ID   LEPB_ASPFN              Reviewed;         565 AA.
AC   B8NJG5;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Probable transcription factor lepB {ECO:0000303|PubMed:26051490};
DE   AltName: Full=Leporins biosynthesis protein B {ECO:0000303|PubMed:26051490};
GN   Name=lepB {ECO:0000303|PubMed:26051490}; ORFNames=AFLA_066860;
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS   / JCM 12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=332952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC   167;
RX   PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
RN   [2]
RP   IDENTIFICATION OF THE GENE CLUSTER 23, AND FUNCTION.
RX   PubMed=20447271; DOI=10.1111/j.1364-3703.2009.00594.x;
RA   Georgianna D.R., Fedorova N.D., Burroughs J.L., Dolezal A.L., Bok J.W.,
RA   Horowitz-Brown S., Woloshuk C.P., Yu J., Keller N.P., Payne G.A.;
RT   "Beyond aflatoxin: four distinct expression patterns and functional roles
RT   associated with Aspergillus flavus secondary metabolism gene clusters.";
RL   Mol. Plant Pathol. 11:213-226(2010).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=26051490; DOI=10.1016/j.fgb.2015.05.010;
RA   Cary J.W., Uka V., Han Z., Buyst D., Harris-Coward P.Y., Ehrlich K.C.,
RA   Wei Q., Bhatnagar D., Dowd P.F., Martens S.L., Calvo A.M., Martins J.C.,
RA   Vanhaecke L., Coenye T., De Saeger S., Di Mavungu J.D.;
RT   "An Aspergillus flavus secondary metabolic gene cluster containing a hybrid
RT   PKS-NRPS is necessary for synthesis of the 2-pyridones, leporins.";
RL   Fungal Genet. Biol. 81:88-97(2015).
CC   -!- FUNCTION: Probable transcription factor; part of the gene cluster 23
CC       that mediates the biosynthesis of a family of 2-pyridones known as
CC       leporins (PubMed:20447271, PubMed:26051490).
CC       {ECO:0000269|PubMed:26051490, ECO:0000305|PubMed:20447271}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Does not affect the expression of the leporins
CC       cluster (PubMed:26051490). {ECO:0000269|PubMed:26051490}.
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DR   EMBL; EQ963479; EED49864.1; -; Genomic_DNA.
DR   RefSeq; XP_002380245.1; XM_002380204.1.
DR   AlphaFoldDB; B8NJG5; -.
DR   PRIDE; B8NJG5; -.
DR   EnsemblFungi; EED49864; EED49864; AFLA_066860.
DR   VEuPathDB; FungiDB:AFLA_066860; -.
DR   eggNOG; ENOG502SJ9D; Eukaryota.
DR   HOGENOM; CLU_013260_4_0_1; -.
DR   OMA; YPRNIND; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   Pfam; PF04082; Fungal_trans; 1.
PE   4: Predicted;
KW   Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..565
FT                   /note="Probable transcription factor lepB"
FT                   /id="PRO_0000438459"
FT   REGION          52..259
FT                   /note="Fungal specific transcription factor domain"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   565 AA;  63990 MW;  262A2777E17B21F6 CRC64;
     MSNGVSVRVL AVQQALETEF SLVEASGNPS SVGSCVARVW LPPKNEATWL LKRYAEDVTY
     LHHILHLPSV RQQMEDLYKQ LSLGLRIEPC HVALILSIFA STAYTLTPLT GGDAVFTNEQ
     TAVKCAFLWS KMALDVLEHS SRSTPGSIED IQATIILSFV IFNFEGFTMR FRALSASALT
     MARDLSLHRL DARPDRLPGP HAPLDSDIGR EIKRRVWWHM VSTDWILALS GGPQEGTYLM
     HPAHMRVNYP RNLDDRDLDR YNPQYSRPLS QPTAMTYTLL RIQLADICRS AIDALPPPFS
     DWGEVNYDRF ISLDQRFEAF IRSLPVFFRL DEASRHQSRD VEHQYPQIIV QRYILWSTLQ
     GRRSKLNQPF LTRVSMNPRY QYSRKVCLQS ARCVIELKAL MDHDMASLAS AHVRLATFLH
     NYFLATAVLV MDLCLNKEGG SSEDRRQEIV DACRVLQEAE ATSPMASRFL KSLMDILQKY
     QIQVLPATTV PDVRPLSANT GASGVPDPNL SDRDLVNPSQ ILPSTYDPLE NANIDDLWQN
     FINLDQNCSP GSWDHLFSAL DSRIV