ID   ARF4_XENLA              Reviewed;         180 AA.
AC   P51644; Q5D083;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=ADP-ribosylation factor 4;
GN   Name=arf4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Boman A.L.;
RL   Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16824954; DOI=10.1016/j.devcel.2006.04.019;
RA   Hyodo-Miura J., Yamamoto T.S., Hyodo A.C., Iemura S., Kusakabe M.,
RA   Nishida E., Natsume T., Ueno N.;
RT   "XGAP, an ArfGAP, is required for polarized localization of PAR proteins
RT   and cell polarity in Xenopus gastrulation.";
RL   Dev. Cell 11:69-79(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: GTP-binding protein involved in protein trafficking; may
CC       modulate vesicle budding and uncoating within the Golgi apparatus.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       P51644; P29403: rho; NbExp=2; IntAct=EBI-7491013, EBI-7490990;
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; U31460; AAA74951.1; -; mRNA.
DR   EMBL; AB195295; BAE94176.1; -; mRNA.
DR   EMBL; BC054189; AAH54189.1; -; mRNA.
DR   RefSeq; NP_001082540.1; NM_001089071.1.
DR   RefSeq; NP_001090186.1; NM_001096717.1.
DR   AlphaFoldDB; P51644; -.
DR   SMR; P51644; -.
DR   IntAct; P51644; 1.
DR   MINT; P51644; -.
DR   DNASU; 398551; -.
DR   GeneID; 398551; -.
DR   GeneID; 779066; -.
DR   KEGG; xla:398551; -.
DR   KEGG; xla:779066; -.
DR   CTD; 398551; -.
DR   CTD; 779066; -.
DR   Xenbase; XB-GENE-865045; arf4.L.
DR   Xenbase; XB-GENE-17334699; arf4.S.
DR   OMA; CATQGEG; -.
DR   OrthoDB; 1362554at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 398551; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   CDD; cd04150; Arf1_5_like; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045872; Arf1-5-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   1: Evidence at protein level;
KW   ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Myristate;
KW   Nucleotide-binding; Protein transport; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..180
FT                   /note="ADP-ribosylation factor 4"
FT                   /id="PRO_0000207395"
FT   BINDING         24..31
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         67..71
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         126..129
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   180 AA;  20586 MW;  91E98C2D857D7504 CRC64;
     MGLTISSLFS RLFGKKQMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
     ICFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERI QEAAEELQKM LQEDELRDAV
     LLVFANKQDL PNAMAISEMT DKLTLQTLRN RTWYVQATCA TQGTGLYEGL DWLSNELSKR