LELP1_HUMAN
ID LELP1_HUMAN Reviewed; 98 AA.
AC Q5T871; A1L4E1;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Late cornified envelope-like proline-rich protein 1;
DE AltName: Full=Novel small proline-rich protein;
GN Name=LELP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5T871; P05187: ALPP; NbExp=3; IntAct=EBI-18115868, EBI-1211484;
CC Q5T871; O95833: CLIC3; NbExp=3; IntAct=EBI-18115868, EBI-10192241;
CC Q5T871; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-18115868, EBI-10172150;
CC Q5T871; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-18115868, EBI-10171774;
CC Q5T871; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-18115868, EBI-10302392;
CC Q5T871; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-18115868, EBI-739863;
CC Q5T871; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-18115868, EBI-11993254;
CC Q5T871; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-18115868, EBI-11993296;
CC Q5T871; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-18115868, EBI-11958178;
CC Q5T871; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-18115868, EBI-11974251;
CC Q5T871; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-18115868, EBI-10250562;
CC Q5T871; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-18115868, EBI-3958099;
CC Q5T871; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-18115868, EBI-1044640;
CC Q5T871; Q92504: SLC39A7; NbExp=3; IntAct=EBI-18115868, EBI-1051105;
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR EMBL; AL161636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC087854; AAH87854.1; -; mRNA.
DR EMBL; BC130507; AAI30508.1; -; mRNA.
DR EMBL; BC130511; AAI30512.1; -; mRNA.
DR CCDS; CCDS30869.1; -.
DR RefSeq; NP_001010857.1; NM_001010857.2.
DR AlphaFoldDB; Q5T871; -.
DR SMR; Q5T871; -.
DR BioGRID; 127185; 15.
DR IntAct; Q5T871; 15.
DR STRING; 9606.ENSP00000357736; -.
DR BioMuta; LELP1; -.
DR DMDM; 74745484; -.
DR MassIVE; Q5T871; -.
DR PaxDb; Q5T871; -.
DR PeptideAtlas; Q5T871; -.
DR PRIDE; Q5T871; -.
DR ProteomicsDB; 64713; -.
DR Antibodypedia; 50369; 94 antibodies from 14 providers.
DR DNASU; 149018; -.
DR Ensembl; ENST00000368747.2; ENSP00000357736.1; ENSG00000203784.3.
DR GeneID; 149018; -.
DR KEGG; hsa:149018; -.
DR MANE-Select; ENST00000368747.2; ENSP00000357736.1; NM_001010857.3; NP_001010857.1.
DR UCSC; uc001fbl.5; human.
DR CTD; 149018; -.
DR DisGeNET; 149018; -.
DR GeneCards; LELP1; -.
DR HGNC; HGNC:32046; LELP1.
DR HPA; ENSG00000203784; Tissue enriched (testis).
DR MIM; 611042; gene.
DR neXtProt; NX_Q5T871; -.
DR OpenTargets; ENSG00000203784; -.
DR PharmGKB; PA142671557; -.
DR VEuPathDB; HostDB:ENSG00000203784; -.
DR eggNOG; ENOG502RTZC; Eukaryota.
DR GeneTree; ENSGT00730000111592; -.
DR HOGENOM; CLU_2269932_0_0_1; -.
DR InParanoid; Q5T871; -.
DR OMA; PREKCPP; -.
DR OrthoDB; 1638811at2759; -.
DR PhylomeDB; Q5T871; -.
DR PathwayCommons; Q5T871; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q5T871; -.
DR BioGRID-ORCS; 149018; 12 hits in 1062 CRISPR screens.
DR GenomeRNAi; 149018; -.
DR Pharos; Q5T871; Tbio.
DR PRO; PR:Q5T871; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T871; protein.
DR Bgee; ENSG00000203784; Expressed in sperm and 106 other tissues.
DR Genevisible; Q5T871; HS.
DR InterPro; IPR026076; Lelp1.
DR Pfam; PF15042; LELP1; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..98
FT /note="Late cornified envelope-like proline-rich protein 1"
FT /id="PRO_0000271603"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 98 AA; 10697 MW; 473BDFEB85D3EEA5 CRC64;
MSSDDKSKSN DPKTEPKNCD PKCEQKCESK CQPSCLKKLL QRCFEKCPWE KCPAPPKCLP
CPSQSPSSCP PQPCTKPCPP KCPSSCPHAC PPPCPPPE
