LENG8_HUMAN
ID LENG8_HUMAN Reviewed; 800 AA.
AC Q96PV6; A0A087WTE7; B0VJY9; Q8IZ27; Q8NCX6;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Leukocyte receptor cluster member 8;
GN Name=LENG8; Synonyms=KIAA1932;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION IN COMPLEX WITH SEM1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16239144; DOI=10.1016/j.cell.2005.08.019;
RA Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N.,
RA Shiekhattar R.;
RT "Integrator, a multiprotein mediator of small nuclear RNA processing,
RT associates with the C-terminal repeat of RNA polymerase II.";
RL Cell 123:265-276(2005).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP VARIANT LYS-661.
RX PubMed=30237576; DOI=10.1038/s41436-018-0138-x;
RA Maddirevula S., Alzahrani F., Al-Owain M., Al Muhaizea M.A., Kayyali H.R.,
RA AlHashem A., Rahbeeni Z., Al-Otaibi M., Alzaidan H.I., Balobaid A.,
RA El Khashab H.Y., Bubshait D.K., Faden M., Yamani S.A., Dabbagh O.,
RA Al-Mureikhi M., Jasser A.A., Alsaif H.S., Alluhaydan I., Seidahmed M.Z.,
RA Alabbasi B.H., Almogarri I., Kurdi W., Akleh H., Qari A., Al Tala S.M.,
RA Alhomaidi S., Kentab A.Y., Salih M.A., Chedrawi A., Alameer S., Tabarki B.,
RA Shamseldin H.E., Patel N., Ibrahim N., Abdulwahab F., Samira M., Goljan E.,
RA Abouelhoda M., Meyer B.F., Hashem M., Shaheen R., AlShahwan S.,
RA Alfadhel M., Ben-Omran T., Al-Qattan M.M., Monies D., Alkuraya F.S.;
RT "Autozygome and high throughput confirmation of disease genes candidacy.";
RL Genet. Med. 21:736-742(2019).
CC -!- SUBUNIT: May be part of a SEM1-containing complex.
CC {ECO:0000269|PubMed:16239144}.
CC -!- INTERACTION:
CC Q96PV6; Q8IWG5: ANKHD1; NbExp=3; IntAct=EBI-739546, EBI-355540;
CC Q96PV6; Q03989: ARID5A; NbExp=3; IntAct=EBI-739546, EBI-948603;
CC Q96PV6; Q86V38: ATN1; NbExp=3; IntAct=EBI-739546, EBI-11954292;
CC Q96PV6; O95817: BAG3; NbExp=3; IntAct=EBI-739546, EBI-747185;
CC Q96PV6; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-739546, EBI-12809220;
CC Q96PV6; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-739546, EBI-1383687;
CC Q96PV6; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-739546, EBI-739624;
CC Q96PV6; Q96M91: CFAP53; NbExp=3; IntAct=EBI-739546, EBI-742422;
CC Q96PV6; Q14746: COG2; NbExp=3; IntAct=EBI-739546, EBI-389449;
CC Q96PV6; Q8N684-3: CPSF7; NbExp=3; IntAct=EBI-739546, EBI-11523759;
CC Q96PV6; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-739546, EBI-3867333;
CC Q96PV6; Q92997: DVL3; NbExp=3; IntAct=EBI-739546, EBI-739789;
CC Q96PV6; A8MTA8-2: FAM166B; NbExp=3; IntAct=EBI-739546, EBI-12160437;
CC Q96PV6; B7ZLH0: FAM22F; NbExp=3; IntAct=EBI-739546, EBI-10220102;
CC Q96PV6; P14136: GFAP; NbExp=3; IntAct=EBI-739546, EBI-744302;
CC Q96PV6; Q14687: GSE1; NbExp=3; IntAct=EBI-739546, EBI-372619;
CC Q96PV6; Q9UGU5: HMGXB4; NbExp=3; IntAct=EBI-739546, EBI-7261162;
CC Q96PV6; P52272: HNRNPM; NbExp=3; IntAct=EBI-739546, EBI-486809;
CC Q96PV6; P04792: HSPB1; NbExp=3; IntAct=EBI-739546, EBI-352682;
CC Q96PV6; Q9Y6K9: IKBKG; NbExp=3; IntAct=EBI-739546, EBI-81279;
CC Q96PV6; Q0VD86: INCA1; NbExp=3; IntAct=EBI-739546, EBI-6509505;
CC Q96PV6; Q5TA45: INTS11; NbExp=3; IntAct=EBI-739546, EBI-748258;
CC Q96PV6; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-739546, EBI-1055254;
CC Q96PV6; O60333-2: KIF1B; NbExp=3; IntAct=EBI-739546, EBI-10975473;
CC Q96PV6; Q14847-2: LASP1; NbExp=3; IntAct=EBI-739546, EBI-9088686;
CC Q96PV6; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-739546, EBI-716006;
CC Q96PV6; Q8NDC0: MAPK1IP1L; NbExp=5; IntAct=EBI-739546, EBI-741424;
