LENG9_HUMAN
ID LENG9_HUMAN Reviewed; 501 AA.
AC Q96B70; B2VAM3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=Leukocyte receptor cluster member 9;
GN Name=LENG9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CAUTION: It is uncertain whether Met-1 or Met-23 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH15921.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC008746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU207370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72251.1; -; Genomic_DNA.
DR EMBL; BC015921; AAH15921.1; ALT_INIT; mRNA.
DR RefSeq; NP_945339.2; NM_198988.1.
DR AlphaFoldDB; Q96B70; -.
DR SMR; Q96B70; -.
DR BioGRID; 125106; 6.
DR IntAct; Q96B70; 4.
DR MINT; Q96B70; -.
DR STRING; 9606.ENSP00000479355; -.
DR GlyGen; Q96B70; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96B70; -.
DR PhosphoSitePlus; Q96B70; -.
DR BioMuta; LENG9; -.
DR DMDM; 296434565; -.
DR EPD; Q96B70; -.
DR jPOST; Q96B70; -.
DR MassIVE; Q96B70; -.
DR MaxQB; Q96B70; -.
DR PaxDb; Q96B70; -.
DR PeptideAtlas; Q96B70; -.
DR PRIDE; Q96B70; -.
DR ProteomicsDB; 76052; -.
DR DNASU; 94059; -.
DR Ensembl; ENST00000614111.1; ENSP00000483600.1; ENSG00000274495.1.
DR Ensembl; ENST00000622419.1; ENSP00000477636.1; ENSG00000273574.1.
DR GeneID; 94059; -.
DR UCSC; uc032jrx.2; human.
DR CTD; 94059; -.
DR GeneCards; LENG9; -.
DR HGNC; HGNC:16306; LENG9.
DR neXtProt; NX_Q96B70; -.
DR PharmGKB; PA134975056; -.
DR eggNOG; ENOG502QQIY; Eukaryota.
DR InParanoid; Q96B70; -.
DR OrthoDB; 1210602at2759; -.
DR PhylomeDB; Q96B70; -.
DR TreeFam; TF329287; -.
DR PathwayCommons; Q96B70; -.
DR SignaLink; Q96B70; -.
DR BioGRID-ORCS; 94059; 12 hits in 1062 CRISPR screens.
DR ChiTaRS; LENG9; human.
DR GenomeRNAi; 94059; -.
DR Pharos; Q96B70; Tdark.
DR PRO; PR:Q96B70; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96B70; protein.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR009097; Cyclic_Pdiesterase.
DR InterPro; IPR019510; Kinase-A_anchor_nucl_local_sig.
DR InterPro; IPR042653; Leng9.
DR InterPro; IPR040459; MJ1316.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR46729; PTHR46729; 1.
DR Pfam; PF10469; AKAP7_NLS; 1.
DR Pfam; PF04457; MJ1316; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF55144; SSF55144; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..501
FT /note="Leukocyte receptor cluster member 9"
FT /id="PRO_0000263688"
FT ZN_FING 40..67
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 153
FT /note="H -> R (in dbSNP:rs10406453)"
FT /id="VAR_029602"
FT VARIANT 499
FT /note="R -> P (in dbSNP:rs10423424)"
FT /id="VAR_029603"
SQ SEQUENCE 501 AA; 53167 MW; 6AF04904A6518554 CRC64;
MGSRPPCGAT SSARRACQFP APMAAAREPE LPQEAPATEP APPPACRFFL EGRCRFGARC
RQPHPGAPAP PGREAQPEAG AKKPPLRTAA DVIQRIRWDP RLDPADFSVG YVDRFLGVRE
EPFSAFCWDQ PLAALGPGVL AVPQHRVRFF RFHGRLVWDR ASRTDLVFGS GSAAGRGPTI
LDAPNTEGAH GAEGAEWTLA GTGQEAQAAP KRGSTRPLCT GHQEPGVEEP GELEAAQERA
LGTAADLGTL APRGRLAGVT EEALKPTAAT RTTLLGGKEA QALGVPGGSA ETTEAEWGPA
AWPEDKRARL SVAAPCQPRP THFVALMVTE PGLQAEVTKA QEYLVHVAPH CANFLVPSQN
LHLTLALLRL AGAGEEAAAI GALRRALLAP GLNAPPRLSF RKLVLLGPHV LCAPPSPTLE
SMAQVLSQRL EAEGLSTLQS PGQLHPHLTV AKVPHGSQVH LPKLEFTLSQ EVGCQPLQTL
WLCRIGRTGG PFQPLAEIRL E