ID   LEMA_STRGC              Reviewed;         189 AA.
AC   A8AVK0; Q9FA50;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Protein LemA;
GN   Name=lemA; OrderedLocusNames=SGO_0494;
OS   Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 /
OS   DL1 / V288).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=467705;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, OPERON STRUCTURE, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=11860552; DOI=10.1046/j.0902-0055.2001.00000.x;
RA   Vickerman M.M., Mather N.M., Minick P.E., Edwards C.A.;
RT   "Initial characterization of the Streptococcus gordonii htpX gene.";
RL   Oral Microbiol. Immunol. 17:22-31(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288;
RX   PubMed=17720781; DOI=10.1128/jb.01023-07;
RA   Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.;
RT   "Genome-wide transcriptional changes in Streptococcus gordonii in response
RT   to competence signaling peptide.";
RL   J. Bacteriol. 189:7799-7807(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Expression is maximal during the early to mid-log stage of
CC       growth and decreases after. Does not respond to heat shock up to 43
CC       degrees Celsius. Part of the lemA-htpX operon.
CC       {ECO:0000269|PubMed:11860552}.
CC   -!- DISRUPTION PHENOTYPE: No effect on extracellular glucosyltransferase
CC       activity, nor on growth characteristics. {ECO:0000269|PubMed:11860552}.
CC   -!- SIMILARITY: Belongs to the LemA family. {ECO:0000305}.
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DR   EMBL; AF017421; AAG23700.1; -; Genomic_DNA.
DR   EMBL; CP000725; ABV09455.1; -; Genomic_DNA.
DR   RefSeq; WP_012000000.1; NC_009785.1.
DR   AlphaFoldDB; A8AVK0; -.
DR   SMR; A8AVK0; -.
DR   STRING; 467705.SGO_0494; -.
DR   PRIDE; A8AVK0; -.
DR   EnsemblBacteria; ABV09455; ABV09455; SGO_0494.
DR   KEGG; sgo:SGO_0494; -.
DR   eggNOG; COG1704; Bacteria.
DR   HOGENOM; CLU_056714_0_1_9; -.
DR   OMA; VETQYQR; -.
DR   Proteomes; UP000001131; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1440.20; -; 1.
DR   InterPro; IPR023353; LemA-like_dom_sf.
DR   InterPro; IPR007156; MamQ_LemA.
DR   PANTHER; PTHR34478; PTHR34478; 1.
DR   Pfam; PF04011; LemA; 1.
DR   SUPFAM; SSF140478; SSF140478; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..189
FT                   /note="Protein LemA"
FT                   /id="PRO_0000399372"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          110..138
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   189 AA;  20962 MW;  DDA745A1EE0DBB0C CRC64;
     MSFIITIAVI VVIVLFVISV YNSLVRARMQ TQEAWSQIDV QLKRRNDLLP NLIETVKGYG
     KYEQATLEKV TQLRAQVASA SSPADAMKAS DALTRQISGI FAVAESYPDL KANENYLKLQ
     EELTNTENKI SYSRQLYNSV AGNYNVKLQA FPSNVIAGMF AFRPADFLST PEEEKAVPKV
     DFGSNGLGE