LENG1_HUMAN
ID LENG1_HUMAN Reviewed; 264 AA.
AC Q96BZ8; Q9HCU7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Leukocyte receptor cluster member 1;
GN Name=LENG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 63-264, AND IDENTIFICATION IN THE LRC.
RC TISSUE=Thymus;
RX PubMed=10941842; DOI=10.1007/s002510000187;
RA Wende H., Volz A., Ziegler A.;
RT "Extensive gene duplications and a large inversion characterize the human
RT leukocyte receptor cluster.";
RL Immunogenetics 51:703-713(2000).
RN [4]
RP ERRATUM OF PUBMED:10941842.
RA Wende H., Volz A., Ziegler A.;
RL Immunogenetics 52:3-4(2001).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q96BZ8; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-726510, EBI-11096309;
CC Q96BZ8; Q8WXK4-2: ASB12; NbExp=3; IntAct=EBI-726510, EBI-18394052;
CC Q96BZ8; Q8N9N5: BANP; NbExp=4; IntAct=EBI-726510, EBI-744695;
CC Q96BZ8; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-726510, EBI-742722;
CC Q96BZ8; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-726510, EBI-725606;
CC Q96BZ8; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-726510, EBI-739580;
CC Q96BZ8; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-726510, EBI-3866279;
CC Q96BZ8; Q9H257: CARD9; NbExp=3; IntAct=EBI-726510, EBI-751319;
CC Q96BZ8; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-726510, EBI-11530605;
CC Q96BZ8; Q8NA61: CBY2; NbExp=3; IntAct=EBI-726510, EBI-741724;
CC Q96BZ8; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-726510, EBI-10171570;
CC Q96BZ8; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-726510, EBI-10171416;
CC Q96BZ8; Q2TAC2: CCDC57; NbExp=3; IntAct=EBI-726510, EBI-2808286;
CC Q96BZ8; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-726510, EBI-10961624;
CC Q96BZ8; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-726510, EBI-10175300;
CC Q96BZ8; Q01850: CDR2; NbExp=6; IntAct=EBI-726510, EBI-1181367;
CC Q96BZ8; Q86X02: CDR2L; NbExp=3; IntAct=EBI-726510, EBI-11063830;
CC Q96BZ8; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-726510, EBI-10181988;
CC Q96BZ8; Q8NHQ1: CEP70; NbExp=7; IntAct=EBI-726510, EBI-739624;
CC Q96BZ8; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-726510, EBI-742054;
CC Q96BZ8; P17661: DES; NbExp=3; IntAct=EBI-726510, EBI-1055572;
CC Q96BZ8; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-726510, EBI-11988027;
CC Q96BZ8; O60447: EVI5; NbExp=3; IntAct=EBI-726510, EBI-852291;
CC Q96BZ8; A1L4K1: FSD2; NbExp=6; IntAct=EBI-726510, EBI-5661036;
CC Q96BZ8; P14136: GFAP; NbExp=3; IntAct=EBI-726510, EBI-744302;
CC Q96BZ8; Q08379: GOLGA2; NbExp=8; IntAct=EBI-726510, EBI-618309;
CC Q96BZ8; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-726510, EBI-5916454;
CC Q96BZ8; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-726510, EBI-10961706;
CC Q96BZ8; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-726510, EBI-747204;
CC Q96BZ8; Q9ULR0-1: ISY1; NbExp=3; IntAct=EBI-726510, EBI-18398632;
CC Q96BZ8; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-726510, EBI-2556193;
CC Q96BZ8; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-726510, EBI-749265;
CC Q96BZ8; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-726510, EBI-2125614;
CC Q96BZ8; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-726510, EBI-14069005;
CC Q96BZ8; P08727: KRT19; NbExp=3; IntAct=EBI-726510, EBI-742756;
CC Q96BZ8; Q15323: KRT31; NbExp=6; IntAct=EBI-726510, EBI-948001;
CC Q96BZ8; Q92764: KRT35; NbExp=3; IntAct=EBI-726510, EBI-1058674;
CC Q96BZ8; Q6A162: KRT40; NbExp=6; IntAct=EBI-726510, EBI-10171697;
CC Q96BZ8; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-726510, EBI-10171774;
CC Q96BZ8; O95751: LDOC1; NbExp=8; IntAct=EBI-726510, EBI-740738;
