ID   LEPB_ORYLA              Reviewed;         158 AA.
AC   B9X0L5;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Leptin-B {ECO:0000312|EMBL:BAH24202.2};
DE   Flags: Precursor;
GN   Name=LEP-B {ECO:0000312|EMBL:BAH24202.2};
GN   Synonyms=ob-b {ECO:0000312|EMBL:CAP45848.1};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1] {ECO:0000312|EMBL:BAH24202.2}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Brain {ECO:0000312|EMBL:BAH24202.2};
RX   PubMed=19523397; DOI=10.1016/j.ygcen.2009.01.008;
RA   Kurokawa T., Murashita K.;
RT   "Genomic characterization of multiple leptin genes and a leptin receptor
RT   gene in the Japanese medaka, Oryzias latipes.";
RL   Gen. Comp. Endocrinol. 161:229-237(2009).
RN   [2] {ECO:0000312|EMBL:CAP45848.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=19293295; DOI=10.1677/joe-09-0034;
RA   Gorissen M., Bernier N.J., Nabuurs S.B., Flik G., Huising M.O.;
RT   "Two divergent leptin paralogues in zebrafish (Danio rerio) that originate
RT   early in teleostean evolution.";
RL   J. Endocrinol. 201:329-339(2009).
CC   -!- FUNCTION: May function as part of a signaling pathway that acts to
CC       regulate the size of the body fat depot.
CC       {ECO:0000250|UniProtKB:P41159}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P41159}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the brain and eye. Expressed at
CC       low levels in muscle and skin. {ECO:0000269|PubMed:19523397}.
CC   -!- SIMILARITY: Belongs to the leptin family. {ECO:0000255}.
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DR   EMBL; AB457589; BAH24202.2; -; mRNA.
DR   EMBL; BN001183; CAP45848.1; -; mRNA.
DR   RefSeq; NP_001153914.1; NM_001160442.2.
DR   AlphaFoldDB; B9X0L5; -.
DR   SMR; B9X0L5; -.
DR   Ensembl; ENSORLT00000027678; ENSORLP00000037008; ENSORLG00000021942.
DR   GeneID; 100301595; -.
DR   KEGG; ola:100301595; -.
DR   CTD; 100301595; -.
DR   GeneTree; ENSGT01030000234865; -.
DR   InParanoid; B9X0L5; -.
DR   OrthoDB; 1400177at2759; -.
DR   Proteomes; UP000001038; Chromosome 23.
DR   Proteomes; UP000265180; Unplaced.
DR   Proteomes; UP000265200; Unplaced.
DR   Bgee; ENSORLG00000021942; Expressed in pharyngeal gill and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..158
FT                   /note="Leptin-B"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000412718"
FT   DISULFID        114..158
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   158 AA;  17763 MW;  07B2F2F55A7EFE7B CRC64;
     MYMPLALVYA SFLTLPASTS PATKGNVIQI QVHNIVNLAQ TTVAHIRKLR MQLLMAPPIE
     ITTPPIKGLA SFSHYLKHLD NELQSPDTDL LSQIQADVSS LDGKVQSLGL MMNCPFQPRP
     TAEVSRFLFP DIHHYWTIAK VENYLESLHL NRDKLKVC