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ARFB_MYCTU
ID   ARFB_MYCTU              Reviewed;          50 AA.
AC   P9WJG7; L0T7U8; P64755; Q10558;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Uncharacterized membrane protein ArfB;
GN   Name=arfB; OrderedLocusNames=Rv0900; ORFNames=MTCY31.28;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21410778; DOI=10.1111/j.1365-2958.2011.07619.x;
RA   Song H., Huff J., Janik K., Walter K., Keller C., Ehlers S., Bossmann S.H.,
RA   Niederweis M.;
RT   "Expression of the ompATb operon accelerates ammonia secretion and
RT   adaptation of Mycobacterium tuberculosis to acidic environments.";
RL   Mol. Microbiol. 80:900-918(2011).
CC   -!- FUNCTION: Required for wild-type expression of ArfA and ammonia
CC       secretion, not however part of an ammonia transporter.
CC       {ECO:0000269|PubMed:21410778}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Part of the arfA-arfB-arfC operon.
CC       {ECO:0000269|PubMed:21410778}.
CC   -!- DISRUPTION PHENOTYPE: Upon operon disruption no reduction of serine
CC       uptake at pH 6.9, no visible effect on outer membrane permeability,
CC       however severe delays in ammonia secretion, medium pH neutralization
CC       and growth also occur at pH 5.5. Reduced expression of ArfA.
CC       {ECO:0000269|PubMed:21410778}.
CC   -!- SIMILARITY: Belongs to the ArfB membrane protein family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43648.1; -; Genomic_DNA.
DR   PIR; A70783; A70783.
DR   RefSeq; NP_215415.1; NC_000962.3.
DR   RefSeq; WP_003404687.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; P9WJG7; -.
DR   SMR; P9WJG7; -.
DR   STRING; 83332.Rv0900; -.
DR   PaxDb; P9WJG7; -.
DR   DNASU; 885179; -.
DR   GeneID; 45424863; -.
DR   GeneID; 885179; -.
DR   KEGG; mtu:Rv0900; -.
DR   TubercuList; Rv0900; -.
DR   eggNOG; ENOG5031QE3; Bacteria.
DR   OMA; WYLLAFV; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051701; P:biological process involved in interaction with host; IMP:MTBBASE.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..50
FT                   /note="Uncharacterized membrane protein ArfB"
FT                   /id="PRO_0000014083"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   50 AA;  5245 MW;  4F1BC1FDF9758FE1 CRC64;
     MDFVIQWSCY LLAFLGGSAV AWVVVTLSIK RASRDEGAAE APSAAETGAQ
 
 
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