CC Q96PV6; Q5JRA6: MIA3; NbExp=3; IntAct=EBI-739546, EBI-2291868;
CC Q96PV6; P35548: MSX2; NbExp=3; IntAct=EBI-739546, EBI-6447480;
CC Q96PV6; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-739546, EBI-5662487;
CC Q96PV6; Q53F19: NCBP3; NbExp=7; IntAct=EBI-739546, EBI-6657994;
CC Q96PV6; P19404: NDUFV2; NbExp=3; IntAct=EBI-739546, EBI-713665;
CC Q96PV6; Q5JVF3: PCID2; NbExp=3; IntAct=EBI-739546, EBI-1051701;
CC Q96PV6; O15055: PER2; NbExp=3; IntAct=EBI-739546, EBI-1054296;
CC Q96PV6; P60891: PRPS1; NbExp=3; IntAct=EBI-739546, EBI-749195;
CC Q96PV6; P09012: SNRPA; NbExp=8; IntAct=EBI-739546, EBI-607085;
CC Q96PV6; O14512: SOCS7; NbExp=3; IntAct=EBI-739546, EBI-1539606;
CC Q96PV6; Q92734: TFG; NbExp=3; IntAct=EBI-739546, EBI-357061;
CC Q96PV6; Q08117-2: TLE5; NbExp=3; IntAct=EBI-739546, EBI-11741437;
CC Q96PV6; Q15025: TNIP1; NbExp=3; IntAct=EBI-739546, EBI-357849;
CC Q96PV6; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-739546, EBI-3650647;
CC Q96PV6; Q99816: TSG101; NbExp=3; IntAct=EBI-739546, EBI-346882;
CC Q96PV6; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-739546, EBI-11957216;
CC Q96PV6; O76024: WFS1; NbExp=3; IntAct=EBI-739546, EBI-720609;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96PV6-2; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96PV6-1; Sequence=VSP_059456, VSP_059457;
CC Name=3;
CC IsoId=Q96PV6-3; Sequence=VSP_059455;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB67825.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB067519; BAB67825.1; ALT_INIT; mRNA.
DR EMBL; AL834532; CAD39188.2; -; mRNA.
DR EMBL; AC008746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC245884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU207370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU467002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72248.1; -; Genomic_DNA.
DR EMBL; BC028048; AAH28048.1; -; mRNA.
DR CCDS; CCDS12894.1; -. [Q96PV6-2]
DR RefSeq; NP_443157.1; NM_052925.3. [Q96PV6-2]
DR RefSeq; XP_011524717.1; XM_011526415.2. [Q96PV6-2]
DR AlphaFoldDB; Q96PV6; -.
DR SMR; Q96PV6; -.
DR BioGRID; 125373; 147.
DR CORUM; Q96PV6; -.
DR IntAct; Q96PV6; 101.
DR MINT; Q96PV6; -.
DR STRING; 9606.ENSP00000318374; -.
DR GlyGen; Q96PV6; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q96PV6; -.
DR PhosphoSitePlus; Q96PV6; -.
DR SwissPalm; Q96PV6; -.
DR BioMuta; LENG8; -.
DR DMDM; 158705886; -.
DR EPD; Q96PV6; -.
DR jPOST; Q96PV6; -.
DR MassIVE; Q96PV6; -.
DR MaxQB; Q96PV6; -.
DR PeptideAtlas; Q96PV6; -.
DR PRIDE; Q96PV6; -.
DR ProteomicsDB; 77774; -. [Q96PV6-1]
DR ProteomicsDB; 77775; -. [Q96PV6-2]
DR ProteomicsDB; 77776; -. [Q96PV6-3]
DR Antibodypedia; 46360; 58 antibodies from 18 providers.
DR DNASU; 114823; -.
DR Ensembl; ENST00000326764.10; ENSP00000318374.5; ENSG00000167615.17. [Q96PV6-2]
DR Ensembl; ENST00000610314.2; ENSP00000484494.1; ENSG00000274305.4. [Q96PV6-1]
DR Ensembl; ENST00000611866.2; ENSP00000479293.1; ENSG00000276681.4. [Q96PV6-1]
DR Ensembl; ENST00000616932.4; ENSP00000477813.1; ENSG00000167615.17. [Q96PV6-1]
DR Ensembl; ENST00000617180.4; ENSP00000480663.1; ENSG00000276681.4. [Q96PV6-2]
DR Ensembl; ENST00000617420.2; ENSP00000481040.1; ENSG00000276458.4. [Q96PV6-1]
DR Ensembl; ENST00000621306.4; ENSP00000478337.1; ENSG00000276458.4. [Q96PV6-2]
DR Ensembl; ENST00000622672.4; ENSP00000478975.1; ENSG00000274305.4. [Q96PV6-2]
DR GeneID; 114823; -.
DR KEGG; hsa:114823; -.
DR MANE-Select; ENST00000326764.10; ENSP00000318374.5; NM_052925.4; NP_443157.1.
DR UCSC; uc032iea.2; human. [Q96PV6-2]
DR UCSC; uc061cqz.1; human.
DR CTD; 114823; -.