CC Q96BZ8; Q9P2M1: LRP2BP; NbExp=3; IntAct=EBI-726510, EBI-18273118;
CC Q96BZ8; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-726510, EBI-1216080;
CC Q96BZ8; Q8N8X9: MAB21L3; NbExp=3; IntAct=EBI-726510, EBI-10268010;
CC Q96BZ8; Q9Y6D9: MAD1L1; NbExp=3; IntAct=EBI-726510, EBI-742610;
CC Q96BZ8; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-726510, EBI-18582591;
CC Q96BZ8; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-726510, EBI-10172526;
CC Q96BZ8; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-726510, EBI-2548751;
CC Q96BZ8; Q13084: MRPL28; NbExp=3; IntAct=EBI-726510, EBI-723426;
CC Q96BZ8; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-726510, EBI-742948;
CC Q96BZ8; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-726510, EBI-11522433;
CC Q96BZ8; Q15742: NAB2; NbExp=6; IntAct=EBI-726510, EBI-8641936;
CC Q96BZ8; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-726510, EBI-10172876;
CC Q96BZ8; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-726510, EBI-741158;
CC Q96BZ8; P61970: NUTF2; NbExp=3; IntAct=EBI-726510, EBI-591778;
CC Q96BZ8; O43482: OIP5; NbExp=3; IntAct=EBI-726510, EBI-536879;
CC Q96BZ8; Q9P286: PAK5; NbExp=3; IntAct=EBI-726510, EBI-741896;
CC Q96BZ8; Q5VU43: PDE4DIP; NbExp=3; IntAct=EBI-726510, EBI-1105124;
CC Q96BZ8; P31321: PRKAR1B; NbExp=3; IntAct=EBI-726510, EBI-2805516;
CC Q96BZ8; P41219: PRPH; NbExp=3; IntAct=EBI-726510, EBI-752074;
CC Q96BZ8; P20618: PSMB1; NbExp=3; IntAct=EBI-726510, EBI-372273;
CC Q96BZ8; Q15276: RABEP1; NbExp=3; IntAct=EBI-726510, EBI-447043;
CC Q96BZ8; Q04864-2: REL; NbExp=4; IntAct=EBI-726510, EBI-10829018;
CC Q96BZ8; Q9HAT0: ROPN1; NbExp=8; IntAct=EBI-726510, EBI-1378139;
CC Q96BZ8; Q96KG9-4: SCYL1; NbExp=3; IntAct=EBI-726510, EBI-12023020;
CC Q96BZ8; Q9UM82: SPATA2; NbExp=3; IntAct=EBI-726510, EBI-744066;
CC Q96BZ8; O75558: STX11; NbExp=3; IntAct=EBI-726510, EBI-714135;
CC Q96BZ8; P15884: TCF4; NbExp=3; IntAct=EBI-726510, EBI-533224;
CC Q96BZ8; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-726510, EBI-11139477;
CC Q96BZ8; Q9BXU0: TEX12; NbExp=3; IntAct=EBI-726510, EBI-12090309;
CC Q96BZ8; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-726510, EBI-1105213;
CC Q96BZ8; Q8WW34: TMEM239; NbExp=3; IntAct=EBI-726510, EBI-9675724;
CC Q96BZ8; Q12933: TRAF2; NbExp=3; IntAct=EBI-726510, EBI-355744;
CC Q96BZ8; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-726510, EBI-492476;
CC Q96BZ8; P36406: TRIM23; NbExp=3; IntAct=EBI-726510, EBI-740098;
CC Q96BZ8; P14373: TRIM27; NbExp=3; IntAct=EBI-726510, EBI-719493;
CC Q96BZ8; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-726510, EBI-2130429;
CC Q96BZ8; Q86WV8: TSC1; NbExp=3; IntAct=EBI-726510, EBI-12806590;
CC Q96BZ8; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-726510, EBI-607755;
CC Q96BZ8; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-726510, EBI-11524408;
CC Q96BZ8; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-726510, EBI-739895;
CC Q96BZ8; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-726510, EBI-12030590;
CC Q96BZ8; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-726510, EBI-527853;
CC -!- MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present
CC on 19q13.4.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG01393.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC245052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC014986; AAH14986.1; -; mRNA.
DR EMBL; AF211966; AAG01393.1; ALT_INIT; mRNA.
DR CCDS; CCDS12881.1; -.
DR RefSeq; NP_077292.2; NM_024316.2.
DR AlphaFoldDB; Q96BZ8; -.
DR BioGRID; 122582; 123.
DR IntAct; Q96BZ8; 93.
DR MINT; Q96BZ8; -.
DR STRING; 9606.ENSP00000222224; -.
