ARF3_RAT
ID ARF3_RAT Reviewed; 181 AA.
AC P61206; P16587;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=ADP-ribosylation factor 3;
DE AltName: Full=Liver regeneration-related protein LRRG202;
GN Name=Arf3; ORFNames=Ac1-253;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=8813705; DOI=10.1007/bf00226058;
RA Price S.R., Nightingale M.S., Tsuchiya M., Moss J., Vaughan M.;
RT "Interspecies relationships among ADP-ribosylation factors (ARFs): evidence
RT of evolutionary pressure to maintain individual identities.";
RL Mol. Cell. Biochem. 159:15-23(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RA Xu C.S., Li W.Q., Li Y.C., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F.,
RA Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT "Liver regeneration after PH.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: GTP-binding protein that functions as an allosteric activator
CC of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
CC Involved in protein trafficking; may modulate vesicle budding and
CC uncoating within the Golgi apparatus.
CC -!- SUBUNIT: Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at
CC the Golgi complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cytoplasm,
CC perinuclear region {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; L12382; AAA40687.1; -; mRNA.
DR EMBL; AY325223; AAP92624.1; -; mRNA.
DR EMBL; BC088865; AAH88865.1; -; mRNA.
DR RefSeq; NP_543180.1; NM_080904.2.
DR RefSeq; XP_006257382.1; XM_006257320.3.
DR RefSeq; XP_017450124.1; XM_017594635.1.
DR RefSeq; XP_017450125.1; XM_017594636.1.
DR AlphaFoldDB; P61206; -.
DR SMR; P61206; -.
DR BioGRID; 250874; 3.
DR IntAct; P61206; 3.
DR MINT; P61206; -.
DR STRING; 10116.ENSRNOP00000047811; -.
DR iPTMnet; P61206; -.
DR PhosphoSitePlus; P61206; -.
DR World-2DPAGE; 0004:P61206; -.
DR jPOST; P61206; -.
DR PaxDb; P61206; -.
DR PRIDE; P61206; -.
DR Ensembl; ENSRNOT00000077884; ENSRNOP00000069538; ENSRNOG00000054775.
DR GeneID; 140940; -.
DR KEGG; rno:140940; -.
DR UCSC; RGD:621273; rat.
DR CTD; 377; -.
DR RGD; 621273; Arf3.
DR eggNOG; KOG0070; Eukaryota.
DR GeneTree; ENSGT00950000183080; -.
DR HOGENOM; CLU_040729_9_3_1; -.
DR InParanoid; P61206; -.
DR OrthoDB; 1362554at2759; -.
DR PhylomeDB; P61206; -.
DR TreeFam; TF300808; -.
DR Reactome; R-RNO-1660514; Synthesis of PIPs at the Golgi membrane.
DR Reactome; R-RNO-6807878; COPI-mediated anterograde transport.
DR Reactome; R-RNO-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:P61206; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000054775; Expressed in frontal cortex and 19 other tissues.
DR ExpressionAtlas; P61206; baseline and differential.
DR Genevisible; P61206; RN.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISO:RGD.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd04150; Arf1_5_like; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR045872; Arf1-5-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein;
KW Myristate; Nucleotide-binding; Protein transport; Reference proteome;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..181
FT /note="ADP-ribosylation factor 3"
FT /id="PRO_0000207389"
FT BINDING 24..31
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 67..71
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 126..129
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 181 AA; 20601 MW; D6FA234DFAED3E5F CRC64;
MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV
LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLANQLKNK
K
