ID   LEP_AQUAE               Reviewed;         256 AA.
AC   O67088;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Signal peptidase I;
DE            Short=SPase I;
DE            EC=3.4.21.89;
DE   AltName: Full=Leader peptidase I;
GN   Name=lepB; OrderedLocusNames=aq_955;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC         from secreted and periplasmic proteins.; EC=3.4.21.89;
CC   -!- SIMILARITY: Belongs to the peptidase S26 family. {ECO:0000305}.
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DR   EMBL; AE000657; AAC07042.1; -; Genomic_DNA.
DR   PIR; E70382; E70382.
DR   RefSeq; NP_213651.1; NC_000918.1.
DR   RefSeq; WP_010880589.1; NC_000918.1.
DR   AlphaFoldDB; O67088; -.
DR   SMR; O67088; -.
DR   STRING; 224324.aq_955; -.
DR   MEROPS; S26.025; -.
DR   EnsemblBacteria; AAC07042; AAC07042; aq_955.
DR   KEGG; aae:aq_955; -.
DR   PATRIC; fig|224324.8.peg.749; -.
DR   eggNOG; COG0681; Bacteria.
DR   HOGENOM; CLU_028723_1_3_0; -.
DR   InParanoid; O67088; -.
DR   OMA; SDSRFWG; -.
DR   OrthoDB; 1741894at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006465; P:signal peptide processing; IBA:GO_Central.
DR   CDD; cd06530; S26_SPase_I; 1.
DR   InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR   InterPro; IPR019757; Pept_S26A_signal_pept_1_Lys-AS.
DR   InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR   InterPro; IPR019533; Peptidase_S26.
DR   PANTHER; PTHR43390; PTHR43390; 1.
DR   Pfam; PF10502; Peptidase_S26; 1.
DR   PRINTS; PR00727; LEADERPTASE.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   TIGRFAMs; TIGR02227; sigpep_I_bact; 1.
DR   PROSITE; PS00501; SPASE_I_1; 1.
DR   PROSITE; PS00760; SPASE_I_2; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protease; Reference proteome.
FT   CHAIN           1..256
FT                   /note="Signal peptidase I"
FT                   /id="PRO_0000109492"
FT   ACT_SITE        32
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        75
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   256 AA;  29676 MW;  C50B0BB11F0EB4DE CRC64;
     MRKQIVELFL IILAVLFIRE YIAQAYTIPS ASMEPTLLVG DFILVNKLVY SLSEPMRGDM
     IVFKYPKNPD IDFIKRIIAR GGDTVEFFPY YDEKNNVLIY KVAVNGKLYE LTYEGEKNYS
     YDCYQYREKL YREDGEVIQH SVCFRNTLLK VPGMVYNAIS SDLCLKYNED GFCVKFVVPE
     GYYFVMGDNR DNSQDSRFWG FVPRENIEGK AFVIYYSGKV PSLTPEEANP LTAVRQIIYA
     LLNPRPSRIG KPLIDK