LENG9_MOUSE
ID LENG9_MOUSE Reviewed; 485 AA.
AC Q8BTN6; Q3UYM5; Q8BTG8;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Leukocyte receptor cluster member 9;
GN Name=Leng9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Amnion, Medulla oblongata, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AK089196; BAC40788.1; -; mRNA.
DR EMBL; AK090365; BAC41185.1; -; mRNA.
DR EMBL; AK134559; BAE22187.1; -; mRNA.
DR EMBL; AK147019; BAE27612.1; -; mRNA.
DR EMBL; AC101941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116676; AAI16677.1; -; mRNA.
DR EMBL; CH466627; EDL31225.1; -; Genomic_DNA.
DR CCDS; CCDS20732.1; -.
DR RefSeq; NP_780738.1; NM_175529.3.
DR AlphaFoldDB; Q8BTN6; -.
DR SMR; Q8BTN6; -.
DR STRING; 10090.ENSMUSP00000061079; -.
DR iPTMnet; Q8BTN6; -.
DR PhosphoSitePlus; Q8BTN6; -.
DR MaxQB; Q8BTN6; -.
DR PaxDb; Q8BTN6; -.
DR PeptideAtlas; Q8BTN6; -.
DR PRIDE; Q8BTN6; -.
DR ProteomicsDB; 291938; -.
DR Antibodypedia; 72623; 73 antibodies from 13 providers.
DR DNASU; 243813; -.
DR Ensembl; ENSMUST00000058358; ENSMUSP00000061079; ENSMUSG00000043432.
DR GeneID; 243813; -.
DR KEGG; mmu:243813; -.
DR UCSC; uc009exd.1; mouse.
DR CTD; 94059; -.
DR MGI; MGI:2444509; Leng9.
DR VEuPathDB; HostDB:ENSMUSG00000043432; -.
DR eggNOG; ENOG502QS4D; Eukaryota.
DR GeneTree; ENSGT00390000010577; -.
DR HOGENOM; CLU_044135_0_0_1; -.
DR InParanoid; Q8BTN6; -.
DR OMA; GQASPWT; -.
DR OrthoDB; 1210602at2759; -.
DR PhylomeDB; Q8BTN6; -.
DR TreeFam; TF329287; -.
DR BioGRID-ORCS; 243813; 0 hits in 74 CRISPR screens.
DR PRO; PR:Q8BTN6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BTN6; protein.
DR Bgee; ENSMUSG00000043432; Expressed in jejunum and 122 other tissues.
DR Genevisible; Q8BTN6; MM.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR009097; Cyclic_Pdiesterase.
DR InterPro; IPR019510; Kinase-A_anchor_nucl_local_sig.
DR InterPro; IPR042653; Leng9.
DR InterPro; IPR040459; MJ1316.
DR InterPro; IPR041367; Znf-CCCH_4.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR46729; PTHR46729; 1.
DR Pfam; PF10469; AKAP7_NLS; 1.
DR Pfam; PF04457; MJ1316; 1.
DR Pfam; PF18044; zf-CCCH_4; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF55144; SSF55144; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..485
FT /note="Leukocyte receptor cluster member 9"
FT /id="PRO_0000415826"
FT ZN_FING 8..35
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 212..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 62
FT /note="R -> G (in Ref. 1; BAE22187)"
FT /evidence="ECO:0000305"
FT CONFLICT 63
FT /note="R -> G (in Ref. 1; BAC41185)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="A -> V (in Ref. 1; BAC41185)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 485 AA; 52613 MW; 98B03A4379141E21 CRC64;
MEASADSSEA PAVCRFFLEG RCRFGARCRQ PHPGAPAPSP VVTQPEAGSK KPALRTAADV
IRRIRWDPRL DPADFSVGYT DRFLGVQEEP FCAFCWDEPL AALGPGVLAV PQHRIRYFRF
RGRLVWDRAS RTDLIFGSGS VAGRGPTILD ALDGGDEHWT EVTAEIPDTE KTGVGLEGLD
TQDALAEAGG NPTGTGLDSG LETHEEGGAI KETRTGLDSS LETPEVDGPT KETGLNGTTE
LEMPDPSMNF SGVKISSVEE PRATLLPQWQ AQGMETKGLS AEEMGNVWDP GVWPDDRRAP
RQPRPTHFVA LMVTESGLRA EVVKAQEHLV RIAPSCAEFL VPAQALHLTV VLLRLTGPGE
EAAAARALRR AILKPGLQAP SQLQFRDLVL LGHHVLCATP SPTLTGMAQT LNQRLEAEGL
RVVLLPELQP HLTLAKVPHG TQVCLPKPEY TLNQELGRQP LSKLWLCRMG RAGHSYLPLV
EISLK
