ID   LENEP_HUMAN             Reviewed;          61 AA.
AC   Q9Y5L5; B5BUM1; Q5T1A4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Lens epithelial cell protein LEP503;
GN   Name=LENEP; Synonyms=LEP503;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10655141; DOI=10.1006/exer.1999.0770;
RA   Wen Y., Sachs G., Athmann C.;
RT   "A novel lens epithelium gene, LEP503, is highly conserved in different
RT   vertebrate species and is developmentally regulated in postnatal rat
RT   lens.";
RL   Exp. Eye Res. 70:159-168(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=11376938; DOI=10.1016/s0378-1119(01)00439-5;
RA   Wen Y., Ibaraki N., Reddy V.N., Sachs G.;
RT   "Functional analysis of the promoter and chromosomal localization for human
RT   LEP503, a novel lens epithelium gene.";
RL   Gene 269:61-71(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=19054851; DOI=10.1038/nmeth.1273;
RA   Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R.,
RA   Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y.,
RA   Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.,
RA   Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y.,
RA   Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A.,
RA   Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y.,
RA   Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T.,
RA   Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y.,
RA   Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S.,
RA   Nomura N.;
RT   "Human protein factory for converting the transcriptome into an in vitro-
RT   expressed proteome.";
RL   Nat. Methods 5:1011-1017(2008).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in lens epithelial cell differentiation.
CC   -!- INTERACTION:
CC       Q9Y5L5; A0PK05: TMEM72; NbExp=3; IntAct=EBI-12913546, EBI-12878352;
CC   -!- TISSUE SPECIFICITY: Restricted to lens epithelial cells.
CC       {ECO:0000269|PubMed:11376938}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF268478; AAF73074.1; -; mRNA.
DR   EMBL; AF144412; AAD38378.1; -; Genomic_DNA.
DR   EMBL; AB451457; BAG70271.1; -; mRNA.
DR   EMBL; AL451085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471121; EAW53152.1; -; Genomic_DNA.
DR   EMBL; BC069140; AAH69140.1; -; mRNA.
DR   EMBL; BC096714; AAH96714.1; -; mRNA.
DR   EMBL; BC098148; AAH98148.1; -; mRNA.
DR   EMBL; BC098246; AAH98246.1; -; mRNA.
DR   EMBL; BC098253; AAH98253.1; -; mRNA.
DR   CCDS; CCDS1080.1; -.
DR   RefSeq; NP_061125.1; NM_018655.2.
DR   AlphaFoldDB; Q9Y5L5; -.
DR   BioGRID; 120981; 10.
DR   IntAct; Q9Y5L5; 1.
DR   STRING; 9606.ENSP00000376278; -.
DR   iPTMnet; Q9Y5L5; -.
DR   PhosphoSitePlus; Q9Y5L5; -.
DR   BioMuta; LENEP; -.
DR   PaxDb; Q9Y5L5; -.
DR   PRIDE; Q9Y5L5; -.
DR   Antibodypedia; 48815; 6 antibodies from 2 providers.
DR   DNASU; 55891; -.
DR   Ensembl; ENST00000368427.3; ENSP00000357412.3; ENSG00000163352.6.
DR   Ensembl; ENST00000392487.2; ENSP00000376278.1; ENSG00000163352.6.
DR   GeneID; 55891; -.
DR   KEGG; hsa:55891; -.
DR   MANE-Select; ENST00000392487.2; ENSP00000376278.1; NM_001394530.1; NP_001381459.1.
DR   UCSC; uc001fgi.3; human.
DR   CTD; 55891; -.
DR   DisGeNET; 55891; -.
DR   GeneCards; LENEP; -.
DR   HGNC; HGNC:14429; LENEP.
DR   HPA; ENSG00000163352; Not detected.
DR   MIM; 607377; gene.
DR   neXtProt; NX_Q9Y5L5; -.
DR   OpenTargets; ENSG00000163352; -.
DR   PharmGKB; PA30333; -.
DR   VEuPathDB; HostDB:ENSG00000163352; -.
DR   eggNOG; ENOG502SAUH; Eukaryota.
DR   GeneTree; ENSGT00390000002996; -.
DR   HOGENOM; CLU_2921930_0_0_1; -.
DR   InParanoid; Q9Y5L5; -.
DR   OMA; MQARTQP; -.
DR   OrthoDB; 1613751at2759; -.
DR   PhylomeDB; Q9Y5L5; -.
DR   TreeFam; TF341569; -.
DR   PathwayCommons; Q9Y5L5; -.
DR   SignaLink; Q9Y5L5; -.
DR   BioGRID-ORCS; 55891; 8 hits in 1048 CRISPR screens.
DR   GenomeRNAi; 55891; -.
DR   Pharos; Q9Y5L5; Tdark.
DR   PRO; PR:Q9Y5L5; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q9Y5L5; protein.
DR   Bgee; ENSG00000163352; Expressed in granulocyte and 72 other tissues.
DR   Genevisible; Q9Y5L5; HS.
DR   GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR   GO; GO:0002088; P:lens development in camera-type eye; TAS:ProtInc.
DR   InterPro; IPR029194; LEP503.
DR   PANTHER; PTHR16968; PTHR16968; 1.
DR   Pfam; PF15221; LEP503; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..61
FT                   /note="Lens epithelial cell protein LEP503"
FT                   /id="PRO_0000084403"
SQ   SEQUENCE   61 AA;  6908 MW;  677A4A062E6F97EB CRC64;
     MQPRTQPLAQ TLPFFLGGAP RDTGLRVPVI KMGTGWEGFQ RTLKEVAYIL LCCWCIKELL
     D