ARF3_MOUSE
ID ARF3_MOUSE Reviewed; 181 AA.
AC P61205; P16587;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=ADP-ribosylation factor 3;
GN Name=Arf3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ICR; TISSUE=Brain;
RX PubMed=8947846; DOI=10.1093/oxfordjournals.jbchem.a021484;
RA Hosaka M., Toda K., Takatsu H., Torii S., Murakami K., Nakayama K.;
RT "Structure and intracellular localization of mouse ADP-ribosylation factors
RT type 1 to type 6 (ARF1-ARF6).";
RL J. Biochem. 120:813-819(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: GTP-binding protein that functions as an allosteric activator
CC of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
CC Involved in protein trafficking; may modulate vesicle budding and
CC uncoating within the Golgi apparatus.
CC -!- SUBUNIT: Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at
CC the Golgi complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cytoplasm,
CC perinuclear region {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; D87900; BAA13492.1; -; mRNA.
DR EMBL; BC014778; AAH14778.1; -; mRNA.
DR EMBL; BC024935; AAH24935.1; -; mRNA.
DR CCDS; CCDS27804.1; -.
DR PIR; JC4947; JC4947.
DR RefSeq; NP_031504.1; NM_007478.3.
DR RefSeq; XP_011243747.1; XM_011245445.1.
DR AlphaFoldDB; P61205; -.
DR SMR; P61205; -.
DR BioGRID; 198186; 48.
DR IntAct; P61205; 7.
DR MINT; P61205; -.
DR STRING; 10090.ENSMUSP00000050689; -.
DR iPTMnet; P61205; -.
DR PhosphoSitePlus; P61205; -.
DR SwissPalm; P61205; -.
DR jPOST; P61205; -.
DR PaxDb; P61205; -.
DR PeptideAtlas; P61205; -.
DR PRIDE; P61205; -.
DR ProteomicsDB; 283199; -.
DR TopDownProteomics; P61205; -.
DR Antibodypedia; 25743; 125 antibodies from 28 providers.
DR DNASU; 11842; -.
DR Ensembl; ENSMUST00000053183; ENSMUSP00000050689; ENSMUSG00000051853.
DR GeneID; 11842; -.
DR KEGG; mmu:11842; -.
DR UCSC; uc007xnp.1; mouse.
DR CTD; 377; -.
DR MGI; MGI:99432; Arf3.
DR VEuPathDB; HostDB:ENSMUSG00000051853; -.
DR eggNOG; KOG0070; Eukaryota.
DR GeneTree; ENSGT00950000183080; -.
DR HOGENOM; CLU_040729_9_3_1; -.
DR InParanoid; P61205; -.
DR OMA; LWRILNI; -.
DR OrthoDB; 1362554at2759; -.
DR PhylomeDB; P61205; -.
DR TreeFam; TF300808; -.
DR Reactome; R-MMU-1660514; Synthesis of PIPs at the Golgi membrane.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR BioGRID-ORCS; 11842; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Arf3; mouse.
DR PRO; PR:P61205; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P61205; protein.
DR Bgee; ENSMUSG00000051853; Expressed in nucleus accumbens and 260 other tissues.
DR ExpressionAtlas; P61205; baseline and differential.
DR Genevisible; P61205; MM.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; TAS:MGI.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISO:MGI.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd04150; Arf1_5_like; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR045872; Arf1-5-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein;
KW Myristate; Nucleotide-binding; Protein transport; Reference proteome;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..181
FT /note="ADP-ribosylation factor 3"
FT /id="PRO_0000207387"
FT BINDING 24..31
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 67..71
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 126..129
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 181 AA; 20601 MW; D6FA234DFAED3E5F CRC64;
MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV
LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLANQLKNK
K
