZCW2"
FT   MOD_RES         25
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3ZCW2"
FT   VAR_SEQ         66..172
FT                   /note="SFAISLTCGDSEDPPADVAIELKAVFTDRQLLRNSCISGERGEEQSAIPYFP
FT                   FIPDQPFRVEILCEHPRFRVFVDGHQLFDFYHRIQTLSAIDTIKINGDLQITKLG ->
FT                   RWKFFVSTHVSECLWMDTNFLIFTIAFKRYLQLTP (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_030697"
SQ   SEQUENCE   172 AA;  18986 MW;  E2D41EA68EF44DEC CRC64;
     MAGSVADSDA VVKLDDGHLN NSLSSPVQAD VYFPRLIVPF CGHIKGGMRP GKKVLVMGIV
     DLNPESFAIS LTCGDSEDPP ADVAIELKAV FTDRQLLRNS CISGERGEEQ SAIPYFPFIP
     DQPFRVEILC EHPRFRVFVD GHQLFDFYHR IQTLSAIDTI KINGDLQITK LG