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LENG9_HUMAN
ID   LENG9_HUMAN             Reviewed;         501 AA.
AC   Q96B70; B2VAM3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   25-MAY-2022, entry version 136.
DE   RecName: Full=Leukocyte receptor cluster member 9;
GN   Name=LENG9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-23 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH15921.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC008746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU207370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471135; EAW72251.1; -; Genomic_DNA.
DR   EMBL; BC015921; AAH15921.1; ALT_INIT; mRNA.
DR   RefSeq; NP_945339.2; NM_198988.1.
DR   AlphaFoldDB; Q96B70; -.
DR   SMR; Q96B70; -.
DR   BioGRID; 125106; 6.
DR   IntAct; Q96B70; 4.
DR   MINT; Q96B70; -.
DR   STRING; 9606.ENSP00000479355; -.
DR   GlyGen; Q96B70; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q96B70; -.
DR   PhosphoSitePlus; Q96B70; -.
DR   BioMuta; LENG9; -.
DR   DMDM; 296434565; -.
DR   EPD; Q96B70; -.
DR   jPOST; Q96B70; -.
DR   MassIVE; Q96B70; -.
DR   MaxQB; Q96B70; -.
DR   PaxDb; Q96B70; -.
DR   PeptideAtlas; Q96B70; -.
DR   PRIDE; Q96B70; -.
DR   ProteomicsDB; 76052; -.
DR   DNASU; 94059; -.
DR   Ensembl; ENST00000614111.1; ENSP00000483600.1; ENSG00000274495.1.
DR   Ensembl; ENST00000622419.1; ENSP00000477636.1; ENSG00000273574.1.
DR   GeneID; 94059; -.
DR   UCSC; uc032jrx.2; human.
DR   CTD; 94059; -.
DR   GeneCards; LENG9; -.
DR   HGNC; HGNC:16306; LENG9.
DR   neXtProt; NX_Q96B70; -.
DR   PharmGKB; PA134975056; -.
DR   eggNOG; ENOG502QQIY; Eukaryota.
DR   InParanoid; Q96B70; -.
DR   OrthoDB; 1210602at2759; -.
DR   PhylomeDB; Q96B70; -.
DR   TreeFam; TF329287; -.
DR   PathwayCommons; Q96B70; -.
DR   SignaLink; Q96B70; -.
DR   BioGRID-ORCS; 94059; 12 hits in 1062 CRISPR screens.
DR   ChiTaRS; LENG9; human.
DR   GenomeRNAi; 94059; -.
DR   Pharos; Q96B70; Tdark.
DR   PRO; PR:Q96B70; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q96B70; protein.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009097; Cyclic_Pdiesterase.
DR   InterPro; IPR019510; Kinase-A_anchor_nucl_local_sig.
DR   InterPro; IPR042653; Leng9.
DR   InterPro; IPR040459; MJ1316.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR46729; PTHR46729; 1.
DR   Pfam; PF10469; AKAP7_NLS; 1.
DR   Pfam; PF04457; MJ1316; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF55144; SSF55144; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..501
FT                   /note="Leukocyte receptor cluster member 9"
FT                   /id="PRO_0000263688"
FT   ZN_FING         40..67
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          61..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         153
FT                   /note="H -> R (in dbSNP:rs10406453)"
FT                   /id="VAR_029602"
FT   VARIANT         499
FT                   /note="R -> P (in dbSNP:rs10423424)"
FT                   /id="VAR_029603"
SQ   SEQUENCE   501 AA;  53167 MW;  6AF04904A6518554 CRC64;
     MGSRPPCGAT SSARRACQFP APMAAAREPE LPQEAPATEP APPPACRFFL EGRCRFGARC
     RQPHPGAPAP PGREAQPEAG AKKPPLRTAA DVIQRIRWDP RLDPADFSVG YVDRFLGVRE
     EPFSAFCWDQ PLAALGPGVL AVPQHRVRFF RFHGRLVWDR ASRTDLVFGS GSAAGRGPTI
     LDAPNTEGAH GAEGAEWTLA GTGQEAQAAP KRGSTRPLCT GHQEPGVEEP GELEAAQERA
     LGTAADLGTL APRGRLAGVT EEALKPTAAT RTTLLGGKEA QALGVPGGSA ETTEAEWGPA
     AWPEDKRARL SVAAPCQPRP THFVALMVTE PGLQAEVTKA QEYLVHVAPH CANFLVPSQN
     LHLTLALLRL AGAGEEAAAI GALRRALLAP GLNAPPRLSF RKLVLLGPHV LCAPPSPTLE
     SMAQVLSQRL EAEGLSTLQS PGQLHPHLTV AKVPHGSQVH LPKLEFTLSQ EVGCQPLQTL
     WLCRIGRTGG PFQPLAEIRL E
 
 
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