ID   LEPA_ORYLA              Reviewed;         155 AA.
AC   Q588F9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Leptin-A;
DE   Flags: Precursor;
GN   Name=lepa;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15808904; DOI=10.1016/j.peptides.2004.12.017;
RA   Kurokawa T., Uji S., Suzuki T.;
RT   "Identification of cDNA coding for a homologue to mammalian leptin from
RT   pufferfish, Takifugu rubripes.";
RL   Peptides 26:745-750(2005).
RN   [2]
RP   SEQUENCE REVISION TO 41; 47 AND 75, AND TISSUE SPECIFICITY.
RX   PubMed=19523397; DOI=10.1016/j.ygcen.2009.01.008;
RA   Kurokawa T., Murashita K.;
RT   "Genomic characterization of multiple leptin genes and a leptin receptor
RT   gene in the Japanese medaka, Oryzias latipes.";
RL   Gen. Comp. Endocrinol. 161:229-237(2009).
CC   -!- FUNCTION: May function as part of a signaling pathway that acts to
CC       regulate the size of the body fat depot. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed at moderate levels in the liver.
CC       Expressed at low levels in skin, gill, muscle, intestine and eye
CC       tissue. {ECO:0000269|PubMed:19523397}.
CC   -!- SIMILARITY: Belongs to the leptin family. {ECO:0000305}.
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DR   EMBL; AB193548; BAD94448.2; -; mRNA.
DR   RefSeq; NP_001098190.2; NM_001104720.3.
DR   AlphaFoldDB; Q588F9; -.
DR   SMR; Q588F9; -.
DR   Ensembl; ENSORLT00000012053; ENSORLP00000012052; ENSORLG00000009612.
DR   GeneID; 100049298; -.
DR   KEGG; ola:100049298; -.
DR   CTD; 100150233; -.
DR   GeneTree; ENSGT00530000066614; -.
DR   HOGENOM; CLU_1643161_0_0_1; -.
DR   InParanoid; Q588F9; -.
DR   OMA; RQGHCSE; -.
DR   OrthoDB; 1317008at2759; -.
DR   Proteomes; UP000001038; Chromosome 6.
DR   Proteomes; UP000265180; Unplaced.
DR   Proteomes; UP000265200; Unplaced.
DR   Bgee; ENSORLG00000009612; Expressed in pharyngeal gill and 1 other tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Obesity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..155
FT                   /note="Leptin-A"
FT                   /id="PRO_0000042929"
FT   DISULFID        110..155
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   155 AA;  17266 MW;  10C1A6A28EA5D38B CRC64;
     MDSALVLFAF LFHCLNVATA APVNPELQEM KSNVIDIAKE LSLRLESIIQ TSIGPKFSPP
     SDELNGLSSI MAVLDECTNQ ISDNFDEAKK IKVDISSLMD SMSEWSDKHC GEQPSTQAEN
     QTSRRFSITE SMQAVTRLKH FLLLLQNNSD QLEIC