LENG8_MOUSE
ID LENG8_MOUSE Reviewed; 785 AA.
AC Q8CBY3; Q3TCN4; Q8C3P0; Q8CGB8;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Leukocyte receptor cluster member 8 homolog;
GN Name=Leng8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Diencephalon, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 44-59, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
CC -!- SUBUNIT: May be part of a SEM1-containing complex.
CC {ECO:0000250|UniProtKB:Q96PV6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CBY3-1; Sequence=Displayed;
CC Name=3;
CC IsoId=Q8CBY3-3; Sequence=VSP_028464, VSP_028465;
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DR EMBL; AK034310; BAC28671.1; -; mRNA.
DR EMBL; AK085304; BAC39415.1; -; mRNA.
DR EMBL; AK170629; BAE41922.1; -; mRNA.
DR EMBL; BC042658; AAH42658.1; -; mRNA.
DR EMBL; BC066768; AAH66768.1; -; mRNA.
DR CCDS; CCDS20731.1; -. [Q8CBY3-1]
DR RefSeq; NP_766324.1; NM_172736.3. [Q8CBY3-1]
DR AlphaFoldDB; Q8CBY3; -.
DR SMR; Q8CBY3; -.
DR BioGRID; 231296; 5.
DR STRING; 10090.ENSMUSP00000046465; -.
DR iPTMnet; Q8CBY3; -.
DR PhosphoSitePlus; Q8CBY3; -.
DR EPD; Q8CBY3; -.
DR MaxQB; Q8CBY3; -.
DR PaxDb; Q8CBY3; -.
DR PRIDE; Q8CBY3; -.
DR ProteomicsDB; 286184; -. [Q8CBY3-1]
DR ProteomicsDB; 286185; -. [Q8CBY3-3]
DR Antibodypedia; 46360; 58 antibodies from 18 providers.
DR DNASU; 232798; -.
DR Ensembl; ENSMUST00000037472; ENSMUSP00000046465; ENSMUSG00000035545. [Q8CBY3-1]
DR Ensembl; ENSMUST00000117274; ENSMUSP00000113223; ENSMUSG00000035545. [Q8CBY3-3]
DR GeneID; 232798; -.
DR KEGG; mmu:232798; -.
DR UCSC; uc009exb.1; mouse. [Q8CBY3-3]
DR UCSC; uc009exc.1; mouse. [Q8CBY3-1]
DR CTD; 114823; -.
DR MGI; MGI:2142195; Leng8.
DR VEuPathDB; HostDB:ENSMUSG00000035545; -.
DR eggNOG; KOG1861; Eukaryota.
DR GeneTree; ENSGT00390000008006; -.
DR HOGENOM; CLU_1980923_0_0_1; -.
DR InParanoid; Q8CBY3; -.
DR TreeFam; TF312927; -.
DR BioGRID-ORCS; 232798; 13 hits in 61 CRISPR screens.
DR ChiTaRS; Leng8; mouse.
DR PRO; PR:Q8CBY3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8CBY3; protein.
DR Bgee; ENSMUSG00000035545; Expressed in retinal neural layer and 241 other tissues.
DR ExpressionAtlas; Q8CBY3; baseline and differential.
DR Genevisible; Q8CBY3; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR045107; SAC3/GANP/THP3.
DR InterPro; IPR005062; SAC3/GANP/THP3_conserved.
DR PANTHER; PTHR12436; PTHR12436; 1.
DR Pfam; PF03399; SAC3_GANP; 1.
DR PROSITE; PS50250; PCI; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Direct protein sequencing;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96PV6"
FT CHAIN 2..785
FT /note="Leukocyte receptor cluster member 8 homolog"
FT /id="PRO_0000306392"
FT DOMAIN 637..785
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q96PV6"
FT MOD_RES 352
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96PV6"
FT VAR_SEQ 107..126
FT /note="SMYQSYGSPSQYGMASSYGS -> VRTWLQGGSLLSGWANGWLG (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028464"
FT VAR_SEQ 127..785
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028465"
FT CONFLICT 754
FT /note="S -> P (in Ref. 1; BAE41922)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 785 AA; 86767 MW; D2C6AA92B0D5AC25 CRC64;
MAANVGDQRA ADWSSQYSMV TGNSRENGME TPMHENPEWE KARQALASIS KAGATSSSKA
SSSGPVASAQ YVSQAEASAL QQQQQQYYQW YQQYNYAYPY SYYYPMSMYQ SYGSPSQYGM
ASSYGSATAQ QPSAPQHQGT LNQPPVPGMD ESMAYQASPQ QLPAAQPPQP SNSQHGTHSL
SNGPQPGTAP STQHSQAGAP TGQAYGPHSY SEPAKPKKGQ QLWTRMKPAP GTGGLKFNIQ
KRPFAVTSQS FSSNSEGQHS SFGPQPNSEN TQNRSGPSGR GNLSGKPDDW PQDMKEYVER
CFTACESEED KDRTEKLLKE VLQARLQDGS AYTIDWSREP LPGLTREPVA ESPKKKRWEA
PSSLHPSRGA GSVTRGGGAQ SQRGTPGAGG AGRARGSSFT KFGNRNVFMK DNSSSSSTDS
RSRSSSRSPT RHFRRSDSHS DSDSSYSGNE CHPVGRRNPP PKGRGGRGAH MDRGRGRAQR
GKRHDLAPTK RSRKKMAALE CEDPERELKK QKRAARFQHG HSRRLRLEPL VLQMSNLESS
GADPDWQELQ IVGTCPDITK HYLRLTCAPD PSTVRPVAVL KKSLCMVKSH WKEKQDYAFA
CEQMKSIRQD LTVQGIRTEF TVEVYETHAR IALEKGDHEE FNQCQTQLKS LYAENLAGNV
GEFTAYRILY YIFTKNSGDI TTELAYLTRE MKADPCVAHA LALRAAWALG NYHRFFRLYC
HAPCMSGYLV DKFADRERKA ALKAMIKTYV ALHSAAFCAV ALPRPLRILV SLQLLCWSPL
PVPCS