DR GlyGen; Q96BZ8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96BZ8; -.
DR PhosphoSitePlus; Q96BZ8; -.
DR BioMuta; LENG1; -.
DR DMDM; 74731296; -.
DR EPD; Q96BZ8; -.
DR jPOST; Q96BZ8; -.
DR MassIVE; Q96BZ8; -.
DR MaxQB; Q96BZ8; -.
DR PaxDb; Q96BZ8; -.
DR PeptideAtlas; Q96BZ8; -.
DR PRIDE; Q96BZ8; -.
DR ProteomicsDB; 76133; -.
DR Antibodypedia; 46337; 229 antibodies from 18 providers.
DR DNASU; 79165; -.
DR Ensembl; ENST00000222224.4; ENSP00000222224.3; ENSG00000105617.4.
DR Ensembl; ENST00000610998.1; ENSP00000481386.1; ENSG00000276959.1.
DR Ensembl; ENST00000613622.1; ENSP00000478485.1; ENSG00000278516.1.
DR Ensembl; ENST00000614037.1; ENSP00000483164.1; ENSG00000276774.1.
DR Ensembl; ENST00000616103.1; ENSP00000481252.1; ENSG00000277808.1.
DR Ensembl; ENST00000616816.1; ENSP00000480516.1; ENSG00000277457.1.
DR Ensembl; ENST00000617592.1; ENSP00000481079.1; ENSG00000278426.1.
DR Ensembl; ENST00000619669.1; ENSP00000477607.1; ENSG00000276628.1.
DR Ensembl; ENST00000621285.1; ENSP00000479538.1; ENSG00000278257.1.
DR Ensembl; ENST00000621927.1; ENSP00000481948.1; ENSG00000275935.1.
DR GeneID; 79165; -.
DR KEGG; hsa:79165; -.
DR MANE-Select; ENST00000222224.4; ENSP00000222224.3; NM_024316.3; NP_077292.2.
DR UCSC; uc002qdm.4; human.
DR CTD; 79165; -.
DR GeneCards; LENG1; -.
DR HGNC; HGNC:15502; LENG1.
DR HPA; ENSG00000105617; Low tissue specificity.
DR neXtProt; NX_Q96BZ8; -.
DR OpenTargets; ENSG00000105617; -.
DR PharmGKB; PA134904804; -.
DR VEuPathDB; HostDB:ENSG00000105617; -.
DR eggNOG; ENOG502RZ97; Eukaryota.
DR GeneTree; ENSGT00510000048131; -.
DR HOGENOM; CLU_058751_2_0_1; -.
DR InParanoid; Q96BZ8; -.
DR OrthoDB; 1518973at2759; -.
DR PhylomeDB; Q96BZ8; -.
DR TreeFam; TF317830; -.
DR PathwayCommons; Q96BZ8; -.
DR SignaLink; Q96BZ8; -.
DR BioGRID-ORCS; 79165; 192 hits in 1075 CRISPR screens.
DR ChiTaRS; LENG1; human.
DR GenomeRNAi; 79165; -.
DR Pharos; Q96BZ8; Tdark.
DR PRO; PR:Q96BZ8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96BZ8; protein.
DR Bgee; ENSG00000105617; Expressed in sural nerve and 97 other tissues.
DR Genevisible; Q96BZ8; HS.
DR InterPro; IPR019339; CIR_N_dom.
DR InterPro; IPR039875; LENG1-like.
DR PANTHER; PTHR22093; PTHR22093; 1.
DR Pfam; PF10197; Cir_N; 1.
DR SMART; SM01083; Cir_N; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..264
FT /note="Leukocyte receptor cluster member 1"
FT /id="PRO_0000254627"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 16..46
FT /evidence="ECO:0000255"
FT COILED 89..115
FT /evidence="ECO:0000255"
FT COILED 196..222
FT /evidence="ECO:0000255"
FT COMPBIAS 8..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..147
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 59
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 245
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332"
FT VARIANT 97
FT /note="K -> E (in dbSNP:rs35089861)"
FT /id="VAR_051090"
SQ SEQUENCE 264 AA; 30528 MW; 324AD76EA1165C44 CRC64;
MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL RKKARHQNSL
PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYKEEK RQEKERQEKA LGILTYLGQS
AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI KSRLDPLREM QKHLGKKRQH GGDEGSRSRK
EKEGSEKQRP KEPPSLDQLR AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR
RRYNSQFNPQ LARRPRQQDP HLTH
