ID   LEPH_STAAU              Reviewed;         174 AA.
AC   P0A066; P72364;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Inactive signal peptidase IA;
GN   Name=spsA;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WCUH29 / NCIMB 40771;
RX   PubMed=8824617; DOI=10.1128/jb.178.19.5712-5718.1996;
RA   Cregg K.M., Wilding E.I., Black M.T.;
RT   "Molecular cloning and expression of the spsB gene encoding an essential
RT   type I signal peptidase from Staphylococcus aureus.";
RL   J. Bacteriol. 178:5712-5718(1996).
CC   -!- FUNCTION: Catalytically inactive.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S26 family. {ECO:0000305}.
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DR   EMBL; U65000; AAC44434.1; -; Genomic_DNA.
DR   RefSeq; WP_000758209.1; NZ_WHRV01000074.1.
DR   AlphaFoldDB; P0A066; -.
DR   SMR; P0A066; -.
DR   OMA; NDNRKNH; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR   CDD; cd06530; S26_SPase_I; 1.
DR   InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019533; Peptidase_S26.
DR   PANTHER; PTHR43390; PTHR43390; 1.
DR   Pfam; PF10502; Peptidase_S26; 1.
DR   PRINTS; PR00727; LEADERPTASE.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   TIGRFAMs; TIGR02227; sigpep_I_bact; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..174
FT                   /note="Inactive signal peptidase IA"
FT                   /id="PRO_0000109525"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..174
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   174 AA;  20146 MW;  A382F874DA980C62 CRC64;
     MKKVVKYLIS LILAIIIVLF VQTFVIVGHV IPNNDMSPTL NKGDRVIVNK IKVTFNQLNN
     GDIITYRRGN EIYTSRIIAK PGQSMAFRQG QLYRDDRPVD ASYAKNRKIK DFSLRNFKEL
     DGDIIPPNNF VVLNDHDNNQ HDSRQFGLID KKDIIGNISL RYYPFSKWTI QFKS