ID   ARF2_BOVIN              Reviewed;         181 AA.
AC   P84081; A4FUC3; P10947; P16500;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=ADP-ribosylation factor 2;
GN   Name=ARF2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3135549; DOI=10.1073/pnas.85.15.5488;
RA   Price S.R., Nightingale M., Tsai S.-C., Williamson K.C., Adamik R.,
RA   Chen H.-C., Moss J., Vaughan M.;
RT   "Guanine nucleotide-binding proteins that enhance choleragen ADP-
RT   ribosyltransferase activity: nucleotide and deduced amino acid sequence of
RT   an ADP-ribosylation factor cDNA.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:5488-5491(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Retina;
RX   PubMed=8444865; DOI=10.1016/s0021-9258(18)53476-1;
RA   Serventi I.M., Cavanaugh E., Moss J., Vaughan M.;
RT   "Characterization of the gene for ADP-ribosylation factor (ARF) 2, a
RT   developmentally regulated, selectively expressed member of the ARF family
RT   of approximately 20-kDa guanine nucleotide-binding proteins.";
RL   J. Biol. Chem. 268:4863-4872(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: GTP-binding protein that functions as an allosteric activator
CC       of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
CC       Involved in protein trafficking; may modulate vesicle budding and
CC       uncoating within the Golgi apparatus.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; J03794; AAA30383.1; -; mRNA.
DR   EMBL; M88287; AAA30754.1; -; mRNA.
DR   EMBL; M88292; AAA18982.1; -; Genomic_DNA.
DR   EMBL; M88289; AAA18982.1; JOINED; Genomic_DNA.
DR   EMBL; M88290; AAA18982.1; JOINED; Genomic_DNA.
DR   EMBL; M88291; AAA18982.1; JOINED; Genomic_DNA.
DR   EMBL; BC114693; AAI14694.1; -; mRNA.
DR   PIR; A45422; A45422.
DR   RefSeq; NP_777114.1; NM_174689.3.
DR   AlphaFoldDB; P84081; -.
DR   SMR; P84081; -.
DR   STRING; 9913.ENSBTAP00000008925; -.
DR   PaxDb; P84081; -.
DR   PeptideAtlas; P84081; -.
DR   PRIDE; P84081; -.
DR   Ensembl; ENSBTAT00000008925; ENSBTAP00000008925; ENSBTAG00000006785.
DR   GeneID; 282601; -.
DR   KEGG; bta:282601; -.
DR   CTD; 11841; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006785; -.
DR   eggNOG; KOG0070; Eukaryota.
DR   GeneTree; ENSGT00950000183080; -.
DR   HOGENOM; CLU_040729_9_3_1; -.
DR   InParanoid; P84081; -.
DR   OrthoDB; 1362554at2759; -.
DR   TreeFam; TF300808; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000006785; Expressed in diaphragm and 105 other tissues.
DR   ExpressionAtlas; P84081; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd04150; Arf1_5_like; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045872; Arf1-5-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Myristate;
KW   Nucleotide-binding; Protein transport; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..181
FT                   /note="ADP-ribosylation factor 2"
FT                   /id="PRO_0000207383"
FT   BINDING         24..31
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         67..71
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         126..129
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   181 AA;  20746 MW;  95BE17A962B83016 CRC64;
     MGNVFEKLFK SLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
     ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELTRM LAEDELRDAV
     LLVFVNKQDL PNAMNAAEIT DKLGLHSLRQ RNWYIQATCA TSGDGLYEGL DWLSNQLKNQ
     K