ID   LEP_CHICK               Reviewed;         163 AA.
AC   O42164;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Leptin;
DE   AltName: Full=Obesity factor;
DE   Flags: Precursor;
GN   Name=LEP; Synonyms=OB;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Broiler; TISSUE=Liver;
RX   PubMed=9524275; DOI=10.1016/s0378-1119(97)00670-7;
RA   Taouis M., Chen J.W., Daviaud C., Dupont J., Derouet M., Simon J.;
RT   "Cloning the chicken leptin gene.";
RL   Gene 208:239-242(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Shaver; TISSUE=Adipose tissue, and Liver;
RA   Ashwell C.M., Czerwinski S.M., McMurtry J.P.;
RT   "Chicken leptin (ob) mRNA, complete cds.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key player in the regulation of energy balance and body
CC       weight control. Once released into the circulation, has central and
CC       peripheral effects by binding LEPR, found in many tissues, which
CC       results in the activation of several major signaling pathways.
CC       {ECO:0000250|UniProtKB:P41159}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Not exclusively localized in adipose tissue but is
CC       also expressed in liver. {ECO:0000269|PubMed:9524275}.
CC   -!- SIMILARITY: Belongs to the leptin family. {ECO:0000305}.
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DR   EMBL; AF012727; AAC60368.1; -; mRNA.
DR   EMBL; AF082500; AAC32380.1; -; mRNA.
DR   AlphaFoldDB; O42164; -.
DR   SMR; O42164; -.
DR   InParanoid; O42164; -.
DR   PhylomeDB; O42164; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
DR   GO; GO:1990051; P:activation of protein kinase C activity; IBA:GO_Central.
DR   GO; GO:0044320; P:cellular response to leptin stimulus; IDA:AgBase.
DR   GO; GO:0006112; P:energy reserve metabolic process; IBA:GO_Central.
DR   GO; GO:0006629; P:lipid metabolic process; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IDA:AgBase.
DR   GO; GO:0032099; P:negative regulation of appetite; IDA:AgBase.
DR   GO; GO:0038108; P:negative regulation of appetite by leptin-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0010629; P:negative regulation of gene expression; IDA:AgBase.
DR   GO; GO:0001552; P:ovarian follicle atresia; IDA:AgBase.
DR   GO; GO:0006909; P:phagocytosis; ISS:UniProtKB.
DR   GO; GO:2000866; P:positive regulation of estradiol secretion; IDA:AgBase.
DR   GO; GO:2000196; P:positive regulation of female gonad development; IDA:AgBase.
DR   GO; GO:0032735; P:positive regulation of interleukin-12 production; ISS:UniProtKB.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; ISS:UniProtKB.
DR   GO; GO:0033686; P:positive regulation of luteinizing hormone secretion; IDA:AgBase.
DR   GO; GO:1900745; P:positive regulation of p38MAPK cascade; IBA:GO_Central.
DR   GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IBA:GO_Central.
DR   GO; GO:2000872; P:positive regulation of progesterone secretion; IDA:AgBase.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; IBA:GO_Central.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
DR   GO; GO:0032868; P:response to insulin; IBA:GO_Central.
DR   GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000065; Leptin.
DR   PANTHER; PTHR11724; PTHR11724; 1.
DR   Pfam; PF02024; Leptin; 1.
DR   PIRSF; PIRSF001837; Leptin; 1.
DR   PRINTS; PR00495; LEPTIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Obesity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..163
FT                   /note="Leptin"
FT                   /id="PRO_0000017692"
FT   DISULFID        113..163
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   163 AA;  18183 MW;  9F578DB2528B18FC CRC64;
     MCWRPLCRLW SYLVYVQAVP CQIFQDDTKT LIKTIVTRIN DISHTSVSAK QRVTGLDFIP
     GLHPILSLSK MDQTLAVYQQ VLTSLPSQNV LQIANDLENL RDLLHLLAFS KSCSLPQTSG
     LQKPESLDGV LEASLYSTEV VALSRLQGSL QDILQQLDIS PEC