DR DisGeNET; 114823; -.
DR GeneCards; LENG8; -.
DR HGNC; HGNC:15500; LENG8.
DR HPA; ENSG00000167615; Low tissue specificity.
DR MIM; 616575; gene.
DR neXtProt; NX_Q96PV6; -.
DR OpenTargets; ENSG00000167615; -.
DR PharmGKB; PA134903953; -.
DR VEuPathDB; HostDB:ENSG00000167615; -.
DR eggNOG; KOG1861; Eukaryota.
DR GeneTree; ENSGT00390000008006; -.
DR HOGENOM; CLU_014160_1_0_1; -.
DR InParanoid; Q96PV6; -.
DR OMA; PHFYSNQ; -.
DR PhylomeDB; Q96PV6; -.
DR TreeFam; TF312927; -.
DR PathwayCommons; Q96PV6; -.
DR SignaLink; Q96PV6; -.
DR BioGRID-ORCS; 114823; 434 hits in 1083 CRISPR screens.
DR ChiTaRS; LENG8; human.
DR GenomeRNAi; 114823; -.
DR Pharos; Q96PV6; Tdark.
DR PRO; PR:Q96PV6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96PV6; protein.
DR Bgee; ENSG00000167615; Expressed in right uterine tube and 93 other tissues.
DR ExpressionAtlas; Q96PV6; baseline and differential.
DR Genevisible; Q96PV6; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR045107; SAC3/GANP/THP3.
DR InterPro; IPR005062; SAC3/GANP/THP3_conserved.
DR PANTHER; PTHR12436; PTHR12436; 1.
DR Pfam; PF03399; SAC3_GANP; 1.
DR PROSITE; PS50250; PCI; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..800
FT /note="Leukocyte receptor cluster member 8"
FT /id="PRO_0000306391"
FT DOMAIN 636..800
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 24..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 351
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 38..783
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_059455"
FT VAR_SEQ 106..142
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11572484"
FT /id="VSP_059456"
FT VAR_SEQ 748..800
FT /note="FRPALPVSYLQAELAFEGEAACRAFLEPLGLAYTGPDNSSIDCRLSLAQLSA
FT F -> YVVPSSLLPLLFPSFRLVSSCIKLSPCPLLPLPPVFLLIFFSPFPPSLSAFFPW
FT FSTGKTVPPSLPPSSAM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11572484"
FT /id="VSP_059457"
FT VARIANT 279
FT /note="R -> P (in dbSNP:rs35061854)"
FT /id="VAR_035294"
FT VARIANT 557
FT /note="I -> V (in dbSNP:rs35336528)"
FT /id="VAR_035295"
FT VARIANT 661
FT /note="E -> K (found in a patient with developmental delay,
FT hypotonia since birth and dysmorphic features such as
FT triangular face, brachycephaly epicanthal fold,
FT hypertelorism, broad nasal bridge and strabismus; unknown
FT pathological significance)"
FT /evidence="ECO:0000269|PubMed:30237576"
FT /id="VAR_082146"
SQ SEQUENCE 800 AA; 88157 MW; DCD37905D54D1544 CRC64;
MAANVGDQRS TDWSSQYSMV AGAGRENGME TPMHENPEWE KARQALASIS KSGAAGGSAK
SSSNGPVASA QYVSQAEASA LQQQQYYQWY QQYNYAYPYS YYYPMSMYQS YGSPSQYGMA
GSYGSATPQQ PSAPQHQGTL NQPPVPGMDE SMSYQAPPQQ LPSAQPPQPS NPPHGAHTLN
SGPQPGTAPA TQHSQAGPAT GQAYGPHTYT EPAKPKKGQQ LWNRMKPAPG TGGLKFNIQK
RPFAVTTQSF GSNAEGQHSG FGPQPNPEKV QNHSGSSARG NLSGKPDDWP QDMKEYVERC
FTACESEEDK DRTEKLLKEV LQARLQDGSA YTIDWSREPL PGLTREPVAE SPKKKRWEAA
SSLHPPRGAG SATRGGGAPS QRGTPGAGGA GRARGNSFTK FGNRNVFMKD NSSSSSTDSR
SRSSSRSPTR HFRRSDSHSD SDSSYSGNEC HPVGRRNPPP KGRGGRGAHM DRGRGRAQRG
KRHDLAPTKR SRKKMAALEC EDPERELKKQ KRAARFQHGH SRRLRLEPLV LQMSSLESSG
ADPDWQELQI VGTCPDITKH YLRLTCAPDP STVRPVAVLK KSLCMVKCHW KEKQDYAFAC
EQMKSIRQDL TVQGIRTEFT VEVYETHARI ALEKGDHEEF NQCQTQLKSL YAENLPGNVG
EFTAYRILYY IFTKNSGDIT TELAYLTREL KADPCVAHAL ALRTAWALGN YHRFFRLYCH
APCMSGYLVD KFADRERKVA LKAMIKTFRP ALPVSYLQAE LAFEGEAACR AFLEPLGLAY
TGPDNSSIDC RLSLAQLSAF
