ID   LEO1_XENLA              Reviewed;         703 AA.
AC   Q52KV5;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=RNA polymerase-associated protein LEO1;
GN   Name=leo1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple
CC       functions during transcription by RNA polymerase II. PAF1C associates
CC       with RNA polymerase II, is involved in transcriptional elongation and
CC       in histone modifications including methylation on histone H3 'Lys-4'
CC       (H3K4me3) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the PAF1 complex, which at least consists of
CC       cdc73, paf1, leo1, ctr9 and rtf1 (By similarity). The PAF1 complex
CC       interacts with PHF5A (By similarity). {ECO:0000250|UniProtKB:Q5XJE5,
CC       ECO:0000250|UniProtKB:Q8WVC0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LEO1 family. {ECO:0000305}.
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DR   EMBL; BC094174; AAH94174.1; -; mRNA.
DR   RefSeq; NP_001085280.1; NM_001091811.2.
DR   AlphaFoldDB; Q52KV5; -.
DR   SMR; Q52KV5; -.
DR   BioGRID; 101772; 1.
DR   IntAct; Q52KV5; 1.
DR   DNASU; 443607; -.
DR   GeneID; 443607; -.
DR   KEGG; xla:443607; -.
DR   CTD; 443607; -.
DR   Xenbase; XB-GENE-5828312; leo1.S.
DR   OrthoDB; 1071475at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 443607; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
DR   GO; GO:0016570; P:histone modification; IEA:InterPro.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.
DR   InterPro; IPR007149; Leo1.
DR   PANTHER; PTHR23146; PTHR23146; 1.
DR   Pfam; PF04004; Leo1; 1.
PE   2: Evidence at transcript level;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..703
FT                   /note="RNA polymerase-associated protein LEO1"
FT                   /id="PRO_0000247824"
FT   REGION          1..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          553..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          578..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          627..703
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          242..279
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        25..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..342
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        578..595
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        627..662
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        669..694
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   703 AA;  80407 MW;  FEB68652F09D103A CRC64;
     MADMEDLFGS DAESENEQKE SDSGSGSDSE PGNDGSGSNR SGSDSDRDED DEHSAVKPSN
     KELFGDDSED EVGSQHSGSY NRSERSYNAS ETAHSDQEVN DQSDAEQHSG SEALHDEDND
     EDVGQRSDHS SPRSEADGSD KDANSDDEKW GREDKSDQSD EEEKMQNSDD ELQHSDRDEH
     RQSDEEGQRP SSDAEEQETH QSDDEEQDNH HSDDLHNSDD EENDQQHYND RPHSDGEEQD
     HRQSEDEENE LQHSDDEQER QRSDDERQRS DDEINEHRQS DDEDRQHSDG DNVRHHSDDE
     HKSESQKGSD SEEEIGRQRR KKAIASDSDL DSDDDEPKAK QNASDLFGDA DDISSGSDGE
     DKPPTPGQPM DDDGMDQDQP EETAPETRIE VEIPKVNTDL GNDLYFVKLP NFLSVEPRPF
     DPQYYEDEFE DEEMLDEEGR TRLKLKVENT IRWRTRKDEE GNDVRDSNAR IVKWSDGSMS
     LHLGNEVFDV YKAPLQGDHN HLFIRQGTGL QGQAVFKTKL TFRPHSTDSA THRKMTLSLA
     DRCSKTQKIR ILPMAGRDPE SQRSEMIKKE EERLRASIRR ESQQRRMREK QHQRGLSANY
     LEPDRYDDEE EGDESISLAA IKNRYKGGRE ERARIYSSDS DEGSDEDKAQ RLLKAKKLNS
     DEEDQDEEGE ISGKRKAEED EDKASKKPKK YVISDDEEDE EEL