ID   LEPT_LEPPE              Reviewed;          22 AA.
AC   P86267;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Leptoglycin {ECO:0000303|PubMed:19298834};
OS   Leptodactylus pentadactylus (Smokey jungle frog) (Rana pentadactyla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Leptodactylidae; Leptodactylinae;
OC   Leptodactylus.
OX   NCBI_TaxID=47564;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Skin secretion;
RX   PubMed=19298834; DOI=10.1016/j.toxicon.2009.03.011;
RA   Sousa J.C., Berto R.F., Gois E.A., Fontenele-Cardi N.C.,
RA   Honorio-Junior J.E.R., Konno K., Richardson M., Rocha M.F.G.,
RA   Camargo A.A.C.M., Pimenta D.C., Cardi B.A., Carvalho K.M.;
RT   "Leptoglycin: a new glycine/leucine-rich antimicrobial peptide isolated
RT   from the skin secretion of the South American frog Leptodactylus
RT   pentadactylus (Leptodactylidae).";
RL   Toxicon 54:23-32(2009).
CC   -!- FUNCTION: Antimicrobial protein. Has antibacterial activity against the
CC       Gram-negative bacteria E.coli ATCC 28922 (MIC=50 uM), P.aeruginosa ATCC
CC       9027 (MIC=8 uM) and C.freundii ATCC 8090 (MIC=75 uM). Does not have
CC       hemolytic activity. {ECO:0000269|PubMed:19298834}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19298834}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:19298834}.
CC   -!- MASS SPECTROMETRY: Mass=1762.068; Mass_error=0.05; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:19298834};
CC   -!- MASS SPECTROMETRY: Mass=1761.6; Mass_error=1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:19298834};
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DR   AlphaFoldDB; P86267; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Secreted.
FT   PEPTIDE         1..22
FT                   /note="Leptoglycin"
FT                   /evidence="ECO:0000269|PubMed:19298834"
FT                   /id="PRO_0000371254"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   22 AA;  1762 MW;  1EB20B4E1F18A3ED CRC64;
     GLLGGLLGPL LGGGGGGGGG LL